Curcumin-Added Whey Protein Positively Modulates Skeletal Muscle Inflammation and Oxidative Damage after Exhaustive Exercise
(1) Background: Exhaustive exercise can induce muscle damage. The consumption of nutritional compounds with the ability to positively influence the oxidative balance and an exacerbated inflammatory process has been previously studied. However, little is known about the nutritional value of curcumin...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/22/4905 |
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| author | Kelly Aparecida Dias Aline Rosignoli da Conceição Stephanie Michelin Santana Pereira Lívya Alves Oliveira João Vitor da Silva Rodrigues Roberto Sousa Dias Sérgio Oliveira de Paula Antônio José Natali Sérgio Luis Pinto da Matta Reggiani Vilela Gonçalves Elad Tako Hercia Stampini Duarte Martino Ceres Mattos Della Lucia |
| author_facet | Kelly Aparecida Dias Aline Rosignoli da Conceição Stephanie Michelin Santana Pereira Lívya Alves Oliveira João Vitor da Silva Rodrigues Roberto Sousa Dias Sérgio Oliveira de Paula Antônio José Natali Sérgio Luis Pinto da Matta Reggiani Vilela Gonçalves Elad Tako Hercia Stampini Duarte Martino Ceres Mattos Della Lucia |
| author_sort | Kelly Aparecida Dias |
| collection | DOAJ |
| description | (1) Background: Exhaustive exercise can induce muscle damage. The consumption of nutritional compounds with the ability to positively influence the oxidative balance and an exacerbated inflammatory process has been previously studied. However, little is known about the nutritional value of curcumin (CCM) when mixed with whey protein concentrate (WPC). This study was developed to evaluate the effect of CCM-added WPC on inflammatory and oxidative process control and histopathological consequences in muscle tissue submitted to an exhaustive swimming test (ET). (2) Methods: 48 animals were randomly allocated to six groups (<i>n</i> = 8). An ET was performed 4 weeks after the start of the diet and animals were euthanized 24 h post ET. (3) Results: WPC + CCM and CCM groups reduced IL-6 and increased IL-10 expression in muscle tissue. CCM reduced carbonyl protein after ET compared to standard AIN-93M ET and WPC + CCM ET diets. Higher nitric oxide concentrations were observed in animals that consumed WPC + CCM and CCM. Consumption of WPC + CCM or isolated CCM reduced areas of inflammatory infiltrate and fibrotic tissue in the muscle. (4) Conclusions: WPC + CCM and isolated CCM contribute to the reduction in inflammation and oxidative damage caused by the exhaustive swimming test. |
| first_indexed | 2024-03-09T18:05:24Z |
| format | Article |
| id | doaj.art-b061a8ec91974ad0940465ad4fcca966 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T18:05:24Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-b061a8ec91974ad0940465ad4fcca9662023-11-24T09:33:05ZengMDPI AGNutrients2072-66432022-11-011422490510.3390/nu14224905Curcumin-Added Whey Protein Positively Modulates Skeletal Muscle Inflammation and Oxidative Damage after Exhaustive ExerciseKelly Aparecida Dias0Aline Rosignoli da Conceição1Stephanie Michelin Santana Pereira2Lívya Alves Oliveira3João Vitor da Silva Rodrigues4Roberto Sousa Dias5Sérgio Oliveira de Paula6Antônio José Natali7Sérgio Luis Pinto da Matta8Reggiani Vilela Gonçalves9Elad Tako10Hercia Stampini Duarte Martino11Ceres Mattos Della Lucia12Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, BrazilDepartment of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, BrazilDepartment of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, BrazilDepartment of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, BrazilDepartment of General Biology, Universidade Federal de Viçosa, Viçosa 36570-900, MG, BrazilDepartment of General Biology, Universidade Federal de Viçosa, Viçosa 36570-900, MG, BrazilDepartment of General Biology, Universidade Federal de Viçosa, Viçosa 36570-900, MG, BrazilDepartment of Physical Education, Universidade Federal de Viçosa, Viçosa 36570-900, MG, BrazilDepartment of General Biology, Universidade Federal de Viçosa, Viçosa 36570-900, MG, BrazilDepartment of Animal Biology, Universidade Federal de Viçosa, Viçosa 36570-900, MG, BrazilDepartment of Food Science, Cornell University, Stocking Hall, Ithaca, NY 14850, USADepartment of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, BrazilDepartment of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil(1) Background: Exhaustive exercise can induce muscle damage. The consumption of nutritional compounds with the ability to positively influence the oxidative balance and an exacerbated inflammatory process has been previously studied. However, little is known about the nutritional value of curcumin (CCM) when mixed with whey protein concentrate (WPC). This study was developed to evaluate the effect of CCM-added WPC on inflammatory and oxidative process control and histopathological consequences in muscle tissue submitted to an exhaustive swimming test (ET). (2) Methods: 48 animals were randomly allocated to six groups (<i>n</i> = 8). An ET was performed 4 weeks after the start of the diet and animals were euthanized 24 h post ET. (3) Results: WPC + CCM and CCM groups reduced IL-6 and increased IL-10 expression in muscle tissue. CCM reduced carbonyl protein after ET compared to standard AIN-93M ET and WPC + CCM ET diets. Higher nitric oxide concentrations were observed in animals that consumed WPC + CCM and CCM. Consumption of WPC + CCM or isolated CCM reduced areas of inflammatory infiltrate and fibrotic tissue in the muscle. (4) Conclusions: WPC + CCM and isolated CCM contribute to the reduction in inflammation and oxidative damage caused by the exhaustive swimming test.https://www.mdpi.com/2072-6643/14/22/4905exhaustive swimming testcurcumabioactive compoundsantioxidantsinflammatory processoxidative stress |
| spellingShingle | Kelly Aparecida Dias Aline Rosignoli da Conceição Stephanie Michelin Santana Pereira Lívya Alves Oliveira João Vitor da Silva Rodrigues Roberto Sousa Dias Sérgio Oliveira de Paula Antônio José Natali Sérgio Luis Pinto da Matta Reggiani Vilela Gonçalves Elad Tako Hercia Stampini Duarte Martino Ceres Mattos Della Lucia Curcumin-Added Whey Protein Positively Modulates Skeletal Muscle Inflammation and Oxidative Damage after Exhaustive Exercise Nutrients exhaustive swimming test curcuma bioactive compounds antioxidants inflammatory process oxidative stress |
| title | Curcumin-Added Whey Protein Positively Modulates Skeletal Muscle Inflammation and Oxidative Damage after Exhaustive Exercise |
| title_full | Curcumin-Added Whey Protein Positively Modulates Skeletal Muscle Inflammation and Oxidative Damage after Exhaustive Exercise |
| title_fullStr | Curcumin-Added Whey Protein Positively Modulates Skeletal Muscle Inflammation and Oxidative Damage after Exhaustive Exercise |
| title_full_unstemmed | Curcumin-Added Whey Protein Positively Modulates Skeletal Muscle Inflammation and Oxidative Damage after Exhaustive Exercise |
| title_short | Curcumin-Added Whey Protein Positively Modulates Skeletal Muscle Inflammation and Oxidative Damage after Exhaustive Exercise |
| title_sort | curcumin added whey protein positively modulates skeletal muscle inflammation and oxidative damage after exhaustive exercise |
| topic | exhaustive swimming test curcuma bioactive compounds antioxidants inflammatory process oxidative stress |
| url | https://www.mdpi.com/2072-6643/14/22/4905 |
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