DNA repair genes XRCC1 and XRCC3 polymorphisms and their relationship with the level of micronuclei in breast cancer patients
Breast cancer (BC) is the most prevalent type worldwide, besides being one of the most common causes of death among women. It has been suggested that sporadic BC is most likely caused by low-penetrance genes, including those involved in DNA repair mechanisms. Furthermore, the accumulation of DNA dam...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2010-01-01
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| Series: | Genetics and Molecular Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000400007 |
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| author | Raquel A. Santos Ana Claudia Teixeira Monica B. Mayorano Helio H.A. Carrara Jurandyr M. Andrade Catarina S. Takahashi |
| author_facet | Raquel A. Santos Ana Claudia Teixeira Monica B. Mayorano Helio H.A. Carrara Jurandyr M. Andrade Catarina S. Takahashi |
| author_sort | Raquel A. Santos |
| collection | DOAJ |
| description | Breast cancer (BC) is the most prevalent type worldwide, besides being one of the most common causes of death among women. It has been suggested that sporadic BC is most likely caused by low-penetrance genes, including those involved in DNA repair mechanisms. Furthermore, the accumulation of DNA damage may contribute to breast carcinogenesis. In the present study, the relationship between two DNA repair genes, viz., XRCC1 (Arg399Gln) and XRCC3 (Thr241Met) polymorphisms, and the levels of chromosome damage detected in 65 untreated BC women and 85 healthy controls, was investigated. Chromosome damage was evaluated through micronucleus assaying, and genotypes determined by PCR-RFLP methodology. The results showed no alteration in the risk of BC and DNA damage brought about by either XRCC1 (Arg399Gln) or XRCC3 (Thr241Met) action in either of the two groups. Nevertheless, on evaluating BC risk in women presenting levels of chromosome damage above the mean, the XRCC3 Thr241Met polymorphism was found to be more frequent in the BC group than in the control, thereby leading to the conclusion that there is a slight association between XRCC3 (241 C/T) genotypes and BC risk in the subgroups with higher levels of chromosome damage. |
| first_indexed | 2024-12-23T20:44:50Z |
| format | Article |
| id | doaj.art-b07c6f1b2cc3495c8e9a26583bf1e71f |
| institution | Directory Open Access Journal |
| issn | 1415-4757 1678-4685 |
| language | English |
| last_indexed | 2024-12-23T20:44:50Z |
| publishDate | 2010-01-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-b07c6f1b2cc3495c8e9a26583bf1e71f2022-12-21T17:31:50ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46852010-01-01334637640DNA repair genes XRCC1 and XRCC3 polymorphisms and their relationship with the level of micronuclei in breast cancer patientsRaquel A. SantosAna Claudia TeixeiraMonica B. MayoranoHelio H.A. CarraraJurandyr M. AndradeCatarina S. TakahashiBreast cancer (BC) is the most prevalent type worldwide, besides being one of the most common causes of death among women. It has been suggested that sporadic BC is most likely caused by low-penetrance genes, including those involved in DNA repair mechanisms. Furthermore, the accumulation of DNA damage may contribute to breast carcinogenesis. In the present study, the relationship between two DNA repair genes, viz., XRCC1 (Arg399Gln) and XRCC3 (Thr241Met) polymorphisms, and the levels of chromosome damage detected in 65 untreated BC women and 85 healthy controls, was investigated. Chromosome damage was evaluated through micronucleus assaying, and genotypes determined by PCR-RFLP methodology. The results showed no alteration in the risk of BC and DNA damage brought about by either XRCC1 (Arg399Gln) or XRCC3 (Thr241Met) action in either of the two groups. Nevertheless, on evaluating BC risk in women presenting levels of chromosome damage above the mean, the XRCC3 Thr241Met polymorphism was found to be more frequent in the BC group than in the control, thereby leading to the conclusion that there is a slight association between XRCC3 (241 C/T) genotypes and BC risk in the subgroups with higher levels of chromosome damage.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000400007DNA repair polymorphismsbreast cancermicronucleus assay |
| spellingShingle | Raquel A. Santos Ana Claudia Teixeira Monica B. Mayorano Helio H.A. Carrara Jurandyr M. Andrade Catarina S. Takahashi DNA repair genes XRCC1 and XRCC3 polymorphisms and their relationship with the level of micronuclei in breast cancer patients Genetics and Molecular Biology DNA repair polymorphisms breast cancer micronucleus assay |
| title | DNA repair genes XRCC1 and XRCC3 polymorphisms and their relationship with the level of micronuclei in breast cancer patients |
| title_full | DNA repair genes XRCC1 and XRCC3 polymorphisms and their relationship with the level of micronuclei in breast cancer patients |
| title_fullStr | DNA repair genes XRCC1 and XRCC3 polymorphisms and their relationship with the level of micronuclei in breast cancer patients |
| title_full_unstemmed | DNA repair genes XRCC1 and XRCC3 polymorphisms and their relationship with the level of micronuclei in breast cancer patients |
| title_short | DNA repair genes XRCC1 and XRCC3 polymorphisms and their relationship with the level of micronuclei in breast cancer patients |
| title_sort | dna repair genes xrcc1 and xrcc3 polymorphisms and their relationship with the level of micronuclei in breast cancer patients |
| topic | DNA repair polymorphisms breast cancer micronucleus assay |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000400007 |
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