Application of magnetic nanoparticles in nucleic acid detection
Abstract Nucleic acid is the main material for storing, copying, and transmitting genetic information. Gene sequencing is of great significance in DNA damage research, gene therapy, mutation analysis, bacterial infection, drug development, and clinical diagnosis. Gene detection has a wide range of a...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12951-020-00613-6 |
| _version_ | 1818036235838423040 |
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| author | Congli Tang Ziyu He Hongmei Liu Yuyue Xu Hao Huang Gaojian Yang Ziqi Xiao Song Li Hongna Liu Yan Deng Zhu Chen Hui Chen Nongyue He |
| author_facet | Congli Tang Ziyu He Hongmei Liu Yuyue Xu Hao Huang Gaojian Yang Ziqi Xiao Song Li Hongna Liu Yan Deng Zhu Chen Hui Chen Nongyue He |
| author_sort | Congli Tang |
| collection | DOAJ |
| description | Abstract Nucleic acid is the main material for storing, copying, and transmitting genetic information. Gene sequencing is of great significance in DNA damage research, gene therapy, mutation analysis, bacterial infection, drug development, and clinical diagnosis. Gene detection has a wide range of applications, such as environmental, biomedical, pharmaceutical, agriculture and forensic medicine to name a few. Compared with Sanger sequencing, high-throughput sequencing technology has the advantages of larger output, high resolution, and low cost which greatly promotes the application of sequencing technology in life science research. Magnetic nanoparticles, as an important part of nanomaterials, have been widely used in various applications because of their good dispersion, high surface area, low cost, easy separation in buffer systems and signal detection. Based on the above, the application of magnetic nanoparticles in nucleic acid detection was reviewed. |
| first_indexed | 2024-12-10T07:07:44Z |
| format | Article |
| id | doaj.art-b091a7a3d986459b98f48a871be7532f |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-12-10T07:07:44Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-b091a7a3d986459b98f48a871be7532f2022-12-22T01:58:08ZengBMCJournal of Nanobiotechnology1477-31552020-04-0118111910.1186/s12951-020-00613-6Application of magnetic nanoparticles in nucleic acid detectionCongli Tang0Ziyu He1Hongmei Liu2Yuyue Xu3Hao Huang4Gaojian Yang5Ziqi Xiao6Song Li7Hongna Liu8Yan Deng9Zhu Chen10Hui Chen11Nongyue He12Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyState Key Laboratory of Bioelectronics, Southeast UniversityAbstract Nucleic acid is the main material for storing, copying, and transmitting genetic information. Gene sequencing is of great significance in DNA damage research, gene therapy, mutation analysis, bacterial infection, drug development, and clinical diagnosis. Gene detection has a wide range of applications, such as environmental, biomedical, pharmaceutical, agriculture and forensic medicine to name a few. Compared with Sanger sequencing, high-throughput sequencing technology has the advantages of larger output, high resolution, and low cost which greatly promotes the application of sequencing technology in life science research. Magnetic nanoparticles, as an important part of nanomaterials, have been widely used in various applications because of their good dispersion, high surface area, low cost, easy separation in buffer systems and signal detection. Based on the above, the application of magnetic nanoparticles in nucleic acid detection was reviewed.http://link.springer.com/article/10.1186/s12951-020-00613-6Magnetic nanoparticlesNucleic acid detectionHigh-throughput sequencingClinical diagnosisMagnetic separation |
| spellingShingle | Congli Tang Ziyu He Hongmei Liu Yuyue Xu Hao Huang Gaojian Yang Ziqi Xiao Song Li Hongna Liu Yan Deng Zhu Chen Hui Chen Nongyue He Application of magnetic nanoparticles in nucleic acid detection Journal of Nanobiotechnology Magnetic nanoparticles Nucleic acid detection High-throughput sequencing Clinical diagnosis Magnetic separation |
| title | Application of magnetic nanoparticles in nucleic acid detection |
| title_full | Application of magnetic nanoparticles in nucleic acid detection |
| title_fullStr | Application of magnetic nanoparticles in nucleic acid detection |
| title_full_unstemmed | Application of magnetic nanoparticles in nucleic acid detection |
| title_short | Application of magnetic nanoparticles in nucleic acid detection |
| title_sort | application of magnetic nanoparticles in nucleic acid detection |
| topic | Magnetic nanoparticles Nucleic acid detection High-throughput sequencing Clinical diagnosis Magnetic separation |
| url | http://link.springer.com/article/10.1186/s12951-020-00613-6 |
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