The Diagnosis of Multiple Myeloma With Macroglossia and Edema Symptoms
In this case, the importance of multiple myeloma in differential diagnosis of non-specific symptoms, such as macroglossia and significant pretibial edema, is highlighted. A 44-year-old male presented to the internal medicine outpatient clinic with complaints of ongoing and increasing enlargement of...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2017-06-01
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| Series: | Southern Clinics of Istanbul Eurasia |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=KEAH-25993 |
| _version_ | 1797906259377127424 |
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| author | Sonat Pınar Kara Atakan Tekinalp Bülent Bilir Hasan Değirmenci Okan Avcı Meltem Öznur Burhan Turgut |
| author_facet | Sonat Pınar Kara Atakan Tekinalp Bülent Bilir Hasan Değirmenci Okan Avcı Meltem Öznur Burhan Turgut |
| author_sort | Sonat Pınar Kara |
| collection | DOAJ |
| description | In this case, the importance of multiple myeloma in differential diagnosis of non-specific symptoms, such as macroglossia and significant pretibial edema, is highlighted. A 44-year-old male presented to the internal medicine outpatient clinic with complaints of ongoing and increasing enlargement of the tongue, difficulty in swallowing, and swelling of legs, all of which had been occurring for 6 months. In the CT scan, significant symmetrical enlargement of the tongue was detected. Making a pre-diagnosis of amyloidosis, a biopsy of the tongue was performed, but the results did not suggest amyloidosis. A rectal biopsy was therefore subsequently performed, and this time the results showed amyloid accumulation. Findings from the transthoracic echocardiography showed an ejection fraction of 48%, contrast hypertrophy in the left ventricle, Grade 3 diastolic dysfunction, 15–19 ml of pericardial fluid around the heart, and mild mitral failure. Taking into consideration the pathological and cardiologic findings, the patient was diagnosed with amyloidosis. Bearing in mind the possible relation between primary hematologic malignancy and amyloidosis, a bone marrow aspiration and a bone marrow biopsy were performed. From the results of the biopsy and aspiration of bone marrow, the patient was diagnosed with multiple myeloma and treatment plans were made accordingly. However, as the patient was in the process of undergoing treatment he died due to the development of cardiopulmonary failure. |
| first_indexed | 2024-04-10T10:19:13Z |
| format | Article |
| id | doaj.art-b06dea8653cb4bf6b445920ab435ba2f |
| institution | Directory Open Access Journal |
| issn | 2587-0998 |
| language | English |
| last_indexed | 2024-04-10T10:19:13Z |
| publishDate | 2017-06-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Southern Clinics of Istanbul Eurasia |
| spelling | doaj.art-b06dea8653cb4bf6b445920ab435ba2f2023-02-15T16:21:45ZengKARE PublishingSouthern Clinics of Istanbul Eurasia2587-09982017-06-01281535610.14744/scie.2016.25993KEAH-25993The Diagnosis of Multiple Myeloma With Macroglossia and Edema SymptomsSonat Pınar Kara0Atakan Tekinalp1Bülent Bilir2Hasan Değirmenci3Okan Avcı4Meltem Öznur5Burhan Turgut6Department of Internal Medicine, Namık Kemal University Faculty of Medicine, Tekirdağ, TurkeyDepartment of Hematology, Namık Kemal University Faculty of Medicine, Tekirdağ, TurkeyDepartment of Internal Medicine, Namık Kemal University Faculty of Medicine, Tekirdağ, TurkeyDepartment of Cardiology, Namık Kemal University Faculty of Medicine, Tekirdağ, TurkeyDepartment of Internal Medicine, Namık Kemal University Faculty of Medicine, Tekirdağ, TurkeyDepartment of Pathology, Namık Kemal University Faculty of Medicine, Tekirdağ, TurkeyDepartment of Hematology, Namık Kemal University Faculty of Medicine, Tekirdağ, TurkeyIn this case, the importance of multiple myeloma in differential diagnosis of non-specific symptoms, such as macroglossia and significant pretibial edema, is highlighted. A 44-year-old male presented to the internal medicine outpatient clinic with complaints of ongoing and increasing enlargement of the tongue, difficulty in swallowing, and swelling of legs, all of which had been occurring for 6 months. In the CT scan, significant symmetrical enlargement of the tongue was detected. Making a pre-diagnosis of amyloidosis, a biopsy of the tongue was performed, but the results did not suggest amyloidosis. A rectal biopsy was therefore subsequently performed, and this time the results showed amyloid accumulation. Findings from the transthoracic echocardiography showed an ejection fraction of 48%, contrast hypertrophy in the left ventricle, Grade 3 diastolic dysfunction, 15–19 ml of pericardial fluid around the heart, and mild mitral failure. Taking into consideration the pathological and cardiologic findings, the patient was diagnosed with amyloidosis. Bearing in mind the possible relation between primary hematologic malignancy and amyloidosis, a bone marrow aspiration and a bone marrow biopsy were performed. From the results of the biopsy and aspiration of bone marrow, the patient was diagnosed with multiple myeloma and treatment plans were made accordingly. However, as the patient was in the process of undergoing treatment he died due to the development of cardiopulmonary failure.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=KEAH-25993edemaheart failuremacroglossiamultiple myeloma. |
| spellingShingle | Sonat Pınar Kara Atakan Tekinalp Bülent Bilir Hasan Değirmenci Okan Avcı Meltem Öznur Burhan Turgut The Diagnosis of Multiple Myeloma With Macroglossia and Edema Symptoms Southern Clinics of Istanbul Eurasia edema heart failure macroglossia multiple myeloma. |
| title | The Diagnosis of Multiple Myeloma With Macroglossia and Edema Symptoms |
| title_full | The Diagnosis of Multiple Myeloma With Macroglossia and Edema Symptoms |
| title_fullStr | The Diagnosis of Multiple Myeloma With Macroglossia and Edema Symptoms |
| title_full_unstemmed | The Diagnosis of Multiple Myeloma With Macroglossia and Edema Symptoms |
| title_short | The Diagnosis of Multiple Myeloma With Macroglossia and Edema Symptoms |
| title_sort | diagnosis of multiple myeloma with macroglossia and edema symptoms |
| topic | edema heart failure macroglossia multiple myeloma. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=KEAH-25993 |
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