Preclinical and Early Clinical Development of Tenofovir Alafenamide/Elvitegravir Topical Inserts for Effective On-Demand Vaginal and Rectal HIV Prevention

Preclinical and Early Clinical Development of Tenofovir Alafenamide/Elvitegravir Topical Inserts for Effective On-Demand Vaginal and Rectal HIV Prevention

HIV/AIDS remains a global public health issue, and products available for the prevention of HIV infections are limited, especially those for short-acting, on-demand, user-controlled applications. Topical inserts are products that can be applied vaginally or rectally and have been explored as drug de...

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Bibliographic Details
Main Authors: M. Melissa Peet, Vivek Agrahari, Meredith R. Clark, Gustavo F. Doncel
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Pharmaceutics
Subjects:
HIV pre-exposure and post-exposure prophylaxis
topical PrEP and PEP
antiretrovirals
acceptability
safety
Online Access:https://www.mdpi.com/1999-4923/16/3/348

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