Immune Response of Cattle Infected with African Trypanosomes
Trypanosomosis is the most economically important disease constraint to livestock productivity in sub-Saharan Africa and has significant negative impact in other parts of the world. Livestock are an integral component of farming systems and thus contribute significantly to food and economic security...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
1999-03-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761999000200022 |
| _version_ | 1797756724140048384 |
|---|---|
| author | Katherine A Taylor Bea Mertens |
| author_facet | Katherine A Taylor Bea Mertens |
| author_sort | Katherine A Taylor |
| collection | DOAJ |
| description | Trypanosomosis is the most economically important disease constraint to livestock productivity in sub-Saharan Africa and has significant negative impact in other parts of the world. Livestock are an integral component of farming systems and thus contribute significantly to food and economic security in developing countries. Current methods of control for trypanosomosis are inadequate to prevent the enormous socioeconomic losses resulting from this disease. A vaccine has been viewed as the most desirable control option. However, the complexity of the parasite's antigenic repertoire made development of a vaccine based on the variable surface glycoprotein coat unlikely. As a result, research is now focused on identifying invariant trypanosome components as potential targets for interrupting infection or infection-mediated disease. Immunosuppression appears to be a nearly universal feature of infection with African trypanosomes and thus may represent an essential element of the host-parasite relationship, possibly by reducing the host's ability to mount a protective immune response. Antibody, T cell and macrophage/monocyte responses of infected cattle are depressed in both trypanosusceptible and trypanotolerant breeds of cattle. This review describes the specific T cell and monocyte/macrophage functions that are altered in trypanosome-infected cattle and compares these disorders with those that have been described in the murine model of trypanosomosis. The identification of parasite factors that induce immunosuppression and the mechanisms that mediate depressed immune responses might suggest novel disease intervention strategies. |
| first_indexed | 2024-03-12T18:05:38Z |
| format | Article |
| id | doaj.art-b0667c77d0df44f18d05da61b8ba797d |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:05:38Z |
| publishDate | 1999-03-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-b0667c77d0df44f18d05da61b8ba797d2023-08-02T09:28:33ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601999-03-0194223924410.1590/S0074-02761999000200022Immune Response of Cattle Infected with African TrypanosomesKatherine A TaylorBea MertensTrypanosomosis is the most economically important disease constraint to livestock productivity in sub-Saharan Africa and has significant negative impact in other parts of the world. Livestock are an integral component of farming systems and thus contribute significantly to food and economic security in developing countries. Current methods of control for trypanosomosis are inadequate to prevent the enormous socioeconomic losses resulting from this disease. A vaccine has been viewed as the most desirable control option. However, the complexity of the parasite's antigenic repertoire made development of a vaccine based on the variable surface glycoprotein coat unlikely. As a result, research is now focused on identifying invariant trypanosome components as potential targets for interrupting infection or infection-mediated disease. Immunosuppression appears to be a nearly universal feature of infection with African trypanosomes and thus may represent an essential element of the host-parasite relationship, possibly by reducing the host's ability to mount a protective immune response. Antibody, T cell and macrophage/monocyte responses of infected cattle are depressed in both trypanosusceptible and trypanotolerant breeds of cattle. This review describes the specific T cell and monocyte/macrophage functions that are altered in trypanosome-infected cattle and compares these disorders with those that have been described in the murine model of trypanosomosis. The identification of parasite factors that induce immunosuppression and the mechanisms that mediate depressed immune responses might suggest novel disease intervention strategies.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761999000200022trypanosomosisTrypanosoma congolensebovineimmunodepressionT cellmonocytecytokines |
| spellingShingle | Katherine A Taylor Bea Mertens Immune Response of Cattle Infected with African Trypanosomes Memorias do Instituto Oswaldo Cruz trypanosomosis Trypanosoma congolense bovine immunodepression T cell monocyte cytokines |
| title | Immune Response of Cattle Infected with African Trypanosomes |
| title_full | Immune Response of Cattle Infected with African Trypanosomes |
| title_fullStr | Immune Response of Cattle Infected with African Trypanosomes |
| title_full_unstemmed | Immune Response of Cattle Infected with African Trypanosomes |
| title_short | Immune Response of Cattle Infected with African Trypanosomes |
| title_sort | immune response of cattle infected with african trypanosomes |
| topic | trypanosomosis Trypanosoma congolense bovine immunodepression T cell monocyte cytokines |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761999000200022 |
| work_keys_str_mv | AT katherineataylor immuneresponseofcattleinfectedwithafricantrypanosomes AT beamertens immuneresponseofcattleinfectedwithafricantrypanosomes |