Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats
<p>Abstract</p> <p>Purpose</p> <p>To determine the effects of 16 wk. of beta-hydroxy-beta-methylbutyrate (HMB) administration on age-related changes in functionality and diffusion tensor imaging (DTI) determined myofiber dimensions.</p> <p>Methods</p>...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2012-04-01
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| Series: | Journal of the International Society of Sports Nutrition |
| Subjects: | |
| Online Access: | http://www.jissn.com/content/9/1/18 |
| _version_ | 1811326902778986496 |
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| author | Wilson Jacob M Grant Samuel C Lee Sang-Rok Masad Ihssan S Park Young-Min Henning Paul C Stout Jeffery R Loenneke Jeremy P Arjmandi Bahram H Panton Lynn B Kim Jeong-Su |
| author_facet | Wilson Jacob M Grant Samuel C Lee Sang-Rok Masad Ihssan S Park Young-Min Henning Paul C Stout Jeffery R Loenneke Jeremy P Arjmandi Bahram H Panton Lynn B Kim Jeong-Su |
| author_sort | Wilson Jacob M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Purpose</p> <p>To determine the effects of 16 wk. of beta-hydroxy-beta-methylbutyrate (HMB) administration on age-related changes in functionality and diffusion tensor imaging (DTI) determined myofiber dimensions.</p> <p>Methods</p> <p>Twelve young (44 wk.), 6 middle-aged (60 wk.), 10 old (86 wk.), and 5 very old (102 wk.) male Fisher-344 rat's body composition and grip strength were assessed at baseline. Following, 6 young, 6 middle-aged, 5 old and 5 very old rats were sacrificed for baseline myofiber dimensions and gene transcript factor expression in the soleus (SOL) and gastrocnemius (GAS). The remaining 6 young and 5 old rats were given HMB for 16 wk. and then sacrificed.</p> <p>Results</p> <p>Fat mass increased in the middle-aged control condition (+49%) but not the middle-aged HMB condition. In addition, fat mass declined (-56%) in the old HMB condition but not the old control condition. Normalized strength declined and maintained respectively in the control and HMB conditions from 44 to 60 wk. and increased (+23%) (p < 0.05) from 86 to 102 wk. in only the HMB condition. Declines occurred in myofiber size in all muscles from 44 to 102 wk. in the control condition(-10 to -15%), but not HMB condition. Atrogin-1 mRNA expression in the SOL and GAS muscles was greater in the 102-wk control condition than all other conditions: SOL (+45%) and GAS (+100%). This elevation was blunted by HMB in the 102 wk. old SOL. There was a condition effect in the SOL for myogenin, which significantly increased (+40%) only in the 102-wk. HMB group relative to the 44-wk. group.</p> <p>Conclusions</p> <p>HMB may blunt age-related losses of strength and myofiber dimensions, possibly through attenuating the rise in protein breakdown.</p> |
| first_indexed | 2024-04-13T14:56:25Z |
| format | Article |
| id | doaj.art-b06212923b82448e8fc21b8959e18bb4 |
| institution | Directory Open Access Journal |
| issn | 1550-2783 |
| language | English |
| last_indexed | 2024-04-13T14:56:25Z |
| publishDate | 2012-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of the International Society of Sports Nutrition |
| spelling | doaj.art-b06212923b82448e8fc21b8959e18bb42022-12-22T02:42:25ZengTaylor & Francis GroupJournal of the International Society of Sports Nutrition1550-27832012-04-01911810.1186/1550-2783-9-18Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in ratsWilson Jacob MGrant Samuel CLee Sang-RokMasad Ihssan SPark Young-MinHenning Paul CStout Jeffery RLoenneke Jeremy PArjmandi Bahram HPanton Lynn BKim Jeong-Su<p>Abstract</p> <p>Purpose</p> <p>To determine the effects of 16 wk. of beta-hydroxy-beta-methylbutyrate (HMB) administration on age-related changes in functionality and diffusion tensor imaging (DTI) determined myofiber dimensions.</p> <p>Methods</p> <p>Twelve young (44 wk.), 6 middle-aged (60 wk.), 10 old (86 wk.), and 5 very old (102 wk.) male Fisher-344 rat's body composition and grip strength were assessed at baseline. Following, 6 young, 6 middle-aged, 5 old and 5 very old rats were sacrificed for baseline myofiber dimensions and gene transcript factor expression in the soleus (SOL) and gastrocnemius (GAS). The remaining 6 young and 5 old rats were given HMB for 16 wk. and then sacrificed.</p> <p>Results</p> <p>Fat mass increased in the middle-aged control condition (+49%) but not the middle-aged HMB condition. In addition, fat mass declined (-56%) in the old HMB condition but not the old control condition. Normalized strength declined and maintained respectively in the control and HMB conditions from 44 to 60 wk. and increased (+23%) (p < 0.05) from 86 to 102 wk. in only the HMB condition. Declines occurred in myofiber size in all muscles from 44 to 102 wk. in the control condition(-10 to -15%), but not HMB condition. Atrogin-1 mRNA expression in the SOL and GAS muscles was greater in the 102-wk control condition than all other conditions: SOL (+45%) and GAS (+100%). This elevation was blunted by HMB in the 102 wk. old SOL. There was a condition effect in the SOL for myogenin, which significantly increased (+40%) only in the 102-wk. HMB group relative to the 44-wk. group.</p> <p>Conclusions</p> <p>HMB may blunt age-related losses of strength and myofiber dimensions, possibly through attenuating the rise in protein breakdown.</p>http://www.jissn.com/content/9/1/18Beta-hydroxy-beta-methylbutyrateAgingFat-free massStrengthSarcopenia |
| spellingShingle | Wilson Jacob M Grant Samuel C Lee Sang-Rok Masad Ihssan S Park Young-Min Henning Paul C Stout Jeffery R Loenneke Jeremy P Arjmandi Bahram H Panton Lynn B Kim Jeong-Su Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats Journal of the International Society of Sports Nutrition Beta-hydroxy-beta-methylbutyrate Aging Fat-free mass Strength Sarcopenia |
| title | Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats |
| title_full | Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats |
| title_fullStr | Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats |
| title_full_unstemmed | Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats |
| title_short | Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats |
| title_sort | beta hydroxy beta methyl butyrate blunts negative age related changes in body composition functionality and myofiber dimensions in rats |
| topic | Beta-hydroxy-beta-methylbutyrate Aging Fat-free mass Strength Sarcopenia |
| url | http://www.jissn.com/content/9/1/18 |
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