Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

Astilbin, as a compound of flavonoids, exerts anti-inflammation, antioxidation, and immune-suppression activities. Decreased activation of NF-κB and p38 MAPK and increased activation of SOCS3 and AMPK have been found in astilbin-treated cells. However, what molecules are docked by astilbin to initia...

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Bibliographic Details
Main Authors: Shizhen Ding, Guotao Lu, Biying Wang, Jie Xiang, Chunxia Hu, Zhijie Lin, Yanbing Ding, Weiming Xiao, Weijuan Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
astilbin
ROS
CD4+T cell
cytochrome P450 1B1
anti-inflammation
PPARγ
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.848957/full

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