DNA Methylation: A Potential Biomarker of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a serious public health concern worldwide. By 2040, 4.41 million people are estimated to expire annually due to COPD. However, till date, it has remained difficult to alter the activity or progress of the disease through treatment. In order to address...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.00585/full |
| _version_ | 1818192687985065984 |
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| author | Lin-Xi He Zhao-Hui Tang Qing-Song Huang Wei-Hong Li |
| author_facet | Lin-Xi He Zhao-Hui Tang Qing-Song Huang Wei-Hong Li |
| author_sort | Lin-Xi He |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is a serious public health concern worldwide. By 2040, 4.41 million people are estimated to expire annually due to COPD. However, till date, it has remained difficult to alter the activity or progress of the disease through treatment. In order to address this issue, the best way would be to find biomarkers and new therapeutic targets for COPD. DNA methylation (DNAm) may be a potential biomarker for disease prevention, diagnosis, and prognosis, and its reversibility further makes it a potential drug design target in COPD. In this review, we aimed to explore the role of DNAm as biomarkers and disease mediators in different tissue samples from patients with COPD. |
| first_indexed | 2024-12-12T00:34:28Z |
| format | Article |
| id | doaj.art-b088d47f59854dcfb73c620044d81a13 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T00:34:28Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-b088d47f59854dcfb73c620044d81a132022-12-22T00:44:23ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-07-01810.3389/fcell.2020.00585560112DNA Methylation: A Potential Biomarker of Chronic Obstructive Pulmonary DiseaseLin-Xi He0Zhao-Hui Tang1Qing-Song Huang2Wei-Hong Li3School of Basic Medicine Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Basic Medicine Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Respiratory, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Basic Medicine Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaChronic obstructive pulmonary disease (COPD) is a serious public health concern worldwide. By 2040, 4.41 million people are estimated to expire annually due to COPD. However, till date, it has remained difficult to alter the activity or progress of the disease through treatment. In order to address this issue, the best way would be to find biomarkers and new therapeutic targets for COPD. DNA methylation (DNAm) may be a potential biomarker for disease prevention, diagnosis, and prognosis, and its reversibility further makes it a potential drug design target in COPD. In this review, we aimed to explore the role of DNAm as biomarkers and disease mediators in different tissue samples from patients with COPD.https://www.frontiersin.org/article/10.3389/fcell.2020.00585/fullDNA methylationCOPDbiomarkertissue specificitylung cancer |
| spellingShingle | Lin-Xi He Zhao-Hui Tang Qing-Song Huang Wei-Hong Li DNA Methylation: A Potential Biomarker of Chronic Obstructive Pulmonary Disease Frontiers in Cell and Developmental Biology DNA methylation COPD biomarker tissue specificity lung cancer |
| title | DNA Methylation: A Potential Biomarker of Chronic Obstructive Pulmonary Disease |
| title_full | DNA Methylation: A Potential Biomarker of Chronic Obstructive Pulmonary Disease |
| title_fullStr | DNA Methylation: A Potential Biomarker of Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | DNA Methylation: A Potential Biomarker of Chronic Obstructive Pulmonary Disease |
| title_short | DNA Methylation: A Potential Biomarker of Chronic Obstructive Pulmonary Disease |
| title_sort | dna methylation a potential biomarker of chronic obstructive pulmonary disease |
| topic | DNA methylation COPD biomarker tissue specificity lung cancer |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.00585/full |
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