Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis

Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis

<p>Abstract</p> <p>Background</p> <p>We have previously demonstrated that immune modulation can be accomplished by administration of gene silenced dendritic cells (DC) using siRNA. In this study, we demonstrate the therapeutic utilization of shRNA-modified DC as an anti...

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Bibliographic Details
Main Authors: Li Rong, Zheng Xiufen, Popov Igor, Zhang Xusheng, Wang Hongmei, Suzuki Motohiko, De Necochea-Campion Rosalia, French Peter W, Chen Di, Siu Leo, Koos David, Inman Robert D, Min Wei-Ping
Format: Article
Language:English
Published: BMC 2012-01-01
Series:Journal of Translational Medicine
Subjects:
shRNA
IL-12
Dendritic cells
Autoimmunity
Collagen-induced arthritis
Online Access:http://www.translational-medicine.com/content/10/1/19

Internet

http://www.translational-medicine.com/content/10/1/19

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