Methylglyoxal (MG) and Cerebro-Renal Interaction: Does Long-Term Orally Administered MG Cause Cognitive Impairment in Normal Sprague-Dawley Rats?

Methylglyoxal (MG) and Cerebro-Renal Interaction: Does Long-Term Orally Administered MG Cause Cognitive Impairment in Normal Sprague-Dawley Rats?

Methylglyoxal (MG), one of the uremic toxins, is a highly reactive alpha-dicarbonyl compound. Recent clinical studies have demonstrated the close associations of cognitive impairment (CI) with plasma MG levels and presence of kidney dysfunction. Therefore, the present study aims to examine whether M...

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Bibliographic Details
Main Authors: Kimio Watanabe, Kana Okada, Ryoji Fukabori, Yoshimitsu Hayashi, Koichi Asahi, Hiroyuki Terawaki, Kazuto Kobayashi, Tsuyoshi Watanabe, Masaaki Nakayama
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Toxins
Subjects:
cerebro-renal interaction
methylglyoxal
cognitive impairment
chronic kidney disease
Online Access:http://www.mdpi.com/2072-6651/6/1/254

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