Improvement in Quality-of-Life-Related Outcomes Following Treatment with IncobotulinumtoxinA in Adults with Limb Spasticity: A Pooled Analysis
A strong correlation has been reported between patient-reported quality of life (QoL) and the investigator-rated Disability Assessment Scale (DAS) in patients with spasticity. The current analysis evaluates the effect of incobotulinumtoxinA on QoL-related outcomes (limb position abnormality, as well...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/16/1/19 |
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| author | Franco Molteni Jörg Wissel Klemens Fheodoroff Michael C. Munin Atul T. Patel Michael Althaus Georg Comes Andrzej Dekundy Irena Pulte Astrid Scheschonka Matteo Vacchelli Andrea Santamato |
| author_facet | Franco Molteni Jörg Wissel Klemens Fheodoroff Michael C. Munin Atul T. Patel Michael Althaus Georg Comes Andrzej Dekundy Irena Pulte Astrid Scheschonka Matteo Vacchelli Andrea Santamato |
| author_sort | Franco Molteni |
| collection | DOAJ |
| description | A strong correlation has been reported between patient-reported quality of life (QoL) and the investigator-rated Disability Assessment Scale (DAS) in patients with spasticity. The current analysis evaluates the effect of incobotulinumtoxinA on QoL-related outcomes (limb position abnormality, as well as dressing- and hygiene-related disability, measured with the DAS) in adults with upper limb spasticity, using pooled data from six studies. Separate analyses for each DAS domain were performed using data from patients with disabilities for that domain (DAS score ≥1). Results showed that a significantly greater proportion of incobotulinumtoxinA-treated compared with placebo-treated patients achieved a ≥1-point reduction from baseline in each of the DAS domains (improvement) 4 weeks after the first injection. The benefits of incobotulinumtoxinA were observed regardless of the baseline severity of DAS impairment and of the time elapsed since stroke. The effects of incobotulinumtoxinA 4 weeks after injection were maintained or enhanced over multiple injection cycles for all three DAS domains, supporting the use of repeated injection cycles to provide sustained QoL benefit. IncobotulinumtoxinA represents an important treatment option to achieve better QoL-related outcomes for patients with upper limb spasticity, irrespective of the duration of their condition. |
| first_indexed | 2024-03-08T10:33:42Z |
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| id | doaj.art-b07d75101faa40d3a967c412d70df326 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-08T10:33:42Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-b07d75101faa40d3a967c412d70df3262024-01-26T18:42:22ZengMDPI AGToxins2072-66512023-12-011611910.3390/toxins16010019Improvement in Quality-of-Life-Related Outcomes Following Treatment with IncobotulinumtoxinA in Adults with Limb Spasticity: A Pooled AnalysisFranco Molteni0Jörg Wissel1Klemens Fheodoroff2Michael C. Munin3Atul T. Patel4Michael Althaus5Georg Comes6Andrzej Dekundy7Irena Pulte8Astrid Scheschonka9Matteo Vacchelli10Andrea Santamato11Department of Rehabilitation, Valduce Villa Beretta Hospital, 23845 Costa Masnaga, ItalyDepartment of Neurorehabilitation and Physical Therapy, Vivantes Hospital Spandau, 13585 Berlin, GermanyGailtal-Klinik, A-9620 Hermagor, AustriaDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USAKansas City Bone and Joint Clinic, Overland Park, KS 66211, USAMerz Therapeutics GmbH, 60318 Frankfurt am Main, GermanyMerz Therapeutics GmbH, 60318 Frankfurt am Main, GermanyMerz Therapeutics GmbH, 60318 Frankfurt am Main, GermanyMerz Therapeutics GmbH, 60318 Frankfurt am Main, GermanyMerz Therapeutics GmbH, 60318 Frankfurt am Main, GermanyMerz Therapeutics GmbH, 60318 Frankfurt am Main, GermanyUnit of Spasticity and Movement Disorders, Division of Physical Medicine and Rehabilitation, University Hospital of Foggia, 71100 Foggia, ItalyA strong correlation has been reported between patient-reported quality of life (QoL) and the investigator-rated Disability Assessment Scale (DAS) in patients with spasticity. The current analysis evaluates the effect of incobotulinumtoxinA on QoL-related outcomes (limb position abnormality, as well as dressing- and hygiene-related disability, measured with the DAS) in adults with upper limb spasticity, using pooled data from six studies. Separate analyses for each DAS domain were performed using data from patients with disabilities for that domain (DAS score ≥1). Results showed that a significantly greater proportion of incobotulinumtoxinA-treated compared with placebo-treated patients achieved a ≥1-point reduction from baseline in each of the DAS domains (improvement) 4 weeks after the first injection. The benefits of incobotulinumtoxinA were observed regardless of the baseline severity of DAS impairment and of the time elapsed since stroke. The effects of incobotulinumtoxinA 4 weeks after injection were maintained or enhanced over multiple injection cycles for all three DAS domains, supporting the use of repeated injection cycles to provide sustained QoL benefit. IncobotulinumtoxinA represents an important treatment option to achieve better QoL-related outcomes for patients with upper limb spasticity, irrespective of the duration of their condition.https://www.mdpi.com/2072-6651/16/1/19upper limb spasticitybotulinum toxin type AincobotulinumtoxinAlimb positiondressinghygiene |
| spellingShingle | Franco Molteni Jörg Wissel Klemens Fheodoroff Michael C. Munin Atul T. Patel Michael Althaus Georg Comes Andrzej Dekundy Irena Pulte Astrid Scheschonka Matteo Vacchelli Andrea Santamato Improvement in Quality-of-Life-Related Outcomes Following Treatment with IncobotulinumtoxinA in Adults with Limb Spasticity: A Pooled Analysis Toxins upper limb spasticity botulinum toxin type A incobotulinumtoxinA limb position dressing hygiene |
| title | Improvement in Quality-of-Life-Related Outcomes Following Treatment with IncobotulinumtoxinA in Adults with Limb Spasticity: A Pooled Analysis |
| title_full | Improvement in Quality-of-Life-Related Outcomes Following Treatment with IncobotulinumtoxinA in Adults with Limb Spasticity: A Pooled Analysis |
| title_fullStr | Improvement in Quality-of-Life-Related Outcomes Following Treatment with IncobotulinumtoxinA in Adults with Limb Spasticity: A Pooled Analysis |
| title_full_unstemmed | Improvement in Quality-of-Life-Related Outcomes Following Treatment with IncobotulinumtoxinA in Adults with Limb Spasticity: A Pooled Analysis |
| title_short | Improvement in Quality-of-Life-Related Outcomes Following Treatment with IncobotulinumtoxinA in Adults with Limb Spasticity: A Pooled Analysis |
| title_sort | improvement in quality of life related outcomes following treatment with incobotulinumtoxina in adults with limb spasticity a pooled analysis |
| topic | upper limb spasticity botulinum toxin type A incobotulinumtoxinA limb position dressing hygiene |
| url | https://www.mdpi.com/2072-6651/16/1/19 |
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