Effect of Glucose Improvement on Nocturnal Sleep Breathing Parameters in Patients with Type 2 Diabetes: The Candy Dreams Study
Type 2 diabetes exerts a negative impact on sleep breathing. It is unknown whether a long-term improvement in glycemic control ameliorates this effect. We conducted an interventional study with 35 patients with type 2 diabetes and obstructive sleep apnea (OSA) to explore this. At home, sleep breathi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/4/1022 |
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| author | Liliana Gutiérrez-Carrasquilla Carolina López-Cano Enric Sánchez Ferran Barbé Mireia Dalmases Marta Hernández Angela Campos Anna Michaela Gaeta Paola Carmona Cristina Hernández Rafael Simó Albert Lecube |
| author_facet | Liliana Gutiérrez-Carrasquilla Carolina López-Cano Enric Sánchez Ferran Barbé Mireia Dalmases Marta Hernández Angela Campos Anna Michaela Gaeta Paola Carmona Cristina Hernández Rafael Simó Albert Lecube |
| author_sort | Liliana Gutiérrez-Carrasquilla |
| collection | DOAJ |
| description | Type 2 diabetes exerts a negative impact on sleep breathing. It is unknown whether a long-term improvement in glycemic control ameliorates this effect. We conducted an interventional study with 35 patients with type 2 diabetes and obstructive sleep apnea (OSA) to explore this. At home, sleep breathing parameters were assessed at baseline and after a 4-month period in which antidiabetic therapy was intensified. Patients who decreased their body mass index ≥2kg/m<sup>2</sup> were excluded. Those with an HbA1c reduction ≥0.5% were considered good responders (<i>n</i> = 24). After the follow-up, good responders exhibited an improvement in the apnea–hypopnea index (AHI: 26-1 (95% IC: 8.6–95.0) vs. 20.0 (4.0–62.4) events/hour, <i>p</i> = 0.002) and in time with oxygen saturation below 90% (CT90: 13.3 (0.4–69.0) vs. 8.1 (0.4–71.2) %, <i>p</i> = 0.002). No changes were observed in the group of non–responders (<i>p</i> = 0.722 and <i>p</i> = 0.138, respectively). The percentage of moderate and severe OSA decreased among good responders (<i>p</i> = 0.040). In the wider population, the change in HbA1c correlated positively to decreases in AHI (r = 0.358, <i>p</i> = 0.035) and negatively to increases in the minimum arterial oxygen saturation (r = −0.386, <i>p</i> = 0.039). Stepwise multivariate regression analysis showed that baseline AHI and the absolute change in HbA1c independently predicted decreased AHI (R<sup>2</sup> = 0.496). The improvement of glycemic control exerts beneficial effects on sleep breathing parameters in type 2 diabetes, which cannot be attributed merely to weight loss. |
| first_indexed | 2024-03-10T20:40:20Z |
| format | Article |
| id | doaj.art-b08c4372df974c69bc6e273dc6b27966 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T20:40:20Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b08c4372df974c69bc6e273dc6b279662023-11-19T20:43:22ZengMDPI AGJournal of Clinical Medicine2077-03832020-04-0194102210.3390/jcm9041022Effect of Glucose Improvement on Nocturnal Sleep Breathing Parameters in Patients with Type 2 Diabetes: The Candy Dreams StudyLiliana Gutiérrez-Carrasquilla0Carolina López-Cano1Enric Sánchez2Ferran Barbé3Mireia Dalmases4Marta Hernández5Angela Campos6Anna Michaela Gaeta7Paola Carmona8Cristina Hernández9Rafael Simó10Albert Lecube11Endocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) research group, IRBLleida, University of Lleida, 25198 Lleida, SpainEndocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) research group, IRBLleida, University of Lleida, 25198 Lleida, SpainEndocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) research group, IRBLleida, University of Lleida, 25198 Lleida, SpainRespiratory Department, University Hospital Arnau de Vilanova-Santa María, Translational Research in Respiratory Medicine, IRBLleida, University of Lleida, 25198 Lleida, SpainRespiratory Department, University Hospital Arnau de Vilanova-Santa María, Translational Research in Respiratory Medicine, IRBLleida, University of Lleida, 25198 Lleida, SpainEndocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) research group, IRBLleida, University of