Cutoff Values of Plasma D-Dimer Level in Patients with Diagnosis of the Venous Thromboembolism after Elective Spinal Surgery
Study DesignA prospective clinical study.PurposeOur objective in the present study was twofold. First, we sought to evaluate the relationship between postoperative venous thromboembolism (VTE) development and concentration of D-dimer to determine the cutoff value in patients who underwent elective s...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Spine Society
2015-04-01
|
| Series: | Asian Spine Journal |
| Subjects: | |
| Online Access: | http://www.asianspinejournal.org/upload/pdf/asj-9-232.pdf |
| _version_ | 1818283086580809728 |
|---|---|
| author | Saeed Hamidi Mahdieh Riazi |
| author_facet | Saeed Hamidi Mahdieh Riazi |
| author_sort | Saeed Hamidi |
| collection | DOAJ |
| description | Study DesignA prospective clinical study.PurposeOur objective in the present study was twofold. First, we sought to evaluate the relationship between postoperative venous thromboembolism (VTE) development and concentration of D-dimer to determine the cutoff value in patients who underwent elective spinal surgery. Second, we identified the predictive risk factors for postoperative VTE.Overview of LiteratureVTE affects the general health of patients and may even cause death. Since the complications of VTE are difficult to predict, the safest and most cost effective diagnostic method should be used in order to confirm a suspected VTE event after spinal surgery.MethodsThis study was performed on 97 patients who underwent elective spinal surgery. The D-dimer assay was carried out on the day before surgery, and on days 1, 3, and 10 following surgery. VTE occurrence and D-dimer levels were compared between the VTE and the control groups.Results Four patients (4.1%) were diagnosed with deep vein thrombosis and one patient (1%) was diagnosed with a pulmonary embolism. The optimum D-dimer cutoff value on day 3 following surgery in the VTE group was determined to be more than 2.1 µg/mL with a sensitivity of 100% and a specificity of 80.7%. Moreover, the duration of postoperative recumbency was a significant risk factor for the development of VTE in this study.ConclusionsWe have demonstrated that postoperative D-dimer measurements in patients who underwent elective spinal surgery can provide a complementary diagnostic screening for VTE during the first week after surgery. |
| first_indexed | 2024-12-13T00:31:19Z |
| format | Article |
| id | doaj.art-b06a283ee54c40a7b724811a3577fc16 |
| institution | Directory Open Access Journal |
| issn | 1976-1902 1976-7846 |
| language | English |
| last_indexed | 2024-12-13T00:31:19Z |
| publishDate | 2015-04-01 |
| publisher | Korean Spine Society |
| record_format | Article |
| series | Asian Spine Journal |
| spelling | doaj.art-b06a283ee54c40a7b724811a3577fc162022-12-22T00:05:19ZengKorean Spine SocietyAsian Spine Journal1976-19021976-78462015-04-019223223810.4184/asj.2015.9.2.232745Cutoff Values of Plasma D-Dimer Level in Patients with Diagnosis of the Venous Thromboembolism after Elective Spinal SurgerySaeed Hamidi0Mahdieh Riazi1Division of Neurosurgery, Department of Surgery, Bou-Ali Medical Educational & Clinical Center, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.Medical Science Research Center, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.Study DesignA prospective clinical study.PurposeOur objective in the present study was twofold. First, we sought to evaluate the relationship between postoperative venous thromboembolism (VTE) development and concentration of D-dimer to determine the cutoff value in patients who underwent elective spinal surgery. Second, we identified the predictive risk factors for postoperative VTE.Overview of LiteratureVTE affects the general health of patients and may even cause death. Since the complications of VTE are difficult to predict, the safest and most cost effective diagnostic method should be used in order to confirm a suspected VTE event after spinal surgery.MethodsThis study was performed on 97 patients who underwent elective spinal surgery. The D-dimer assay was carried out on the day before surgery, and on days 1, 3, and 10 following surgery. VTE occurrence and D-dimer levels were compared between the VTE and the control groups.Results Four patients (4.1%) were diagnosed with deep vein thrombosis and one patient (1%) was diagnosed with a pulmonary embolism. The optimum D-dimer cutoff value on day 3 following surgery in the VTE group was determined to be more than 2.1 µg/mL with a sensitivity of 100% and a specificity of 80.7%. Moreover, the duration of postoperative recumbency was a significant risk factor for the development of VTE in this study.ConclusionsWe have demonstrated that postoperative D-dimer measurements in patients who underwent elective spinal surgery can provide a complementary diagnostic screening for VTE during the first week after surgery.http://www.asianspinejournal.org/upload/pdf/asj-9-232.pdfD-dimerVenous thromboembolismRisk factorsSpineSurgery |
| spellingShingle | Saeed Hamidi Mahdieh Riazi Cutoff Values of Plasma D-Dimer Level in Patients with Diagnosis of the Venous Thromboembolism after Elective Spinal Surgery Asian Spine Journal D-dimer Venous thromboembolism Risk factors Spine Surgery |
| title | Cutoff Values of Plasma D-Dimer Level in Patients with Diagnosis of the Venous Thromboembolism after Elective Spinal Surgery |
| title_full | Cutoff Values of Plasma D-Dimer Level in Patients with Diagnosis of the Venous Thromboembolism after Elective Spinal Surgery |
| title_fullStr | Cutoff Values of Plasma D-Dimer Level in Patients with Diagnosis of the Venous Thromboembolism after Elective Spinal Surgery |
| title_full_unstemmed | Cutoff Values of Plasma D-Dimer Level in Patients with Diagnosis of the Venous Thromboembolism after Elective Spinal Surgery |
| title_short | Cutoff Values of Plasma D-Dimer Level in Patients with Diagnosis of the Venous Thromboembolism after Elective Spinal Surgery |
| title_sort | cutoff values of plasma d dimer level in patients with diagnosis of the venous thromboembolism after elective spinal surgery |
| topic | D-dimer Venous thromboembolism Risk factors Spine Surgery |
| url | http://www.asianspinejournal.org/upload/pdf/asj-9-232.pdf |
| work_keys_str_mv | AT saeedhamidi cutoffvaluesofplasmaddimerlevelinpatientswithdiagnosisofthevenousthromboembolismafterelectivespinalsurgery AT mahdiehriazi cutoffvaluesofplasmaddimerlevelinpatientswithdiagnosisofthevenousthromboembolismafterelectivespinalsurgery |