High density lipoprotein-3 in diabetic retinopathy patients: relationship to total antioxidant capacity and nitric oxide level
AIM: To examine the association between high density lipoprotein(HDL)3 cholesterol, nitrite plus nitrate(NOx)and total antioxidant status in diabetic retinopathy patients compared to controls.<p>METHODS: This was a prospective, case-control study. One hundred and six participants were subdivid...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2017-12-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2017/12/201712003.pdf |
| Summary: | AIM: To examine the association between high density lipoprotein(HDL)3 cholesterol, nitrite plus nitrate(NOx)and total antioxidant status in diabetic retinopathy patients compared to controls.<p>METHODS: This was a prospective, case-control study. One hundred and six participants were subdivided into three groups. Eighty-four type 2 diabetes patients with and without retinopathy and 22 healthy controls were included in this study. Serum HDL<sub>3</sub> concentrations were assayed and serum NOx levels were determined in all patients. Total antioxidant capacity was measured using the ferric reducing power of plasma(FRAP)assay.<p>RESULTS: Among the subjects with diabetes mellitus(DM), fasting glucose, HbA1c and triglycerides were significantly higher than the healthy controls. HDL<sub>3</sub> level was 14.4(12.0)mg/dl in healthy subjects, 18.1(12.6)mg/dl in the diabetic retinopathy group and 14.0(12.5)mg/dl in diabetic patients without retinopathy, and was statistically similar between the groups(<i>P</i>=0.262). HDL level was similar between groups in our population. FRAP level was lower in patients with DM compared to healthy controls(<i>P</i>=0.003), but was not different between the DR and the non-DR groups(<i>P</i>=0.913).<p>CONCLUSION: In our study, we demonstrated that HDL and HDL<sub>3</sub> subgroup levels didn't significantly differ between DM2 patients with DR and without DR and healthy controls. Determination of HDL<sub>3</sub> cholesterol, in addition to total HDL cholesterol, may not predict the actual risk for diabetic retinopathy. Serum NOx was observed to be higher in diabetic participants and FRAP level was low. |
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| ISSN: | 1672-5123 1672-5123 |