DIMEPHOSPHON EFFECTS ON SKIN MICROHAEMODYNAMICS
Aim. To demonstrate basic mechanisms of dimephosphon operation on skin microhaemodynamics.Materials and methods. The study of dimephosphon effect on blood microcirculation of skin in outbred male rats included registration of perfusion index, mean square deviation, variation coefficient; determinati...
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| Format: | Article |
| Language: | Russian |
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2017-11-01
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| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/892 |
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| author | E. N. CHUYAN M. Y. RAVAYEVA D. A. NEFEDOV A. V. ZELENSKAYA P. A. GALENKO-YAROSHEVSKY |
| author_facet | E. N. CHUYAN M. Y. RAVAYEVA D. A. NEFEDOV A. V. ZELENSKAYA P. A. GALENKO-YAROSHEVSKY |
| author_sort | E. N. CHUYAN |
| collection | DOAJ |
| description | Aim. To demonstrate basic mechanisms of dimephosphon operation on skin microhaemodynamics.Materials and methods. The study of dimephosphon effect on blood microcirculation of skin in outbred male rats included registration of perfusion index, mean square deviation, variation coefficient; determination of the amplitude of blood flow oscillations in different frequency range (by laser doppler flowmetry method).Results. Dimephosphon stimulates oscillatory and non-oscillatory skin microhaemodynamic indiсes indicating the increase of peripheral tissues perfusion and blood flow modulation in microvessels due to endothelium functional activity increase, peripheral resistance decrease, increase of blood flow to the nutritive microvessel channel and venous outflow improvement. Conclusion. Vasoactive properties of dimephosphon are manifested in its ability to affect vascular and extravascular regulatory processes of blood microcirculation of skin. Microvessel endothelium and its metabolic activity associated with NO release are the most sensitive to dimephosphon effect. The ability to increase endothelium NO production is the basic mechanism of dimephosphon vasodilatory action. |
| first_indexed | 2024-03-07T21:48:46Z |
| format | Article |
| id | doaj.art-b07c5eaa649d4a9899410787b8670cfa |
| institution | Directory Open Access Journal |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| last_indexed | 2024-03-07T21:48:46Z |
| publishDate | 2017-11-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj.art-b07c5eaa649d4a9899410787b8670cfa2024-02-25T10:57:21ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442017-11-0105909510.25207/1608-6228-2017-24-5-90-95826DIMEPHOSPHON EFFECTS ON SKIN MICROHAEMODYNAMICSE. N. CHUYAN0M. Y. RAVAYEVA1D. A. NEFEDOV2A. V. ZELENSKAYA3P. A. GALENKO-YAROSHEVSKY4Crimean Federal University Named After V.I. VernadskyCrimean Federal University Named After V.I. VernadskyKrasnodar Branch of FSBI “ISTC “Eye Microsurgery” named after acad. S.N. Fedorov, Ministry of Health Care of RussiaFederal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Healthcare of the Russian FederationFederal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Healthcare of the Russian FederationAim. To demonstrate basic mechanisms of dimephosphon operation on skin microhaemodynamics.Materials and methods. The study of dimephosphon effect on blood microcirculation of skin in outbred male rats included registration of perfusion index, mean square deviation, variation coefficient; determination of the amplitude of blood flow oscillations in different frequency range (by laser doppler flowmetry method).Results. Dimephosphon stimulates oscillatory and non-oscillatory skin microhaemodynamic indiсes indicating the increase of peripheral tissues perfusion and blood flow modulation in microvessels due to endothelium functional activity increase, peripheral resistance decrease, increase of blood flow to the nutritive microvessel channel and venous outflow improvement. Conclusion. Vasoactive properties of dimephosphon are manifested in its ability to affect vascular and extravascular regulatory processes of blood microcirculation of skin. Microvessel endothelium and its metabolic activity associated with NO release are the most sensitive to dimephosphon effect. The ability to increase endothelium NO production is the basic mechanism of dimephosphon vasodilatory action.https://ksma.elpub.ru/jour/article/view/892dimephosphonlaser doppler flowmetryskin microhaemodynamics |
| spellingShingle | E. N. CHUYAN M. Y. RAVAYEVA D. A. NEFEDOV A. V. ZELENSKAYA P. A. GALENKO-YAROSHEVSKY DIMEPHOSPHON EFFECTS ON SKIN MICROHAEMODYNAMICS Кубанский научный медицинский вестник dimephosphon laser doppler flowmetry skin microhaemodynamics |
| title | DIMEPHOSPHON EFFECTS ON SKIN MICROHAEMODYNAMICS |
| title_full | DIMEPHOSPHON EFFECTS ON SKIN MICROHAEMODYNAMICS |
| title_fullStr | DIMEPHOSPHON EFFECTS ON SKIN MICROHAEMODYNAMICS |
| title_full_unstemmed | DIMEPHOSPHON EFFECTS ON SKIN MICROHAEMODYNAMICS |
| title_short | DIMEPHOSPHON EFFECTS ON SKIN MICROHAEMODYNAMICS |
| title_sort | dimephosphon effects on skin microhaemodynamics |
| topic | dimephosphon laser doppler flowmetry skin microhaemodynamics |
| url | https://ksma.elpub.ru/jour/article/view/892 |
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