Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials
Here we report on the synthesis and characterization of three new N-modified analogues of hemorphin-4 with rhodamine B. Modified with chloroacetyl, chloride cotton fabric has been dyed and color coordinates of the obtained textile materials were determined. Antiviral and virucidal activities of both...
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| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/21/6608 |
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| author | Petar Todorov Stela Georgieva Desislava Staneva Petia Peneva Petar Grozdanov Ivanka Nikolova Ivo Grabchev |
| author_facet | Petar Todorov Stela Georgieva Desislava Staneva Petia Peneva Petar Grozdanov Ivanka Nikolova Ivo Grabchev |
| author_sort | Petar Todorov |
| collection | DOAJ |
| description | Here we report on the synthesis and characterization of three new N-modified analogues of hemorphin-4 with rhodamine B. Modified with chloroacetyl, chloride cotton fabric has been dyed and color coordinates of the obtained textile materials were determined. Antiviral and virucidal activities of both the peptide-rhodamine B compounds and the dyed textile material were studied. Basic physicochemical properties (acid-base behavior, solvent influence, kinetics) related to the elucidation of structural activity of the new modified peptides based on their steric open/closed ring effect were studied. The obtained results lead to the conclusion that in protic solvent with change in pH of the environment, direct control over the dyeing of textiles can be achieved. Both the new hybrid peptide compounds and the modification of functionalized textile materials with these bioactive hemorphins showed virucidal activity against the human respiratory syncytial virus (HRSV-S2) and human adenovirus serotype 5 (HAdV-5) for different time intervals (30 and 60 min) and the most active compound was Rh-3. |
| first_indexed | 2024-03-10T05:56:05Z |
| format | Article |
| id | doaj.art-b05e49090c844688aa44fdee61394903 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T05:56:05Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b05e49090c844688aa44fdee613949032023-11-22T21:23:50ZengMDPI AGMolecules1420-30492021-10-012621660810.3390/molecules26216608Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile MaterialsPetar Todorov0Stela Georgieva1Desislava Staneva2Petia Peneva3Petar Grozdanov4Ivanka Nikolova5Ivo Grabchev6Department of Organic Chemistry, University of Chemical Technology and Metallurgy, 1756 Sofia, BulgariaDepartment of Analytical Chemistry, University of Chemical Technology and Metallurgy, 1756 Sofia, BulgariaDepartment of Textile and Leathers, University of Chemical Technology and Metallurgy, 1756 Sofia, BulgariaDepartment of Organic Chemistry, University of Chemical Technology and Metallurgy, 1756 Sofia, BulgariaThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaFaculty of Medicine, Sofia University “St. Kl. Ohridski”, 1407 Sofia, BulgariaHere we report on the synthesis and characterization of three new N-modified analogues of hemorphin-4 with rhodamine B. Modified with chloroacetyl, chloride cotton fabric has been dyed and color coordinates of the obtained textile materials were determined. Antiviral and virucidal activities of both the peptide-rhodamine B compounds and the dyed textile material were studied. Basic physicochemical properties (acid-base behavior, solvent influence, kinetics) related to the elucidation of structural activity of the new modified peptides based on their steric open/closed ring effect were studied. The obtained results lead to the conclusion that in protic solvent with change in pH of the environment, direct control over the dyeing of textiles can be achieved. Both the new hybrid peptide compounds and the modification of functionalized textile materials with these bioactive hemorphins showed virucidal activity against the human respiratory syncytial virus (HRSV-S2) and human adenovirus serotype 5 (HAdV-5) for different time intervals (30 and 60 min) and the most active compound was Rh-3.https://www.mdpi.com/1420-3049/26/21/6608rhodamine-peptideshemorphinscotton fabricabsorbanceemissionvirucidal effect |
| spellingShingle | Petar Todorov Stela Georgieva Desislava Staneva Petia Peneva Petar Grozdanov Ivanka Nikolova Ivo Grabchev Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials Molecules rhodamine-peptides hemorphins cotton fabric absorbance emission virucidal effect |
| title | Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials |
| title_full | Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials |
| title_fullStr | Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials |
| title_full_unstemmed | Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials |
| title_short | Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials |
| title_sort | synthesis of new modified with rhodamine b peptides for antiviral protection of textile materials |
| topic | rhodamine-peptides hemorphins cotton fabric absorbance emission virucidal effect |
| url | https://www.mdpi.com/1420-3049/26/21/6608 |
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