Heterologous avian system for quantitative analysis of Syncytin-1 interaction with ASCT2 receptor

Heterologous avian system for quantitative analysis of Syncytin-1 interaction with ASCT2 receptor

Abstract Background Human Syncytin-1 is a placentally-expressed cell surface glycoprotein of retroviral origin. After interaction with ASCT2, its cellular receptor, Syncytin-1 triggers cell–cell fusion and formation of a multinuclear syncytiotrophoblast layer of the placenta. The ASCT2 receptor is a...

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Main Authors: Kryštof Štafl, Martin Trávníček, Dana Kučerová, Ľubomíra Pecnová, Veronika Krchlíková, Eliška Gáliková, Volodymyr Stepanets, Jiří Hejnar, Kateřina Trejbalová
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Retrovirology
Subjects:
Retroviral receptor
Envelope glycoprotein
Envelope-receptor interaction
ASCT2 (SLC1A5)
Syncytin-1
Cell–cell fusion
Online Access:https://doi.org/10.1186/s12977-021-00558-0

Internet

https://doi.org/10.1186/s12977-021-00558-0

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