The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals
<p>Abstract</p> <p>Background</p> <p>The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-09-01
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| Series: | BMC Evolutionary Biology |
| Online Access: | http://www.biomedcentral.com/1471-2148/7/157 |
| _version_ | 1818907412954873856 |
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| author | Dunham Ian Graves Jennifer Hore Timothy Mungall Andrew J Clarke Oliver Rens Willem Edwards Carol A Ferguson-Smith Anne C Ferguson-Smith Malcolm A |
| author_facet | Dunham Ian Graves Jennifer Hore Timothy Mungall Andrew J Clarke Oliver Rens Willem Edwards Carol A Ferguson-Smith Anne C Ferguson-Smith Malcolm A |
| author_sort | Dunham Ian |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation, or that it arose from an ancestrally imprinted chromosome.</p> <p>Results</p> <p>Here we demonstrate that mammalian orthologues of imprinted genes are dispersed amongst autosomes in both monotreme and marsupial karyotypes.</p> <p>Conclusion</p> <p>These data, along with the similar distribution seen in birds, suggest that imprinted genes were not located on an ancestrally imprinted chromosome or associated with a sex chromosome. Our results suggest imprinting evolution was a stepwise, adaptive process, with each gene/cluster independently becoming imprinted as the need arose.</p> |
| first_indexed | 2024-12-19T21:54:43Z |
| format | Article |
| id | doaj.art-b060e8db281e459184651d6a01ae67a5 |
| institution | Directory Open Access Journal |
| issn | 1471-2148 |
| language | English |
| last_indexed | 2024-12-19T21:54:43Z |
| publishDate | 2007-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Evolutionary Biology |
| spelling | doaj.art-b060e8db281e459184651d6a01ae67a52022-12-21T20:04:18ZengBMCBMC Evolutionary Biology1471-21482007-09-017115710.1186/1471-2148-7-157The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammalsDunham IanGraves JenniferHore TimothyMungall Andrew JClarke OliverRens WillemEdwards Carol AFerguson-Smith Anne CFerguson-Smith Malcolm A<p>Abstract</p> <p>Background</p> <p>The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation, or that it arose from an ancestrally imprinted chromosome.</p> <p>Results</p> <p>Here we demonstrate that mammalian orthologues of imprinted genes are dispersed amongst autosomes in both monotreme and marsupial karyotypes.</p> <p>Conclusion</p> <p>These data, along with the similar distribution seen in birds, suggest that imprinted genes were not located on an ancestrally imprinted chromosome or associated with a sex chromosome. Our results suggest imprinting evolution was a stepwise, adaptive process, with each gene/cluster independently becoming imprinted as the need arose.</p>http://www.biomedcentral.com/1471-2148/7/157 |
| spellingShingle | Dunham Ian Graves Jennifer Hore Timothy Mungall Andrew J Clarke Oliver Rens Willem Edwards Carol A Ferguson-Smith Anne C Ferguson-Smith Malcolm A The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals BMC Evolutionary Biology |
| title | The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals |
| title_full | The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals |
| title_fullStr | The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals |
| title_full_unstemmed | The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals |
| title_short | The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals |
| title_sort | evolution of imprinting chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals |
| url | http://www.biomedcentral.com/1471-2148/7/157 |
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