Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management
Behçet’s disease is a systemic vasculitis that affects multiple organs. The most common manifestations are oral and genital ulcerations and recurrent uveitis. Uveitis can be an initial symptom in 10–20% of cases and leads to blindness in 16–25% of patients. The management of this disease is evolving...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/21/5174 |
| _version_ | 1797512237382893568 |
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| author | Hanna Zając Anna Turno-Kręcicka |
| author_facet | Hanna Zając Anna Turno-Kręcicka |
| author_sort | Hanna Zając |
| collection | DOAJ |
| description | Behçet’s disease is a systemic vasculitis that affects multiple organs. The most common manifestations are oral and genital ulcerations and recurrent uveitis. Uveitis can be an initial symptom in 10–20% of cases and leads to blindness in 16–25% of patients. The management of this disease is evolving due to the clinical phenotypes recently described in the literature and increasing focus on the detection of subclinical inflammation to enable correct therapeutic decisions. The first line treatment is azathioprine, followed by various immunosuppressive and biological agents as alternatives in severe or refractory cases. This review summarizes scientific articles about the etiology of, diagnostic tools for and treatment of the ocular manifestations of Behçet’s disease available in the PubMed database from 1 January 2016 to 1 May 2021. A multidisciplinary approach is necessary to effectively prevent permanent damage and thus improve the life quality of the patients. Therefore, it is crucial to raise awareness of the common clusters of symptoms, use of modern imaging methods, such as ocular computed tomography and fluorescein angiography, and novelty treatment algorithms to enable early diagnosis and appropriate management. |
| first_indexed | 2024-03-10T05:59:00Z |
| format | Article |
| id | doaj.art-b0798c040b5b45b29cafcb5f28bb8518 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T05:59:00Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b0798c040b5b45b29cafcb5f28bb85182023-11-22T21:08:26ZengMDPI AGJournal of Clinical Medicine2077-03832021-11-011021517410.3390/jcm10215174Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease ManagementHanna Zając0Anna Turno-Kręcicka1Department of Ophthalmology, University Clinical Hospital in Wroclaw, 50-556 Wroclaw, PolandDepartment of Ophthalmology, University Clinical Hospital in Wroclaw, 50-556 Wroclaw, PolandBehçet’s disease is a systemic vasculitis that affects multiple organs. The most common manifestations are oral and genital ulcerations and recurrent uveitis. Uveitis can be an initial symptom in 10–20% of cases and leads to blindness in 16–25% of patients. The management of this disease is evolving due to the clinical phenotypes recently described in the literature and increasing focus on the detection of subclinical inflammation to enable correct therapeutic decisions. The first line treatment is azathioprine, followed by various immunosuppressive and biological agents as alternatives in severe or refractory cases. This review summarizes scientific articles about the etiology of, diagnostic tools for and treatment of the ocular manifestations of Behçet’s disease available in the PubMed database from 1 January 2016 to 1 May 2021. A multidisciplinary approach is necessary to effectively prevent permanent damage and thus improve the life quality of the patients. Therefore, it is crucial to raise awareness of the common clusters of symptoms, use of modern imaging methods, such as ocular computed tomography and fluorescein angiography, and novelty treatment algorithms to enable early diagnosis and appropriate management.https://www.mdpi.com/2077-0383/10/21/5174Behçet’s diseaseocular Behçetuveitismanagement of Behçet’s disease |
| spellingShingle | Hanna Zając Anna Turno-Kręcicka Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management Journal of Clinical Medicine Behçet’s disease ocular Behçet uveitis management of Behçet’s disease |
| title | Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management |
| title_full | Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management |
| title_fullStr | Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management |
| title_full_unstemmed | Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management |
| title_short | Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management |
| title_sort | ocular manifestations of behcet s disease an update on diagnostic challenges and disease management |
| topic | Behçet’s disease ocular Behçet uveitis management of Behçet’s disease |
| url | https://www.mdpi.com/2077-0383/10/21/5174 |
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