Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program.
A set of 908 clinically derived colistin-resistant Enterobacteriaeae isolates collected worldwide in 2014-2016 were screened for the presence of the plasmid-borne mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 genes. In total 3.2% (29/908) of the collection were positive for mcr, including 27 Escherichia coli...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5880376?pdf=render |
| _version_ | 1828749708143624192 |
|---|---|
| author | Mark G Wise Mark A Estabrook Daniel F Sahm Gregory G Stone Krystyna M Kazmierczak |
| author_facet | Mark G Wise Mark A Estabrook Daniel F Sahm Gregory G Stone Krystyna M Kazmierczak |
| author_sort | Mark G Wise |
| collection | DOAJ |
| description | A set of 908 clinically derived colistin-resistant Enterobacteriaeae isolates collected worldwide in 2014-2016 were screened for the presence of the plasmid-borne mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 genes. In total 3.2% (29/908) of the collection were positive for mcr, including 27 Escherichia coli, 1 Klebsiella pneumoniae and 1 Enterobacter cloacae. Twenty-four isolates possessed genes from the mcr-1 family, including the original mcr-1 (n = 22), as well as mcr-1.2 (n = 1) and mcr-1.5 (n = 1), which each differ from mcr-1 by encoding single amino acid variations. Genes from the mcr-3 family were found in isolates from Thailand, including mcr-3.1 (n = 3) and mcr-3.2 (n = 1). An E. coli isolated from a patient with a urinary tract infection in Colombia contained the recently discovered mcr-5. The full colistin-resistant collection was tested against a panel of antimicrobial agents with ceftazidime-avibactam and tigecycline exhibiting the highest activity. |
| first_indexed | 2024-12-10T20:27:11Z |
| format | Article |
| id | doaj.art-b08be3500e4045ffa989d79f58c86cd6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T20:27:11Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b08be3500e4045ffa989d79f58c86cd62022-12-22T01:34:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01134e019528110.1371/journal.pone.0195281Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program.Mark G WiseMark A EstabrookDaniel F SahmGregory G StoneKrystyna M KazmierczakA set of 908 clinically derived colistin-resistant Enterobacteriaeae isolates collected worldwide in 2014-2016 were screened for the presence of the plasmid-borne mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 genes. In total 3.2% (29/908) of the collection were positive for mcr, including 27 Escherichia coli, 1 Klebsiella pneumoniae and 1 Enterobacter cloacae. Twenty-four isolates possessed genes from the mcr-1 family, including the original mcr-1 (n = 22), as well as mcr-1.2 (n = 1) and mcr-1.5 (n = 1), which each differ from mcr-1 by encoding single amino acid variations. Genes from the mcr-3 family were found in isolates from Thailand, including mcr-3.1 (n = 3) and mcr-3.2 (n = 1). An E. coli isolated from a patient with a urinary tract infection in Colombia contained the recently discovered mcr-5. The full colistin-resistant collection was tested against a panel of antimicrobial agents with ceftazidime-avibactam and tigecycline exhibiting the highest activity.http://europepmc.org/articles/PMC5880376?pdf=render |
| spellingShingle | Mark G Wise Mark A Estabrook Daniel F Sahm Gregory G Stone Krystyna M Kazmierczak Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program. PLoS ONE |
| title | Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program. |
| title_full | Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program. |
| title_fullStr | Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program. |
| title_full_unstemmed | Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program. |
| title_short | Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program. |
| title_sort | prevalence of mcr type genes among colistin resistant enterobacteriaceae collected in 2014 2016 as part of the inform global surveillance program |
| url | http://europepmc.org/articles/PMC5880376?pdf=render |
| work_keys_str_mv | AT markgwise prevalenceofmcrtypegenesamongcolistinresistantenterobacteriaceaecollectedin20142016aspartoftheinformglobalsurveillanceprogram AT markaestabrook prevalenceofmcrtypegenesamongcolistinresistantenterobacteriaceaecollectedin20142016aspartoftheinformglobalsurveillanceprogram AT danielfsahm prevalenceofmcrtypegenesamongcolistinresistantenterobacteriaceaecollectedin20142016aspartoftheinformglobalsurveillanceprogram AT gregorygstone prevalenceofmcrtypegenesamongcolistinresistantenterobacteriaceaecollectedin20142016aspartoftheinformglobalsurveillanceprogram AT krystynamkazmierczak prevalenceofmcrtypegenesamongcolistinresistantenterobacteriaceaecollectedin20142016aspartoftheinformglobalsurveillanceprogram |