Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases
Abstract Background Flavonols are phytoconstituents of biological and medicinal importance. In addition to functioning as antioxidants, flavonols may play a role in antagonizing diabetes, cancer, cardiovascular disease, and viral and bacterial diseases. Quercetin, myricetin, kaempferol, and fisetin...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-05-01
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| Series: | Beni-Suef University Journal of Basic and Applied Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43088-023-00387-4 |
| _version_ | 1797822756798070784 |
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| author | Aar Rafi Mahmud Tanzila Ismail Ema Mohd. Faijanur - Rob Siddiquee Asif Shahriar Hossain Ahmed Md. Mosfeq-Ul-Hasan Nova Rahman Rahatul Islam Muhammad Ramiz Uddin Md. Furkanur Rahaman Mizan |
| author_facet | Aar Rafi Mahmud Tanzila Ismail Ema Mohd. Faijanur - Rob Siddiquee Asif Shahriar Hossain Ahmed Md. Mosfeq-Ul-Hasan Nova Rahman Rahatul Islam Muhammad Ramiz Uddin Md. Furkanur Rahaman Mizan |
| author_sort | Aar Rafi Mahmud |
| collection | DOAJ |
| description | Abstract Background Flavonols are phytoconstituents of biological and medicinal importance. In addition to functioning as antioxidants, flavonols may play a role in antagonizing diabetes, cancer, cardiovascular disease, and viral and bacterial diseases. Quercetin, myricetin, kaempferol, and fisetin are the major dietary flavonols. Quercetin is a potent scavenger of free radicals, providing protection from free radical damage and oxidation-associated diseases. Main body of the abstract An extensive literature review of specific databases (e.g., Pubmed, google scholar, science direct) were conducted using the keywords “flavonol,” “quercetin,” “antidiabetic,” “antiviral,” “anticancer,” and “myricetin.” Some studies concluded that quercetin is a promising antioxidant agent while kaempferol could be effective against human gastric cancer. In addition, kaempferol prevents apoptosis of pancreatic beta-cells via boosting the function and survival rate of the beta-cells, leading to increased insulin secretion. Flavonols also show potential as alternatives to conventional antibiotics, restricting viral infection by antagonizing the envelope proteins to block viral entry. Short conclusion There is substantial scientific evidence that high consumption of flavonols is associated with reduced risk of cancer and coronary diseases, free radical damage alleviation, tumor growth prevention, and insulin secretion improvement, among other diverse health benefits. Nevertheless, more studies are required to determine the appropriate dietary concentration, dose, and type of flavonol for a particular condition to prevent any adverse side effects. |
| first_indexed | 2024-03-13T10:13:51Z |
| format | Article |
| id | doaj.art-b0852ae5aab045e09952c4f7c2eddfcf |
| institution | Directory Open Access Journal |
| issn | 2314-8543 |
| language | English |
| last_indexed | 2024-03-13T10:13:51Z |
| publishDate | 2023-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Beni-Suef University Journal of Basic and Applied Sciences |
| spelling | doaj.art-b0852ae5aab045e09952c4f7c2eddfcf2023-05-21T11:23:27ZengSpringerOpenBeni-Suef University Journal of Basic and Applied Sciences2314-85432023-05-0112111810.1186/s43088-023-00387-4Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseasesAar Rafi Mahmud0Tanzila Ismail Ema1Mohd. Faijanur - Rob Siddiquee2Asif Shahriar3Hossain Ahmed4Md. Mosfeq-Ul-Hasan5Nova Rahman6Rahatul Islam7Muhammad Ramiz Uddin8Md. Furkanur Rahaman Mizan9Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology UniversityDepartment of Biochemistry and Microbiology, North South UniversityDepartment of Biochemistry and Molecular Biology, University of DhakaDepartment of Microbiology, Stamford University BangladeshDepartment of Biotechnology and Genetic Engineering, University of Development Alternative (UODA)Hajee Mohammad Danesh Science and Technology UniversityDepartment of Biochemistry and Molecular Biology, Jahangirnagar UniversityDepartment of Genetic Engineering and Biotechnology, Shahjalal University of Science and TechnologyDepartment of Pharmacy, Jahangirnagar UniversityDepartment of Food Science and Technology, Chung-Ang UniversityAbstract Background Flavonols are phytoconstituents of biological and medicinal importance. In addition to functioning as antioxidants, flavonols may play a role in antagonizing diabetes, cancer, cardiovascular disease, and viral and bacterial diseases. Quercetin, myricetin, kaempferol, and fisetin are the major dietary flavonols. Quercetin is a potent scavenger of free radicals, providing protection from free radical damage and oxidation-associated diseases. Main body of the abstract An extensive literature review of specific databases (e.g., Pubmed, google scholar, science direct) were conducted using the keywords “flavonol,” “quercetin,” “antidiabetic,” “antiviral,” “anticancer,” and “myricetin.” Some studies concluded that quercetin is a promising antioxidant agent while kaempferol could be effective against human gastric cancer. In addition, kaempferol prevents apoptosis of pancreatic beta-cells via boosting the function and survival rate of the beta-cells, leading to increased insulin secretion. Flavonols also show potential as alternatives to conventional antibiotics, restricting viral infection by antagonizing the envelope proteins to block viral entry. Short conclusion There is substantial scientific evidence that high consumption of flavonols is associated with reduced risk of cancer and coronary diseases, free radical damage alleviation, tumor growth prevention, and insulin secretion improvement, among other diverse health benefits. Nevertheless, more studies are required to determine the appropriate dietary concentration, dose, and type of flavonol for a particular condition to prevent any adverse side effects.https://doi.org/10.1186/s43088-023-00387-4FlavonolQuercetinMyricetinKaempferolAntioxidant |
| spellingShingle | Aar Rafi Mahmud Tanzila Ismail Ema Mohd. Faijanur - Rob Siddiquee Asif Shahriar Hossain Ahmed Md. Mosfeq-Ul-Hasan Nova Rahman Rahatul Islam Muhammad Ramiz Uddin Md. Furkanur Rahaman Mizan Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases Beni-Suef University Journal of Basic and Applied Sciences Flavonol Quercetin Myricetin Kaempferol Antioxidant |
| title | Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases |
| title_full | Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases |
| title_fullStr | Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases |
| title_full_unstemmed | Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases |
| title_short | Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases |
| title_sort | natural flavonols actions mechanisms and potential therapeutic utility for various diseases |
| topic | Flavonol Quercetin Myricetin Kaempferol Antioxidant |
| url | https://doi.org/10.1186/s43088-023-00387-4 |
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