Impact of beta-tricalcium phosphate on preventing tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaw in rats
Abstract Antiresorptive or antiangiogenic drugs can cause medication-related osteonecrosis of the jaw that is refractory. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) may be caused by procedures such as tooth extraction damage the alveolar bone, release bisphosphonates (BPs) and impede he...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-43315-3 |
| _version_ | 1797452934313672704 |
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| author | Naoki Funayama Takahiro Yagyuu Mitsuhiko Imada Yoshihiro Ueyama Yosuke Nakagawa Tadaaki Kirita |
| author_facet | Naoki Funayama Takahiro Yagyuu Mitsuhiko Imada Yoshihiro Ueyama Yosuke Nakagawa Tadaaki Kirita |
| author_sort | Naoki Funayama |
| collection | DOAJ |
| description | Abstract Antiresorptive or antiangiogenic drugs can cause medication-related osteonecrosis of the jaw that is refractory. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) may be caused by procedures such as tooth extraction damage the alveolar bone, release bisphosphonates (BPs) and impede healing. This study investigated strategies for BRONJ prevention and molecular mechanisms of its onset. We assessed the effectiveness of filling extraction sockets with beta-tricalcium phosphate (β-TCP). Rats were administered zoledronic acid (ZA) 1.2 mg/kg once per week for 2 weeks, and a molar was extracted. They were randomly assigned to the β-TCP group (bone defects filled with 0.01 g of β-TCP) or control group. Tissue content measurements indicated 2.2 ng of ZA per socket in the β-TCP group and 4.9 ng in the control group, confirming BP distribution and BP adsorption by β-TCP in vivo. At 4 weeks after extraction, the β-TCP group had normal mucosal coverage without inflammation. Moreover, at 8 weeks after extraction, enhanced bone healing, socket coverage, and new bone formation were observed in the β-TCP group. Connective tissue in the extraction sockets suggested that local increases in BP concentrations may suppress the local autophagy mechanisms involved in BRONJ. Filling extraction sockets with β-TCP may prevent BRONJ. |
| first_indexed | 2024-03-09T15:15:51Z |
| format | Article |
| id | doaj.art-b06f36c0a4fd40d287aa67f1d382831b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:15:51Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b06f36c0a4fd40d287aa67f1d382831b2023-11-26T13:07:37ZengNature PortfolioScientific Reports2045-23222023-09-0113111110.1038/s41598-023-43315-3Impact of beta-tricalcium phosphate on preventing tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaw in ratsNaoki Funayama0Takahiro Yagyuu1Mitsuhiko Imada2Yoshihiro Ueyama3Yosuke Nakagawa4Tadaaki Kirita5Department of Oral and Maxillofacial Surgery, Nara Medical UniversityDepartment of Oral and Maxillofacial Surgery, Nara Medical UniversityDepartment of Oral and Maxillofacial Surgery, Nara Medical UniversityDepartment of Oral and Maxillofacial Surgery, Nara Medical UniversityDepartment of Oral and Maxillofacial Surgery, Nara Medical UniversityDepartment of Oral and Maxillofacial Surgery, Nara Medical UniversityAbstract Antiresorptive or antiangiogenic drugs can cause medication-related osteonecrosis of the jaw that is refractory. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) may be caused by procedures such as tooth extraction damage the alveolar bone, release bisphosphonates (BPs) and impede healing. This study investigated strategies for BRONJ prevention and molecular mechanisms of its onset. We assessed the effectiveness of filling extraction sockets with beta-tricalcium phosphate (β-TCP). Rats were administered zoledronic acid (ZA) 1.2 mg/kg once per week for 2 weeks, and a molar was extracted. They were randomly assigned to the β-TCP group (bone defects filled with 0.01 g of β-TCP) or control group. Tissue content measurements indicated 2.2 ng of ZA per socket in the β-TCP group and 4.9 ng in the control group, confirming BP distribution and BP adsorption by β-TCP in vivo. At 4 weeks after extraction, the β-TCP group had normal mucosal coverage without inflammation. Moreover, at 8 weeks after extraction, enhanced bone healing, socket coverage, and new bone formation were observed in the β-TCP group. Connective tissue in the extraction sockets suggested that local increases in BP concentrations may suppress the local autophagy mechanisms involved in BRONJ. Filling extraction sockets with β-TCP may prevent BRONJ.https://doi.org/10.1038/s41598-023-43315-3 |
| spellingShingle | Naoki Funayama Takahiro Yagyuu Mitsuhiko Imada Yoshihiro Ueyama Yosuke Nakagawa Tadaaki Kirita Impact of beta-tricalcium phosphate on preventing tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaw in rats Scientific Reports |
| title | Impact of beta-tricalcium phosphate on preventing tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaw in rats |
| title_full | Impact of beta-tricalcium phosphate on preventing tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaw in rats |
| title_fullStr | Impact of beta-tricalcium phosphate on preventing tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaw in rats |
| title_full_unstemmed | Impact of beta-tricalcium phosphate on preventing tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaw in rats |
| title_short | Impact of beta-tricalcium phosphate on preventing tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaw in rats |
| title_sort | impact of beta tricalcium phosphate on preventing tooth extraction triggered bisphosphonate related osteonecrosis of the jaw in rats |
| url | https://doi.org/10.1038/s41598-023-43315-3 |
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