Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine
The authors have previously demonstrated the neutralising capacity of their nanoparticle vaccine, as well as showing protection of non-human primates from SARS-CoV-2 WA-1 infection. In this work, they investigate the ability of their vaccine candidate to neutralise SARS-CoV-2 variants of concern, an...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33985-4 |
| _version_ | 1797985983217532928 |
|---|---|
| author | Dapeng Li David R. Martinez Alexandra Schäfer Haiyan Chen Maggie Barr Laura L. Sutherland Esther Lee Robert Parks Dieter Mielke Whitney Edwards Amanda Newman Kevin W. Bock Mahnaz Minai Bianca M. Nagata Matthew Gagne Daniel C. Douek C. Todd DeMarco Thomas N. Denny Thomas H. Oguin Alecia Brown Wes Rountree Yunfei Wang Katayoun Mansouri Robert J. Edwards Guido Ferrari Gregory D. Sempowski Amanda Eaton Juanjie Tang Derek W. Cain Sampa Santra Norbert Pardi Drew Weissman Mark A. Tomai Christopher B. Fox Ian N. Moore Hanne Andersen Mark G. Lewis Hana Golding Robert Seder Surender Khurana Ralph S. Baric David C. Montefiori Kevin O. Saunders Barton F. Haynes |
| author_facet | Dapeng Li David R. Martinez Alexandra Schäfer Haiyan Chen Maggie Barr Laura L. Sutherland Esther Lee Robert Parks Dieter Mielke Whitney Edwards Amanda Newman Kevin W. Bock Mahnaz Minai Bianca M. Nagata Matthew Gagne Daniel C. Douek C. Todd DeMarco Thomas N. Denny Thomas H. Oguin Alecia Brown Wes Rountree Yunfei Wang Katayoun Mansouri Robert J. Edwards Guido Ferrari Gregory D. Sempowski Amanda Eaton Juanjie Tang Derek W. Cain Sampa Santra Norbert Pardi Drew Weissman Mark A. Tomai Christopher B. Fox Ian N. Moore Hanne Andersen Mark G. Lewis Hana Golding Robert Seder Surender Khurana Ralph S. Baric David C. Montefiori Kevin O. Saunders Barton F. Haynes |
| author_sort | Dapeng Li |
| collection | DOAJ |
| description | The authors have previously demonstrated the neutralising capacity of their nanoparticle vaccine, as well as showing protection of non-human primates from SARS-CoV-2 WA-1 infection. In this work, they investigate the ability of their vaccine candidate to neutralise SARS-CoV-2 variants of concern, and protect animals from other sarbecoviruses. |
| first_indexed | 2024-04-11T07:26:46Z |
| format | Article |
| id | doaj.art-b08586c46f7c4fa6b00bfd070a9caed1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T07:26:46Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b08586c46f7c4fa6b00bfd070a9caed12022-12-22T04:37:04ZengNature PortfolioNature Communications2041-17232022-10-0113111510.1038/s41467-022-33985-4Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccineDapeng Li0David R. Martinez1Alexandra Schäfer2Haiyan Chen3Maggie Barr4Laura L. Sutherland5Esther Lee6Robert Parks7Dieter Mielke8Whitney Edwards9Amanda Newman10Kevin W. Bock11Mahnaz Minai12Bianca M. Nagata13Matthew Gagne14Daniel C. Douek15C. Todd DeMarco16Thomas N. Denny17Thomas H. Oguin18Alecia Brown19Wes Rountree20Yunfei Wang21Katayoun Mansouri22Robert J. Edwards23Guido Ferrari24Gregory D. Sempowski25Amanda Eaton26Juanjie Tang27Derek W. Cain28Sampa Santra29Norbert Pardi30Drew Weissman31Mark A. Tomai32Christopher B. Fox33Ian N. Moore34Hanne Andersen35Mark G. Lewis36Hana Golding37Robert Seder38Surender Khurana39Ralph S. Baric40David C. Montefiori41Kevin O. Saunders42Barton F. Haynes43Duke Human Vaccine Institute, Duke University School of MedicineDepartment of Epidemiology, University of North Carolina at Chapel HillDepartment of Epidemiology, University of North Carolina at Chapel HillDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDepartment of Surgery, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineInfectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of HealthInfectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of HealthInfectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of HealthVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of HealthVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of HealthDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug AdministrationDuke Human Vaccine Institute, Duke University School of MedicineBeth Israel Deaconess Medical CenterDepartment of Microbiology, University of PennsylvaniaDepartment of Medicine, University of PennsylvaniaCorporate Research Materials Lab, 3M CompanyInfectious Disease Research InstituteInfectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of HealthBIOQUALBIOQUALDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug AdministrationVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of HealthDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug AdministrationDepartment of Epidemiology, University of North Carolina at Chapel HillDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of MedicineThe authors have previously demonstrated the neutralising capacity of their nanoparticle vaccine, as well as showing protection of non-human primates from SARS-CoV-2 WA-1 infection. In this work, they investigate the ability of their vaccine candidate to neutralise SARS-CoV-2 variants of concern, and protect animals from other sarbecoviruses.https://doi.org/10.1038/s41467-022-33985-4 |
| spellingShingle | Dapeng Li David R. Martinez Alexandra Schäfer Haiyan Chen Maggie Barr Laura L. Sutherland Esther Lee Robert Parks Dieter Mielke Whitney Edwards Amanda Newman Kevin W. Bock Mahnaz Minai Bianca M. Nagata Matthew Gagne Daniel C. Douek C. Todd DeMarco Thomas N. Denny Thomas H. Oguin Alecia Brown Wes Rountree Yunfei Wang Katayoun Mansouri Robert J. Edwards Guido Ferrari Gregory D. Sempowski Amanda Eaton Juanjie Tang Derek W. Cain Sampa Santra Norbert Pardi Drew Weissman Mark A. Tomai Christopher B. Fox Ian N. Moore Hanne Andersen Mark G. Lewis Hana Golding Robert Seder Surender Khurana Ralph S. Baric David C. Montefiori Kevin O. Saunders Barton F. Haynes Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine Nature Communications |
| title | Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine |
| title_full | Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine |
| title_fullStr | Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine |
| title_full_unstemmed | Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine |
| title_short | Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine |
| title_sort | breadth of sars cov 2 neutralization and protection induced by a nanoparticle vaccine |
| url | https://doi.org/10.1038/s41467-022-33985-4 |
| work_keys_str_mv | AT dapengli breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT davidrmartinez breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT alexandraschafer breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT haiyanchen breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT maggiebarr breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT lauralsutherland breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT estherlee breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT robertparks breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT dietermielke breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT whitneyedwards breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT amandanewman breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT kevinwbock breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT mahnazminai breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT biancamnagata breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT matthewgagne breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT danielcdouek breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT ctodddemarco breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT thomasndenny breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT thomashoguin breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT aleciabrown breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT wesrountree breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT yunfeiwang breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT katayounmansouri breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT robertjedwards breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT guidoferrari breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT gregorydsempowski breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT amandaeaton breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT juanjietang breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT derekwcain breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT sampasantra breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT norbertpardi breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT drewweissman breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT markatomai breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT christopherbfox breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT iannmoore breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT hanneandersen breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT markglewis breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT hanagolding breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT robertseder breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT surenderkhurana breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT ralphsbaric breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT davidcmontefiori breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT kevinosaunders breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine AT bartonfhaynes breadthofsarscov2neutralizationandprotectioninducedbyananoparticlevaccine |