Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle
Abstract Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia–Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated wi...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2017-07-01
|
Series: | Acta Veterinaria Scandinavica |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13028-017-0318-8 |
_version_ | 1811281855805128704 |
---|---|
author | Suhee Kim Do-Hyeon Yu Jeong-Byoung Chae Kyoung-Seong Choi Hyeon-Cheol Kim Bae-Keun Park Joon-Seok Chae Jinho Park |
author_facet | Suhee Kim Do-Hyeon Yu Jeong-Byoung Chae Kyoung-Seong Choi Hyeon-Cheol Kim Bae-Keun Park Joon-Seok Chae Jinho Park |
author_sort | Suhee Kim |
collection | DOAJ |
description | Abstract Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia–Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis. |
first_indexed | 2024-04-13T01:41:07Z |
format | Article |
id | doaj.art-b06c271daf87490da17767a848aecb27 |
institution | Directory Open Access Journal |
issn | 1751-0147 |
language | English |
last_indexed | 2024-04-13T01:41:07Z |
publishDate | 2017-07-01 |
publisher | BMC |
record_format | Article |
series | Acta Veterinaria Scandinavica |
spelling | doaj.art-b06c271daf87490da17767a848aecb272022-12-22T03:08:11ZengBMCActa Veterinaria Scandinavica1751-01472017-07-015911510.1186/s13028-017-0318-8Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattleSuhee Kim0Do-Hyeon Yu1Jeong-Byoung Chae2Kyoung-Seong Choi3Hyeon-Cheol Kim4Bae-Keun Park5Joon-Seok Chae6Jinho Park7National Institute of Animal Science, Rural Development AdministrationCollege of Veterinary Medicine, Gyeongsang National UniversityLaboratory of Veterinary Internal Medicine, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National UniversityCollege of Ecology and Environmental Science, Kyungpook National UniversityCollege of Veterinary Medicine, Kangwon National UniversityCollege of Veterinary Medicine, Chungnam National UniversityLaboratory of Veterinary Internal Medicine, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National UniversityCollege of Veterinary Medicine, Chonbuk National UniversityAbstract Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia–Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis.http://link.springer.com/article/10.1186/s13028-017-0318-8AnemiaMajor piroplasm surface proteinMPSP type 1Theileria orientalis |
spellingShingle | Suhee Kim Do-Hyeon Yu Jeong-Byoung Chae Kyoung-Seong Choi Hyeon-Cheol Kim Bae-Keun Park Joon-Seok Chae Jinho Park Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle Acta Veterinaria Scandinavica Anemia Major piroplasm surface protein MPSP type 1 Theileria orientalis |
title | Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle |
title_full | Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle |
title_fullStr | Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle |
title_full_unstemmed | Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle |
title_short | Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle |
title_sort | pathogenic genotype of major piroplasm surface protein associated with anemia in theileria orientalis infection in cattle |
topic | Anemia Major piroplasm surface protein MPSP type 1 Theileria orientalis |
url | http://link.springer.com/article/10.1186/s13028-017-0318-8 |
work_keys_str_mv | AT suheekim pathogenicgenotypeofmajorpiroplasmsurfaceproteinassociatedwithanemiaintheileriaorientalisinfectionincattle AT dohyeonyu pathogenicgenotypeofmajorpiroplasmsurfaceproteinassociatedwithanemiaintheileriaorientalisinfectionincattle AT jeongbyoungchae pathogenicgenotypeofmajorpiroplasmsurfaceproteinassociatedwithanemiaintheileriaorientalisinfectionincattle AT kyoungseongchoi pathogenicgenotypeofmajorpiroplasmsurfaceproteinassociatedwithanemiaintheileriaorientalisinfectionincattle AT hyeoncheolkim pathogenicgenotypeofmajorpiroplasmsurfaceproteinassociatedwithanemiaintheileriaorientalisinfectionincattle AT baekeunpark pathogenicgenotypeofmajorpiroplasmsurfaceproteinassociatedwithanemiaintheileriaorientalisinfectionincattle AT joonseokchae pathogenicgenotypeofmajorpiroplasmsurfaceproteinassociatedwithanemiaintheileriaorientalisinfectionincattle AT jinhopark pathogenicgenotypeofmajorpiroplasmsurfaceproteinassociatedwithanemiaintheileriaorientalisinfectionincattle |