Functionalized Anatomical Models for Computational Life Sciences
The advent of detailed computational anatomical models has opened new avenues for computational life sciences (CLS). To date, static models representing the anatomical environment have been used in many applications but are insufficient when the dynamics of the body prevents separation of anatomical...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.01594/full |
| _version_ | 1811325490827362304 |
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| author | Esra Neufeld Bryn Lloyd Beatrice Schneider Wolfgang Kainz Niels Kuster Niels Kuster |
| author_facet | Esra Neufeld Bryn Lloyd Beatrice Schneider Wolfgang Kainz Niels Kuster Niels Kuster |
| author_sort | Esra Neufeld |
| collection | DOAJ |
| description | The advent of detailed computational anatomical models has opened new avenues for computational life sciences (CLS). To date, static models representing the anatomical environment have been used in many applications but are insufficient when the dynamics of the body prevents separation of anatomical geometrical variability from physics and physiology. Obvious examples include the assessment of thermal risks in magnetic resonance imaging and planning for radiofrequency and acoustic cancer treatment, where posture and physiology-related changes in shape (e.g., breathing) or tissue behavior (e.g., thermoregulation) affect the impact. Advanced functionalized anatomical models can overcome these limitations and dramatically broaden the applicability of CLS in basic research, the development of novel devices/therapies, and the assessment of their safety and efficacy. Various forms of functionalization are discussed in this paper: (i) shape parametrization (e.g., heartbeat, population variability), (ii) physical property distributions (e.g., image-based inhomogeneity), (iii) physiological dynamics (e.g., tissue and organ behavior), and (iv) integration of simulation/measurement data (e.g., exposure conditions, “validation evidence” supporting model tuning and validation). Although current model functionalization may only represent a small part of the physiology, it already facilitates the next level of realism by (i) driving consistency among anatomy and different functionalization layers and highlighting dependencies, (ii) enabling third-party use of validated functionalization layers as established simulation tools, and (iii) therefore facilitating their application as building blocks in network or multi-scale computational models. Integration in functionalized anatomical models thus leverages and potentiates the value of sub-models and simulation/measurement data toward ever-increasing simulation realism. In our o2S2PARC platform, we propose to expand the concept of functionalized anatomical models to establish an integration and sharing service for heterogeneous computational models, ranging from the molecular to the organ level. The objective of o2S2PARC is to integrate all models developed within the National Institutes of Health SPARC initiative in a unified anatomical and computational environment, to study the role of the peripheral nervous system in controlling organ physiology. The functionalization concept, as outlined for the o2S2PARC platform, could form the basis for many other application areas of CLS. The relationship to other ongoing initiatives, such as the Physiome Project, is also presented. |
| first_indexed | 2024-04-13T14:34:06Z |
| format | Article |
| id | doaj.art-b07201ba9fd340d9bd71d6885882bc1a |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-13T14:34:06Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-b07201ba9fd340d9bd71d6885882bc1a2022-12-22T02:43:06ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-11-01910.3389/fphys.2018.01594385070Functionalized Anatomical Models for Computational Life SciencesEsra Neufeld0Bryn Lloyd1Beatrice Schneider2Wolfgang Kainz3Niels Kuster4Niels Kuster5IT'IS Foundation for Research on Information Technologies in Society, Zurich, SwitzerlandIT'IS Foundation for Research on Information Technologies in Society, Zurich, SwitzerlandÄrzteteam 51, Arbeitsmedizin Brugg, Brugg, SwitzerlandDivision of Biomedical Physics, OSEL, CDRH, Food and Drug Administration, Silver Spring, MD, United StatesIT'IS Foundation for Research on Information Technologies in Society, Zurich, SwitzerlandSwiss Federal Institute of Technology (ETHZ), Zurich, SwitzerlandThe advent of detailed computational anatomical models has opened new avenues for computational life sciences (CLS). To date, static models representing the anatomical environment have been used in many applications but are insufficient when the dynamics of the body prevents separation of anatomical geometrical variability from physics and physiology. Obvious examples include the assessment of thermal risks in magnetic resonance imaging and planning for radiofrequency and acoustic cancer treatment, where posture and physiology-related changes in shape (e.g., breathing) or tissue behavior (e.g., thermoregulation) affect the impact. Advanced functionalized anatomical models can overcome these limitations and dramatically broaden the applicability of CLS in basic research, the development of novel devices/therapies, and the assessment of their safety and efficacy. Various forms of functionalization are discussed in this paper: (i) shape parametrization (e.g., heartbeat, population variability), (ii) physical property distributions (e.g., image-based inhomogeneity), (iii) physiological dynamics (e.g., tissue and organ behavior), and (iv) integration of simulation/measurement data (e.g., exposure conditions, “validation evidence” supporting model tuning and validation). Although current model functionalization may only represent a small part of the physiology, it already facilitates the next level of realism by (i) driving consistency among anatomy and different functionalization layers and highlighting dependencies, (ii) enabling third-party use of validated functionalization layers as established simulation tools, and (iii) therefore facilitating their application as building blocks in network or multi-scale computational models. Integration in functionalized anatomical models thus leverages and potentiates the value of sub-models and simulation/measurement data toward ever-increasing simulation realism. In our o2S2PARC platform, we propose to expand the concept of functionalized anatomical models to establish an integration and sharing service for heterogeneous computational models, ranging from the molecular to the organ level. The objective of o2S2PARC is to integrate all models developed within the National Institutes of Health SPARC initiative in a unified anatomical and computational environment, to study the role of the peripheral nervous system in controlling organ physiology. The functionalization concept, as outlined for the o2S2PARC platform, could form the basis for many other application areas of CLS. The relationship to other ongoing initiatives, such as the Physiome Project, is also presented.https://www.frontiersin.org/article/10.3389/fphys.2018.01594/fullcomputational life sciencescomputational phantomanatomical modelfunctionalizationsimulationmodeling |
| spellingShingle | Esra Neufeld Bryn Lloyd Beatrice Schneider Wolfgang Kainz Niels Kuster Niels Kuster Functionalized Anatomical Models for Computational Life Sciences Frontiers in Physiology computational life sciences computational phantom anatomical model functionalization simulation modeling |
| title | Functionalized Anatomical Models for Computational Life Sciences |
| title_full | Functionalized Anatomical Models for Computational Life Sciences |
| title_fullStr | Functionalized Anatomical Models for Computational Life Sciences |
| title_full_unstemmed | Functionalized Anatomical Models for Computational Life Sciences |
| title_short | Functionalized Anatomical Models for Computational Life Sciences |
| title_sort | functionalized anatomical models for computational life sciences |
| topic | computational life sciences computational phantom anatomical model functionalization simulation modeling |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.01594/full |
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