Biannual Administrations of Azithromycin and the Gastrointestinal Microbiome of Malawian Children: A Nested Cohort Study Within a Randomized Controlled Trial

Biannual Administrations of Azithromycin and the Gastrointestinal Microbiome of Malawian Children: A Nested Cohort Study Within a Randomized Controlled Trial

Community-level mass treatment with azithromycin has been associated with a mortality benefit in children. However, antibiotic exposures result in disruption of the gut microbiota and repeated exposures may reduce recovery of the gut flora. We conducted a nested cohort study within the framework of...

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Bibliographic Details
Main Authors: David Chaima, Harry Pickering, John D. Hart, Sarah E. Burr, Joanna Houghton, Kenneth Maleta, Khumbo Kalua, Robin L. Bailey, Martin J. Holland
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Public Health
Subjects:
mass drug administration
azithromycin
gut microbiota
V4-16S rRNA sequencing
amplicon
Online Access:https://www.frontiersin.org/articles/10.3389/fpubh.2022.756318/full

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