The diagnostic and prognostic potential of gut bacteria in inflammatory bowel disease
ABSTRACTThe gut microbiome serves as a signaling hub that integrates environmental inputs with genetic and immune signals to influence the host’s metabolism and immunity. Gut bacteria are intricately connected with human health and disease state, with specific bacteria species driving the characteri...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2176118 |
| _version_ | 1797236674639429632 |
|---|---|
| author | Dickson Kofi Wiredu Ocansey Sanhua Hang Xinyi Yuan Hua Qian Mengjiao Zhou Chinasa Valerie Olovo Xu Zhang Fei Mao |
| author_facet | Dickson Kofi Wiredu Ocansey Sanhua Hang Xinyi Yuan Hua Qian Mengjiao Zhou Chinasa Valerie Olovo Xu Zhang Fei Mao |
| author_sort | Dickson Kofi Wiredu Ocansey |
| collection | DOAJ |
| description | ABSTRACTThe gut microbiome serves as a signaling hub that integrates environmental inputs with genetic and immune signals to influence the host’s metabolism and immunity. Gut bacteria are intricately connected with human health and disease state, with specific bacteria species driving the characteristic dysbiosis found in gastrointestinal conditions such as inflammatory bowel disease (IBD); thus, gut bacteria changes could be harnessed to improve IBD diagnosis, prognosis, and treatment. The advancement in next-generation sequencing techniques such as 16S rRNA and whole-genome shotgun sequencing has allowed the exploration of the complexity of the gut microbial ecosystem with high resolution. Current microbiome data is promising and appears to perform better in some studies than the currently used fecal inflammation biomarker, calprotectin, in predicting IBD from healthy controls and irritable bowel syndrome (IBS). This study reviews current data on the differential potential of gut bacteria within IBD cohorts, and between IBD and other gastrointestinal diseases. |
| first_indexed | 2024-03-11T14:20:39Z |
| format | Article |
| id | doaj.art-b093cefe8c9647c7b786fb0b723798b8 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:07:37Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-b093cefe8c9647c7b786fb0b723798b82024-03-28T22:38:19ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2176118The diagnostic and prognostic potential of gut bacteria in inflammatory bowel diseaseDickson Kofi Wiredu Ocansey0Sanhua Hang1Xinyi Yuan2Hua Qian3Mengjiao Zhou4Chinasa Valerie Olovo5Xu Zhang6Fei Mao7Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, P.R. ChinaThe People’s Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Zhenjiang, P.R. ChinaKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, P.R. ChinaAffiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, P.R. ChinaKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, P.R. ChinaKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, P.R. ChinaKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, P.R. ChinaKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, P.R. ChinaABSTRACTThe gut microbiome serves as a signaling hub that integrates environmental inputs with genetic and immune signals to influence the host’s metabolism and immunity. Gut bacteria are intricately connected with human health and disease state, with specific bacteria species driving the characteristic dysbiosis found in gastrointestinal conditions such as inflammatory bowel disease (IBD); thus, gut bacteria changes could be harnessed to improve IBD diagnosis, prognosis, and treatment. The advancement in next-generation sequencing techniques such as 16S rRNA and whole-genome shotgun sequencing has allowed the exploration of the complexity of the gut microbial ecosystem with high resolution. Current microbiome data is promising and appears to perform better in some studies than the currently used fecal inflammation biomarker, calprotectin, in predicting IBD from healthy controls and irritable bowel syndrome (IBS). This study reviews current data on the differential potential of gut bacteria within IBD cohorts, and between IBD and other gastrointestinal diseases.https://www.tandfonline.com/doi/10.1080/19490976.2023.2176118Gut bacteriadiagnosisprognosisinflammatory bowel diseasegastrointestinal diseasemicrobiota |
| spellingShingle | Dickson Kofi Wiredu Ocansey Sanhua Hang Xinyi Yuan Hua Qian Mengjiao Zhou Chinasa Valerie Olovo Xu Zhang Fei Mao The diagnostic and prognostic potential of gut bacteria in inflammatory bowel disease Gut Microbes Gut bacteria diagnosis prognosis inflammatory bowel disease gastrointestinal disease microbiota |
| title | The diagnostic and prognostic potential of gut bacteria in inflammatory bowel disease |
| title_full | The diagnostic and prognostic potential of gut bacteria in inflammatory bowel disease |
| title_fullStr | The diagnostic and prognostic potential of gut bacteria in inflammatory bowel disease |
| title_full_unstemmed | The diagnostic and prognostic potential of gut bacteria in inflammatory bowel disease |
| title_short | The diagnostic and prognostic potential of gut bacteria in inflammatory bowel disease |
| title_sort | diagnostic and prognostic potential of gut bacteria in inflammatory bowel disease |
| topic | Gut bacteria diagnosis prognosis inflammatory bowel disease gastrointestinal disease microbiota |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2176118 |
| work_keys_str_mv | AT dicksonkofiwireduocansey thediagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT sanhuahang thediagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT xinyiyuan thediagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT huaqian thediagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT mengjiaozhou thediagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT chinasavalerieolovo thediagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT xuzhang thediagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT feimao thediagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT dicksonkofiwireduocansey diagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT sanhuahang diagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT xinyiyuan diagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT huaqian diagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT mengjiaozhou diagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT chinasavalerieolovo diagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT xuzhang diagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease AT feimao diagnosticandprognosticpotentialofgutbacteriaininflammatoryboweldisease |