Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance

Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance

Nucleoside reverse transcriptase inhibitors (NRTIs) were the first drugs used to treat human immunodeficiency virus (HIV) the cause of acquired immunodeficiency syndrome. Development of severe mitochondrial toxicity has been well documented in patients infected with HIV and administered NRTIs. In vi...

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Bibliographic Details
Main Author:	Matthew J. Young
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-11-01
Series:	Frontiers in Molecular Biosciences
Subjects:	nucleoside reverse transcriptase inhibitors mitochondrial DNA polymerase gamma human immunodeficiency virus (HIV) mitochondrial diseases cancer antiviral ribonucleosides
Online Access:	http://journal.frontiersin.org/article/10.3389/fmolb.2017.00074/full

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