Ferroptosis in pulmonary fibrosis: an emerging therapeutic target
In recent years, the role of ferroptosis in pulmonary fibrosis has garnered increasing interest as a potential therapeutic target. Pulmonary fibrosis is a pathological process characterized by the accumulation of extracellular matrix in affected lung tissues, and currently, there are no effective th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1205771/full |
| _version_ | 1797741428475953152 |
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| author | Chunyan Wang Shucheng Hua Lei Song |
| author_facet | Chunyan Wang Shucheng Hua Lei Song |
| author_sort | Chunyan Wang |
| collection | DOAJ |
| description | In recent years, the role of ferroptosis in pulmonary fibrosis has garnered increasing interest as a potential therapeutic target. Pulmonary fibrosis is a pathological process characterized by the accumulation of extracellular matrix in affected lung tissues, and currently, there are no effective therapies for preventing or reversing the fibrotic lesions. Ferroptosis is a form of programmed cell death that is regulated by a network of enzymes and signaling pathways. Dysregulation of ferroptosis has been implicated in several diseases, including pulmonary fibrosis. The accumulation of lipid peroxides in the course of ferroptosis causes damage to cell membranes and other cellular components, leading ultimately to cell death. Relevant targets for therapeutic intervention in ferroptosis include key enzymes, such as glutathione peroxidase 4, transcription factors like nuclear factor erythroid 2-related factor 2, and iron chelation. This review provides an overview of the emerging role of ferroptosis in pulmonary fibrosis and highlights potential therapeutic targets in this pathway. Further research is needed to develop safe and effective approaches targeting ferroptosis in treatment of pulmonary fibrosis. |
| first_indexed | 2024-03-12T14:26:34Z |
| format | Article |
| id | doaj.art-b077df115c76459e8a5e153933614b5d |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-12T14:26:34Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-b077df115c76459e8a5e153933614b5d2023-08-18T05:40:31ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-08-011410.3389/fphys.2023.12057711205771Ferroptosis in pulmonary fibrosis: an emerging therapeutic targetChunyan Wang0Shucheng Hua1Lei Song2Department of General Practice, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, ChinaDepartment of Respiratory Medicine, Center for Pathogen Biology and Infectious Diseases, The First Hospital of Jilin University, Changchun, ChinaDepartment of Respiratory Medicine, Center for Pathogen Biology and Infectious Diseases, The First Hospital of Jilin University, Changchun, ChinaIn recent years, the role of ferroptosis in pulmonary fibrosis has garnered increasing interest as a potential therapeutic target. Pulmonary fibrosis is a pathological process characterized by the accumulation of extracellular matrix in affected lung tissues, and currently, there are no effective therapies for preventing or reversing the fibrotic lesions. Ferroptosis is a form of programmed cell death that is regulated by a network of enzymes and signaling pathways. Dysregulation of ferroptosis has been implicated in several diseases, including pulmonary fibrosis. The accumulation of lipid peroxides in the course of ferroptosis causes damage to cell membranes and other cellular components, leading ultimately to cell death. Relevant targets for therapeutic intervention in ferroptosis include key enzymes, such as glutathione peroxidase 4, transcription factors like nuclear factor erythroid 2-related factor 2, and iron chelation. This review provides an overview of the emerging role of ferroptosis in pulmonary fibrosis and highlights potential therapeutic targets in this pathway. Further research is needed to develop safe and effective approaches targeting ferroptosis in treatment of pulmonary fibrosis.https://www.frontiersin.org/articles/10.3389/fphys.2023.1205771/fullGPx4natural compoundsp53lipid peroxidesNrf2 |
| spellingShingle | Chunyan Wang Shucheng Hua Lei Song Ferroptosis in pulmonary fibrosis: an emerging therapeutic target Frontiers in Physiology GPx4 natural compounds p53 lipid peroxides Nrf2 |
| title | Ferroptosis in pulmonary fibrosis: an emerging therapeutic target |
| title_full | Ferroptosis in pulmonary fibrosis: an emerging therapeutic target |
| title_fullStr | Ferroptosis in pulmonary fibrosis: an emerging therapeutic target |
| title_full_unstemmed | Ferroptosis in pulmonary fibrosis: an emerging therapeutic target |
| title_short | Ferroptosis in pulmonary fibrosis: an emerging therapeutic target |
| title_sort | ferroptosis in pulmonary fibrosis an emerging therapeutic target |
| topic | GPx4 natural compounds p53 lipid peroxides Nrf2 |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1205771/full |
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