A Machine Learning Framework Predicts the Clinical Severity of Hemophilia B Caused by Point-Mutations

A Machine Learning Framework Predicts the Clinical Severity of Hemophilia B Caused by Point-Mutations

Blood coagulation is a vital physiological mechanism to stop blood loss following an injury to a blood vessel. This process starts immediately upon damage to the endothelium lining a blood vessel, and results in the formation of a platelet plug that closes the site of injury. In this repair operatio...

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Bibliographic Details
Main Authors: Tiago J. S. Lopes, Tatiane Nogueira, Ricardo Rios
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Bioinformatics
Subjects:
hemophilia B
protein structure
machine learning
bioinformatics
residue network
FIX
Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2022.912112/full

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