Correlation of serum concentration cyclin-dependent kinase 4 and cyclin-dependent kinase 6 with breast cancer in Babylon province
Objectives: The goal of this study to estimate the correlation between breast cancer and cyclin-dependent kinase 4 (CDK4)\CDK6 enzyme concentrations in the occurrence of breast cancer and breast cancer subtypes. Methods: A total of 80 breast cancer patients are subdivided according to molecular clas...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Medical Journal of Babylon |
| Subjects: | |
| Online Access: | http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2020;volume=17;issue=2;spage=199;epage=203;aulast=Al-Owaidi |
| Summary: | Objectives: The goal of this study to estimate the correlation between breast cancer and cyclin-dependent kinase 4 (CDK4)\CDK6 enzyme concentrations in the occurrence of breast cancer and breast cancer subtypes. Methods: A total of 80 breast cancer patients are subdivided according to molecular classification into four groups, Luminal A, Luminal B, Her2/neu enriched, and TPN and 80 healthy individuals as control were enrolled; biochemical tests and body mass index were assayed. Results: No significant differences were found between patients and control groups and no significant differences were found among breast cancer subtypes in the concentrations of CDK4 (P > 0.05). There were no significant differences found between patients and control groups and no significant difference in the CDK6 concentration among subtypes groups (P > 0.05). The correlation between age, CDK4, and CDK6 in cases and control revealed that the correlation was absent between age, CDK4, and CDK6 concentration, except a weak positive correlation was found between CDK4 and CDK6 concentrations. Conclusion: There was no significant difference in serum levels of CDK4 and serum level of CDK6 between case and control and among patient subtypes. |
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| ISSN: | 1812-156X 2312-6760 |