HPV vaccination in HIV infection
Persons with HIV are at increased risk of HPV infection, HPV disease, and HPV-related cancers compared to HIV negative persons. In persons with HIV, immune responses to vaccination are often sub-optimal, and while these improve with ART, they often remain lower and decline more rapidly than in HIV-n...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-12-01
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| Series: | Papillomavirus Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405852119300424 |
| _version_ | 1819117029374820352 |
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| author | Charles JN. Lacey |
| author_facet | Charles JN. Lacey |
| author_sort | Charles JN. Lacey |
| collection | DOAJ |
| description | Persons with HIV are at increased risk of HPV infection, HPV disease, and HPV-related cancers compared to HIV negative persons. In persons with HIV, immune responses to vaccination are often sub-optimal, and while these improve with ART, they often remain lower and decline more rapidly than in HIV-negative individuals. Although the evidence base to support the immunogenicity of HPV vaccines in HIV + ve persons is reasonable, the evidence base to support the efficacy of HPV vaccines in HIV + ve individuals is inconsistent. There is one study in HIV + ve men who have sex with men (MSM) which showed no effect, and two other studies, one in HIV + ve women and one in HIV + ve adolescents that showed reduced effectiveness. All these effectiveness studies used Gardasil 4 (G4). Two studies in HIV + ve persons have shown superior immunogenicity of Cervarix (which uses a TLR4 agonist adjuvant) compared to G4. Studies of Hepatitis B vaccines in HIV + ve persons have shown that either (i) increased number of doses (ii) increased vaccine dose, or (iii) TLR agonist adjuvanted vaccines, all produce increased immunogenicity compared to standard vaccine regimes. Therefore, questions remain as to optimal HPV vaccine regimes in HIV and further clinical trials with different HPV vaccine regimes are needed. |
| first_indexed | 2024-12-22T05:26:29Z |
| format | Article |
| id | doaj.art-b062517aeeb348f89960a85758cf70d9 |
| institution | Directory Open Access Journal |
| issn | 2405-8521 |
| language | English |
| last_indexed | 2024-12-22T05:26:29Z |
| publishDate | 2019-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Papillomavirus Research |
| spelling | doaj.art-b062517aeeb348f89960a85758cf70d92022-12-21T18:37:34ZengElsevierPapillomavirus Research2405-85212019-12-018HPV vaccination in HIV infectionCharles JN. Lacey0University of York, UKPersons with HIV are at increased risk of HPV infection, HPV disease, and HPV-related cancers compared to HIV negative persons. In persons with HIV, immune responses to vaccination are often sub-optimal, and while these improve with ART, they often remain lower and decline more rapidly than in HIV-negative individuals. Although the evidence base to support the immunogenicity of HPV vaccines in HIV + ve persons is reasonable, the evidence base to support the efficacy of HPV vaccines in HIV + ve individuals is inconsistent. There is one study in HIV + ve men who have sex with men (MSM) which showed no effect, and two other studies, one in HIV + ve women and one in HIV + ve adolescents that showed reduced effectiveness. All these effectiveness studies used Gardasil 4 (G4). Two studies in HIV + ve persons have shown superior immunogenicity of Cervarix (which uses a TLR4 agonist adjuvant) compared to G4. Studies of Hepatitis B vaccines in HIV + ve persons have shown that either (i) increased number of doses (ii) increased vaccine dose, or (iii) TLR agonist adjuvanted vaccines, all produce increased immunogenicity compared to standard vaccine regimes. Therefore, questions remain as to optimal HPV vaccine regimes in HIV and further clinical trials with different HPV vaccine regimes are needed.http://www.sciencedirect.com/science/article/pii/S2405852119300424 |
| spellingShingle | Charles JN. Lacey HPV vaccination in HIV infection Papillomavirus Research |
| title | HPV vaccination in HIV infection |
| title_full | HPV vaccination in HIV infection |
| title_fullStr | HPV vaccination in HIV infection |
| title_full_unstemmed | HPV vaccination in HIV infection |
| title_short | HPV vaccination in HIV infection |
| title_sort | hpv vaccination in hiv infection |
| url | http://www.sciencedirect.com/science/article/pii/S2405852119300424 |
| work_keys_str_mv | AT charlesjnlacey hpvvaccinationinhivinfection |