Behavioral Effects of Neural Transplantation
Considerable evidence suggests that transplantation of fetal neural tissue ameliorates the behavioral deficits observed in a variety of animal models of CNS disorders. However, it is also becoming increasingly clear that neural transplants do not necessarily produce behavioral recovery, and in some...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
1992-11-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/096368979200100604 |
| _version_ | 1819108241021337600 |
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| author | Dwaine F. Emerich Michael Ragozzino Michael N. Lehman Paul R. Sanberg |
| author_facet | Dwaine F. Emerich Michael Ragozzino Michael N. Lehman Paul R. Sanberg |
| author_sort | Dwaine F. Emerich |
| collection | DOAJ |
| description | Considerable evidence suggests that transplantation of fetal neural tissue ameliorates the behavioral deficits observed in a variety of animal models of CNS disorders. However, it is also becoming increasingly clear that neural transplants do not necessarily produce behavioral recovery, and in some cases have either no beneficial effects, magnify existing behavioral abnormalities, or even produce a unique constellation of deficits. Regardless, studies demonstrating the successful use of neural transplants in reducing or eliminating behavioral deficits in these animal models has led directly to their clinical application in human neurodegenerative disorders such as Parkinson's disease. This review examines the beneficial and deleterious behavioral consequences of neural transplants in different animal models of human diseases, and discusses the possible mechanisms by which neural transplants might produce behavior recovery. |
| first_indexed | 2024-12-22T03:06:48Z |
| format | Article |
| id | doaj.art-b060fb03194146c1b259a7b814ba77e9 |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-22T03:06:48Z |
| publishDate | 1992-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-b060fb03194146c1b259a7b814ba77e92022-12-21T18:41:03ZengSAGE PublishingCell Transplantation0963-68971555-38921992-11-01110.1177/096368979200100604Behavioral Effects of Neural TransplantationDwaine F. Emerich0Michael Ragozzino1Michael N. Lehman2Paul R. Sanberg3CytoTherapeutics, Inc., Providence, RI, USA 02906Department of Psychology, University of Virginia, Gilmer Hall, Charlottesville, VA 22903, USADepartment of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USADivision of Neurological Surgery, University of South Florida College of Medicine, Tampa, FL 33612, USAConsiderable evidence suggests that transplantation of fetal neural tissue ameliorates the behavioral deficits observed in a variety of animal models of CNS disorders. However, it is also becoming increasingly clear that neural transplants do not necessarily produce behavioral recovery, and in some cases have either no beneficial effects, magnify existing behavioral abnormalities, or even produce a unique constellation of deficits. Regardless, studies demonstrating the successful use of neural transplants in reducing or eliminating behavioral deficits in these animal models has led directly to their clinical application in human neurodegenerative disorders such as Parkinson's disease. This review examines the beneficial and deleterious behavioral consequences of neural transplants in different animal models of human diseases, and discusses the possible mechanisms by which neural transplants might produce behavior recovery.https://doi.org/10.1177/096368979200100604 |
| spellingShingle | Dwaine F. Emerich Michael Ragozzino Michael N. Lehman Paul R. Sanberg Behavioral Effects of Neural Transplantation Cell Transplantation |
| title | Behavioral Effects of Neural Transplantation |
| title_full | Behavioral Effects of Neural Transplantation |
| title_fullStr | Behavioral Effects of Neural Transplantation |
| title_full_unstemmed | Behavioral Effects of Neural Transplantation |
| title_short | Behavioral Effects of Neural Transplantation |
| title_sort | behavioral effects of neural transplantation |
| url | https://doi.org/10.1177/096368979200100604 |
| work_keys_str_mv | AT dwainefemerich behavioraleffectsofneuraltransplantation AT michaelragozzino behavioraleffectsofneuraltransplantation AT michaelnlehman behavioraleffectsofneuraltransplantation AT paulrsanberg behavioraleffectsofneuraltransplantation |