Lleida, 25198 Lleida, SpainEndocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) research group, IRBLleida, University of Lleida, 25198 Lleida, SpainRespiratory Department, University Hospital Arnau de Vilanova-Santa María, Translational Research in Respiratory Medicine, IRBLleida, University of Lleida, 25198 Lleida, SpainRespiratory Department, University Hospital Arnau de Vilanova-Santa María, Translational Research in Respiratory Medicine, IRBLleida, University of Lleida, 25198 Lleida, SpainEndocrinology and Nutrition Department, University Hospital Vall d’Hebron, Diabetes and Metabolism Research Unit, Vall d’Hebron Institut de Recerca (VHIR), Autonomous University of Barcelona, 08035 Barcelona, SpainEndocrinology and Nutrition Department, University Hospital Vall d’Hebron, Diabetes and Metabolism Research Unit, Vall d’Hebron Institut de Recerca (VHIR), Autonomous University of Barcelona, 08035 Barcelona, SpainEndocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) research group, IRBLleida, University of Lleida, 25198 Lleida, SpainType 2 diabetes exerts a negative impact on sleep breathing. It is unknown whether a long-term improvement in glycemic control ameliorates this effect. We conducted an interventional study with 35 patients with type 2 diabetes and obstructive sleep apnea (OSA) to explore this. At home, sleep breathing parameters were assessed at baseline and after a 4-month period in which antidiabetic therapy was intensified. Patients who decreased their body mass index ≥2kg/m<sup>2</sup> were excluded. Those with an HbA1c reduction ≥0.5% were considered good responders (<i>n</i> = 24). After the follow-up, good responders exhibited an improvement in the apnea–hypopnea index (AHI: 26-1 (95% IC: 8.6–95.0) vs. 20.0 (4.0–62.4) events/hour, <i>p</i> = 0.002) and in time with oxygen saturation below 90% (CT90: 13.3 (0.4–69.0) vs. 8.1 (0.4–71.2) %, <i>p</i> = 0.002). No changes were observed in the group of non–responders (<i>p</i> = 0.722 and <i>p</i> = 0.138, respectively). The percentage of moderate and severe OSA decreased among good responders (<i>p</i> = 0.040). In the wider population, the change in HbA1c correlated positively to decreases in AHI (r = 0.358, <i>p</i> = 0.035) and negatively to increases in the minimum arterial oxygen saturation (r = −0.386, <i>p</i> = 0.039). Stepwise multivariate regression analysis showed that baseline AHI and the absolute change in HbA1c independently predicted decreased AHI (R<sup>2</sup> = 0.496). The improvement of glycemic control exerts beneficial effects on sleep breathing parameters in type 2 diabetes, which cannot be attributed merely to weight loss.https://www.mdpi.com/2077-0383/9/4/1022diabetesapneahypoxiaglycated hemoglobin |
| spellingShingle | Liliana Gutiérrez-Carrasquilla Carolina López-Cano Enric Sánchez Ferran Barbé Mireia Dalmases Marta Hernández Angela Campos Anna Michaela Gaeta Paola Carmona Cristina Hernández Rafael Simó Albert Lecube Effect of Glucose Improvement on Nocturnal Sleep Breathing Parameters in Patients with Type 2 Diabetes: The Candy Dreams Study Journal of Clinical Medicine diabetes apnea hypoxia glycated hemoglobin |
| title | Effect of Glucose Improvement on Nocturnal Sleep Breathing Parameters in Patients with Type 2 Diabetes: The Candy Dreams Study |
| title_full | Effect of Glucose Improvement on Nocturnal Sleep Breathing Parameters in Patients with Type 2 Diabetes: The Candy Dreams Study |
| title_fullStr | Effect of Glucose Improvement on Nocturnal Sleep Breathing Parameters in Patients with Type 2 Diabetes: The Candy Dreams Study |
| title_full_unstemmed | Effect of Glucose Improvement on Nocturnal Sleep Breathing Parameters in Patients with Type 2 Diabetes: The Candy Dreams Study |
| title_short | Effect of Glucose Improvement on Nocturnal Sleep Breathing Parameters in Patients with Type 2 Diabetes: The Candy Dreams Study |
| title_sort | effect of glucose improvement on nocturnal sleep breathing parameters in patients with type 2 diabetes the candy dreams study |
| topic | diabetes apnea hypoxia glycated hemoglobin |
| url | https://www.mdpi.com/2077-0383/9/4/1022 |
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