Neuroprotective effects of crude extracts, compounds, and isolated molecules obtained from plants in the central nervous system injuries: a systematic review
The number of people with central nervous system (CNS) injuries increases worldwide and only a few therapies are used to mitigate neurological damage. Crude extracts, compounds, and isolated molecules obtained from plants have neuroprotective effects; however, their actions on the central nervous sy...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1249685/full |
| _version_ | 1797688086006595584 |
|---|---|
| author | Maria Vitoria Nava Moura Gabriel Mesquita da Conceição Bahia Marcio Gonçalves Correa Maíza Amanda Araujo Sarges Thaís Alves Lobão Erica Miranda Sanches Karen R. H. Matos Oliveira Anderson Manoel Herculano Carlomagno Pacheco Bahia |
| author_facet | Maria Vitoria Nava Moura Gabriel Mesquita da Conceição Bahia Marcio Gonçalves Correa Maíza Amanda Araujo Sarges Thaís Alves Lobão Erica Miranda Sanches Karen R. H. Matos Oliveira Anderson Manoel Herculano Carlomagno Pacheco Bahia |
| author_sort | Maria Vitoria Nava Moura |
| collection | DOAJ |
| description | The number of people with central nervous system (CNS) injuries increases worldwide and only a few therapies are used to mitigate neurological damage. Crude extracts, compounds, and isolated molecules obtained from plants have neuroprotective effects; however, their actions on the central nervous system are still not fully understood. This systematic review investigated the neuroprotective effects of crude extracts, compound, and isolated molecules obtained from plants in different CNS lesions. This PICO (Population/Problem, Intervention, Control, Outcome) systematic review included in vivo and in vitro studies that used small rodents as experimental models of CNS injuries (P) treated with crude extracts, compounds, and/or isolated molecules obtained from plants (I), compared to non-intervention conditions (C), and that showed a neuroprotective effect (O). Fourteen out of 5,521 studies were selected for qualitative analysis. Several neuroprotective effects (improvement of antioxidant activity, modulation of the inflammatory response, tissue preservation, motor and cognitive recovery) in the brain and spinal cord were reported after treatment with different doses of crude extracts (10 studies), compounds (2 studies), and isolated molecules (2 studies). Crude extracts, compounds, or isolated molecules obtained from plants showed promising neuroprotective effects against several CNS injuries in both the brain and spinal cord, regardless of gender and age, through the modulation of inflammatory activity and oxidative biochemistry, tissue preservation, and recovery of motor and cognitive activity. |
| first_indexed | 2024-03-12T01:26:32Z |
| format | Article |
| id | doaj.art-b06c6ab368e94079a96825b5ad2e3b39 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-12T01:26:32Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-b06c6ab368e94079a96825b5ad2e3b392023-09-12T17:55:57ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-09-011710.3389/fnins.2023.12496851249685Neuroprotective effects of crude extracts, compounds, and isolated molecules obtained from plants in the central nervous system injuries: a systematic reviewMaria Vitoria Nava Moura0Gabriel Mesquita da Conceição Bahia1Marcio Gonçalves Correa2Maíza Amanda Araujo Sarges3Thaís Alves Lobão4Erica Miranda Sanches5Karen R. H. Matos Oliveira6Anderson Manoel Herculano7Carlomagno Pacheco Bahia8Laboratory of Neuroplasticity, Institute of Health Sciences, Federal University of Pará, Belém, BrazilLaboratory of Neuroplasticity, Institute of Health Sciences, Federal University of Pará, Belém, BrazilLaboratory of Neuroplasticity, Institute of Health Sciences, Federal University of Pará, Belém, BrazilLaboratory of Neuroplasticity, Institute of Health Sciences, Federal University of Pará, Belém, BrazilLaboratory of Neuroplasticity, Institute of Health Sciences, Federal University of Pará, Belém, BrazilLaboratory of Neuroplasticity, Institute of Health Sciences, Federal University of Pará, Belém, BrazilLaboratory of Experimental Neuropharmacology, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Experimental Neuropharmacology, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Neuroplasticity, Institute of Health Sciences, Federal University of Pará, Belém, BrazilThe number of people with central nervous system (CNS) injuries increases worldwide and only a few therapies are used to mitigate neurological damage. Crude extracts, compounds, and isolated molecules obtained from plants have neuroprotective effects; however, their actions