Inward Operation of Sodium-Bicarbonate Cotransporter 1 Promotes Astrocytic Na<sup>+</sup> Loading and Loss of ATP in Mouse Neocortex during Brief Chemical Ischemia

Inward Operation of Sodium-Bicarbonate Cotransporter 1 Promotes Astrocytic Na<sup>+</sup> Loading and Loss of ATP in Mouse Neocortex during Brief Chemical Ischemia

Ischemic conditions cause an increase in the sodium concentration of astrocytes, driving the breakdown of ionic homeostasis and exacerbating cellular damage. Astrocytes express high levels of the electrogenic sodium-bicarbonate cotransporter1 (NBCe1), which couples intracellular Na<sup>+</s...

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Bibliographic Details
Main Authors: Katharina Everaerts, Pawan Thapaliya, Nils Pape, Simone Durry, Sara Eitelmann, Eleni Roussa, Ghanim Ullah, Christine R. Rose
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
astrocyte
sodium
pH
neocortex
ischemia
ATP
Online Access:https://www.mdpi.com/2073-4409/12/23/2675

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