Longitudinal Changes in Functional Connectivity of the Caudate Is Associated With Recovery From Bell’s Palsy
Several studies have demonstrated through resting-state functional magnetic resonance imaging (fMRI) that functional connectivity changes are important in the recovery from Bell’s palsy (BP); however, these studies have only focused on the cortico-cortical connectivity. It is unclear how corticostri...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2019.00295/full |
| _version_ | 1828326937954615296 |
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| author | Sheng Hu Hongxing Kan Junling Kan Chuanfu Li Aihong Yuan ChunSheng Xu Anqin Wang Yi Wang Xuan Bao Tongping Shen Hongli Wu |
| author_facet | Sheng Hu Hongxing Kan Junling Kan Chuanfu Li Aihong Yuan ChunSheng Xu Anqin Wang Yi Wang Xuan Bao Tongping Shen Hongli Wu |
| author_sort | Sheng Hu |
| collection | DOAJ |
| description | Several studies have demonstrated through resting-state functional magnetic resonance imaging (fMRI) that functional connectivity changes are important in the recovery from Bell’s palsy (BP); however, these studies have only focused on the cortico-cortical connectivity. It is unclear how corticostriatal connectivity relates to the recovery process of patients with BP. In the present study, we evaluated the relationship between longitudinal changes of caudate-based functional connectivity and longitudinal changes of facial performance in patients with intractable BP. Twenty-one patients with intractable BP underwent resting-state fMRI as well as facial behavioral assessments prior to treatment (PT) and at the middle stage of treatment (MT); and 21 age- and sex-matched healthy controls (HC) were recruited and received the same protocol. The caudate was divided into dorsal and ventral sub-regions and separate functional connectivity was calculated. Compared with HC, patients with intractable BP at the PT stage showed decreased functional connectivity of both the dorsal and ventral caudate mainly distributed in the somatosensory network, including the bilateral precentral gyrus (MI), left postcentral gyrus, media frontal gyrus, and superior temporal gyrus (STG). Alternatively, patients in the MT stage showed decreased functional connectivity primarily distributed in the executive network and somatosensory network, including the bilateral cingulate cortex (CC), left anterior cingulate cortex (LACC), inferior prefrontal gyrus (IFG), MI, STG, and paracentral lobe. The longitudinal changes in functional connectivity of both the dorsal and ventral caudate were mainly observed in the executive network, including the right ACC, left CC, and IFG. Functional connectivity changes in the right ACC and left IFG were significantly correlated with changes in facial behavioral performance. These findings indicated that corticostriatal connectivity changes are associated with recovery from BP. |
| first_indexed | 2024-04-13T19:47:28Z |
| format | Article |
| id | doaj.art-b091cd0ba9ed4c1cb8c111b5f001b629 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T19:47:28Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-b091cd0ba9ed4c1cb8c111b5f001b6292022-12-22T02:32:40ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652019-11-011110.3389/fnagi.2019.00295478019Longitudinal Changes in Functional Connectivity of the Caudate Is Associated With Recovery From Bell’s PalsySheng Hu0Hongxing Kan1Junling Kan2Chuanfu Li3Aihong Yuan4ChunSheng Xu5Anqin Wang6Yi Wang7Xuan Bao8Tongping Shen9Hongli Wu10Department of Medical Information Engineering, Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Medical Information Engineering, Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Medical Information Engineering, Anhui University of Chinese Medicine, Hefei, ChinaThe First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaThe First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaThe First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaThe First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Medical Information Engineering, Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Medical Information Engineering, Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Medical Information Engineering, Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Medical Information Engineering, Anhui University of Chinese Medicine, Hefei, ChinaSeveral studies have demonstrated through resting-state functional magnetic resonance imaging (fMRI) that functional connectivity changes are important in the recovery from Bell’s palsy (BP); however, these studies have only focused on the cortico-cortical connectivity. It is unclear how corticostriatal connectivity relates to the recovery process of patients with BP. In the present study, we evaluated the relationship between longitudinal changes of caudate-based functional connectivity and longitudinal changes of facial performance in patients with intractable BP. Twenty-one patients with intractable BP underwent resting-state fMRI as well as facial behavioral assessments prior to treatment (PT) and at the middle stage of treatment (MT); and 21 age- and sex-matched healthy controls (HC) were recruited and received the same protocol. The caudate was divided into dorsal and ventral sub-regions and separate functional connectivity was calculated. Compared with HC, patients with intractable BP at the PT stage showed decreased functional connectivity of both the dorsal and ventral caudate mainly distributed in the somatosensory network, including the bilateral precentral gyrus (MI), left postcentral gyrus, media frontal gyrus, and superior temporal gyrus (STG). Alternatively, patients in the MT stage showed decreased functional connectivity primarily distributed in the executive network and somatosensory network, including the bilateral cingulate cortex (CC), left anterior cingulate cortex (LACC), inferior prefrontal gyrus (IFG), MI, STG, and paracentral lobe. The longitudinal changes in functional connectivity of both the dorsal and ventral caudate were mainly observed in the executive network, including the right ACC, left CC, and IFG. Functional connectivity changes in the right ACC and left IFG were significantly correlated with changes in facial behavioral performance. These findings indicated that corticostriatal connectivity changes are associated with recovery from BP.https://www.frontiersin.org/article/10.3389/fnagi.2019.00295/fullBell’s palsycaudatelongitudinal changesfunctional connectivityfunctional magnetic resonance imaging |
| spellingShingle | Sheng Hu Hongxing Kan Junling Kan Chuanfu Li Aihong Yuan ChunSheng Xu Anqin Wang Yi Wang Xuan Bao Tongping Shen Hongli Wu Longitudinal Changes in Functional Connectivity of the Caudate Is Associated With Recovery From Bell’s Palsy Frontiers in Aging Neuroscience Bell’s palsy caudate longitudinal changes functional connectivity functional magnetic resonance imaging |
| title | Longitudinal Changes in Functional Connectivity of the Caudate Is Associated With Recovery From Bell’s Palsy |
| title_full | Longitudinal Changes in Functional Connectivity of the Caudate Is Associated With Recovery From Bell’s Palsy |
| title_fullStr | Longitudinal Changes in Functional Connectivity of the Caudate Is Associated With Recovery From Bell’s Palsy |
| title_full_unstemmed | Longitudinal Changes in Functional Connectivity of the Caudate Is Associated With Recovery From Bell’s Palsy |
| title_short | Longitudinal Changes in Functional Connectivity of the Caudate Is Associated With Recovery From Bell’s Palsy |
| title_sort | longitudinal changes in functional connectivity of the caudate is associated with recovery from bell s palsy |
| topic | Bell’s palsy caudate longitudinal changes functional connectivity functional magnetic resonance imaging |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2019.00295/full |
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