Genomic diversity of the pathogenic fungus Aspergillus fumigatus in Japan reveals the complex genomic basis of azole resistance
Abstract Aspergillus fumigatus is a pathogenic fungus with a global distribution. The emergence of azole-resistant A. fumigatus (ARAf) other than the TR-mutants is a problem in Japan. Additionally, the genetic diversity of A. fumigatus strains in Japan remains relatively unknown. Here we show the di...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-05902-6 |
| _version_ | 1827315852680101888 |
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| author | Xiaohui He Yoko Kusuya Daisuke Hagiwara Takahito Toyotome Teppei Arai Cai Bian Masaki Nagayama Saho Shibata Akira Watanabe Hiroki Takahashi |
| author_facet | Xiaohui He Yoko Kusuya Daisuke Hagiwara Takahito Toyotome Teppei Arai Cai Bian Masaki Nagayama Saho Shibata Akira Watanabe Hiroki Takahashi |
| author_sort | Xiaohui He |
| collection | DOAJ |
| description | Abstract Aspergillus fumigatus is a pathogenic fungus with a global distribution. The emergence of azole-resistant A. fumigatus (ARAf) other than the TR-mutants is a problem in Japan. Additionally, the genetic diversity of A. fumigatus strains in Japan remains relatively unknown. Here we show the diversity in the A. fumigatus strains isolated in Japan as well as the complexity in the global distribution of the pathogenic strains. First, we analyzed the genome sequences of 171 strains from Japan as well as the antifungal susceptibility of these strains. Next, we conducted a population analysis of 876 strains by combining the available genomic data for strains isolated worldwide, which were grouped in six clusters. Finally, a genome-wide association study identified the genomic loci associated with ARAf strains, but not the TR-mutants. These results highlight the complexity of the genomic mechanism underlying the emergence of ARAf strains other than the TR-mutants. |
| first_indexed | 2024-04-24T23:03:59Z |
| format | Article |
| id | doaj.art-b069bbbb575b4ec981e506189bb54995 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-24T23:03:59Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-b069bbbb575b4ec981e506189bb549952024-03-17T12:35:14ZengNature PortfolioCommunications Biology2399-36422024-03-017111010.1038/s42003-024-05902-6Genomic diversity of the pathogenic fungus Aspergillus fumigatus in Japan reveals the complex genomic basis of azole resistanceXiaohui He0Yoko Kusuya1Daisuke Hagiwara2Takahito Toyotome3Teppei Arai4Cai Bian5Masaki Nagayama6Saho Shibata7Akira Watanabe8Hiroki Takahashi9Medical Mycology Research Center, Chiba UniversityBiological Resource Center, National Institute of Technology and EvaluationMedical Mycology Research Center, Chiba UniversityMedical Mycology Research Center, Chiba UniversityMedical Mycology Research Center, Chiba UniversityBGI-ShenzhenGraduate School of Medical and Pharmaceutical Sciences, Chiba UniversityMedical Mycology Research Center, Chiba UniversityMedical Mycology Research Center, Chiba UniversityMedical Mycology Research Center, Chiba UniversityAbstract Aspergillus fumigatus is a pathogenic fungus with a global distribution. The emergence of azole-resistant A. fumigatus (ARAf) other than the TR-mutants is a problem in Japan. Additionally, the genetic diversity of A. fumigatus strains in Japan remains relatively unknown. Here we show the diversity in the A. fumigatus strains isolated in Japan as well as the complexity in the global distribution of the pathogenic strains. First, we analyzed the genome sequences of 171 strains from Japan as well as the antifungal susceptibility of these strains. Next, we conducted a population analysis of 876 strains by combining the available genomic data for strains isolated worldwide, which were grouped in six clusters. Finally, a genome-wide association study identified the genomic loci associated with ARAf strains, but not the TR-mutants. These results highlight the complexity of the genomic mechanism underlying the emergence of ARAf strains other than the TR-mutants.https://doi.org/10.1038/s42003-024-05902-6 |
| spellingShingle | Xiaohui He Yoko Kusuya Daisuke Hagiwara Takahito Toyotome Teppei Arai Cai Bian Masaki Nagayama Saho Shibata Akira Watanabe Hiroki Takahashi Genomic diversity of the pathogenic fungus Aspergillus fumigatus in Japan reveals the complex genomic basis of azole resistance Communications Biology |
| title | Genomic diversity of the pathogenic fungus Aspergillus fumigatus in Japan reveals the complex genomic basis of azole resistance |
| title_full | Genomic diversity of the pathogenic fungus Aspergillus fumigatus in Japan reveals the complex genomic basis of azole resistance |
| title_fullStr | Genomic diversity of the pathogenic fungus Aspergillus fumigatus in Japan reveals the complex genomic basis of azole resistance |
| title_full_unstemmed | Genomic diversity of the pathogenic fungus Aspergillus fumigatus in Japan reveals the complex genomic basis of azole resistance |
| title_short | Genomic diversity of the pathogenic fungus Aspergillus fumigatus in Japan reveals the complex genomic basis of azole resistance |
| title_sort | genomic diversity of the pathogenic fungus aspergillus fumigatus in japan reveals the complex genomic basis of azole resistance |
| url | https://doi.org/10.1038/s42003-024-05902-6 |
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