on the central nervous system are still not fully understood. This systematic review investigated the neuroprotective effects of crude extracts, compound, and isolated molecules obtained from plants in different CNS lesions. This PICO (Population/Problem, Intervention, Control, Outcome) systematic review included in vivo and in vitro studies that used small rodents as experimental models of CNS injuries (P) treated with crude extracts, compounds, and/or isolated molecules obtained from plants (I), compared to non-intervention conditions (C), and that showed a neuroprotective effect (O). Fourteen out of 5,521 studies were selected for qualitative analysis. Several neuroprotective effects (improvement of antioxidant activity, modulation of the inflammatory response, tissue preservation, motor and cognitive recovery) in the brain and spinal cord were reported after treatment with different doses of crude extracts (10 studies), compounds (2 studies), and isolated molecules (2 studies). Crude extracts, compounds, or isolated molecules obtained from plants showed promising neuroprotective effects against several CNS injuries in both the brain and spinal cord, regardless of gender and age, through the modulation of inflammatory activity and oxidative biochemistry, tissue preservation, and recovery of motor and cognitive activity.https://www.frontiersin.org/articles/10.3389/fnins.2023.1249685/fullnatural productsneuroprotectionbrain Injuriescentral nervous systemplants |
| spellingShingle | Maria Vitoria Nava Moura Gabriel Mesquita da Conceição Bahia Marcio Gonçalves Correa Maíza Amanda Araujo Sarges Thaís Alves Lobão Erica Miranda Sanches Karen R. H. Matos Oliveira Anderson Manoel Herculano Carlomagno Pacheco Bahia Neuroprotective effects of crude extracts, compounds, and isolated molecules obtained from plants in the central nervous system injuries: a systematic review Frontiers in Neuroscience natural products neuroprotection brain Injuries central nervous system plants |
| title | Neuroprotective effects of crude extracts, compounds, and isolated molecules obtained from plants in the central nervous system injuries: a systematic review |
| title_full | Neuroprotective effects of crude extracts, compounds, and isolated molecules obtained from plants in the central nervous system injuries: a systematic review |
| title_fullStr | Neuroprotective effects of crude extracts, compounds, and isolated molecules obtained from plants in the central nervous system injuries: a systematic review |
| title_full_unstemmed | Neuroprotective effects of crude extracts, compounds, and isolated molecules obtained from plants in the central nervous system injuries: a systematic review |
| title_short | Neuroprotective effects of crude extracts, compounds, and isolated molecules obtained from plants in the central nervous system injuries: a systematic review |
| title_sort | neuroprotective effects of crude extracts compounds and isolated molecules obtained from plants in the central nervous system injuries a systematic review |
| topic | natural products neuroprotection brain Injuries central nervous system plants |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1249685/full |
| work_keys_str_mv | AT mariavitorianavamoura neuroprotectiveeffectsofcrudeextractscompoundsandisolatedmoleculesobtainedfromplantsinthecentralnervoussysteminjuriesasystematicreview AT gabrielmesquitadaconceicaobahia neuroprotectiveeffectsofcrudeextractscompoundsandisolatedmoleculesobtainedfromplantsinthecentralnervoussysteminjuriesasystematicreview AT marciogoncalvescorrea neuroprotectiveeffectsofcrudeextractscompoundsandisolatedmoleculesobtainedfromplantsinthecentralnervoussysteminjuriesasystematicreview AT maizaamandaaraujosarges neuroprotectiveeffectsofcrudeextractscompoundsandisolatedmoleculesobtainedfromplantsinthecentralnervoussysteminjuriesasystematicreview AT thaisalveslobao neuroprotectiveeffectsofcrudeextractscompoundsandisolatedmoleculesobtainedfromplantsinthecentralnervoussysteminjuriesasystematicreview AT ericamirandasanches neuroprotectiveeffectsofcrudeextractscompoundsandisolatedmoleculesobtainedfromplantsinthecentralnervoussysteminjuriesasystematicreview AT karenrhmatosoliveira neuroprotectiveeffectsofcrudeextractscompoundsandisolatedmoleculesobtainedfromplantsinthecentralnervoussysteminjuriesasystematicreview AT andersonmanoelherculano neuroprotectiveeffectsofcrudeextractscompoundsandisolatedmoleculesobtainedfromplantsinthecentralnervoussysteminjuriesasystematicreview AT carlomagnopachecobahia neuroprotectiveeffectsofcrudeextractscompoundsandisolatedmoleculesobtainedfromplantsinthecentralnervoussysteminjuriesasystematicreview |