Racial differences in quantitative optical coherence tomography angiography findings between older non-diabetics with co-morbidities.
This cross-sectional study compared optical coherence tomography angiography (OCTA) parameters between older Black and White adults with systemic comorbidities in an effort to further understand racial differences in the retinal microvasculature. We analyzed vessel density at the superficial (SCP),...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0285360 |
| _version_ | 1797805713367498752 |
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| author | John Moir Sarah H Rodriguez Lindsay Y Chun Nathalie Massamba Dimitra Skondra |
| author_facet | John Moir Sarah H Rodriguez Lindsay Y Chun Nathalie Massamba Dimitra Skondra |
| author_sort | John Moir |
| collection | DOAJ |
| description | This cross-sectional study compared optical coherence tomography angiography (OCTA) parameters between older Black and White adults with systemic comorbidities in an effort to further understand racial differences in the retinal microvasculature. We analyzed vessel density at the superficial (SCP), intermediate (ICP), and deep capillary plexuses (DCP), foveal avascular zone (FAZ) parameters, and blood flow area (BFA) at the choriocapillaris. We used a mixed-effects linear regression model, controlling for hypertension and two eyes from the same subject, to compare OCTA parameters. Black subjects had lower foveal vessel density at the SCP and ICP, while no differences were observed at the parafovea or 3x3 mm macular area of any capillary layer. Black subjects had greater FAZ area, perimeter, and FD-300, a measurement of vessel density in a 300 μm wide ring around the FAZ. Black subjects also had lower BFA at the choriocapillaris. Within a cohort of subjects without hypertension, these differences remained statistically significant, with the exception of foveal vessel density at the SCP and foveal BFA of the choriocapillaris. These findings suggest that normative databases of OCTA parameters must strive to be diverse in nature to adequately capture differences across patient populations. Further study is required to understand if baseline differences in OCTA parameters contribute to epidemiological disparities in ocular diseases. |
| first_indexed | 2024-03-13T05:56:13Z |
| format | Article |
| id | doaj.art-b0967dbc72f54a4f9c5f93cfee721b04 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-13T05:56:13Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-b0967dbc72f54a4f9c5f93cfee721b042023-06-13T05:31:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01185e028536010.1371/journal.pone.0285360Racial differences in quantitative optical coherence tomography angiography findings between older non-diabetics with co-morbidities.John MoirSarah H RodriguezLindsay Y ChunNathalie MassambaDimitra SkondraThis cross-sectional study compared optical coherence tomography angiography (OCTA) parameters between older Black and White adults with systemic comorbidities in an effort to further understand racial differences in the retinal microvasculature. We analyzed vessel density at the superficial (SCP), intermediate (ICP), and deep capillary plexuses (DCP), foveal avascular zone (FAZ) parameters, and blood flow area (BFA) at the choriocapillaris. We used a mixed-effects linear regression model, controlling for hypertension and two eyes from the same subject, to compare OCTA parameters. Black subjects had lower foveal vessel density at the SCP and ICP, while no differences were observed at the parafovea or 3x3 mm macular area of any capillary layer. Black subjects had greater FAZ area, perimeter, and FD-300, a measurement of vessel density in a 300 μm wide ring around the FAZ. Black subjects also had lower BFA at the choriocapillaris. Within a cohort of subjects without hypertension, these differences remained statistically significant, with the exception of foveal vessel density at the SCP and foveal BFA of the choriocapillaris. These findings suggest that normative databases of OCTA parameters must strive to be diverse in nature to adequately capture differences across patient populations. Further study is required to understand if baseline differences in OCTA parameters contribute to epidemiological disparities in ocular diseases.https://doi.org/10.1371/journal.pone.0285360 |
| spellingShingle | John Moir Sarah H Rodriguez Lindsay Y Chun Nathalie Massamba Dimitra Skondra Racial differences in quantitative optical coherence tomography angiography findings between older non-diabetics with co-morbidities. PLoS ONE |
| title | Racial differences in quantitative optical coherence tomography angiography findings between older non-diabetics with co-morbidities. |
| title_full | Racial differences in quantitative optical coherence tomography angiography findings between older non-diabetics with co-morbidities. |
| title_fullStr | Racial differences in quantitative optical coherence tomography angiography findings between older non-diabetics with co-morbidities. |
| title_full_unstemmed | Racial differences in quantitative optical coherence tomography angiography findings between older non-diabetics with co-morbidities. |
| title_short | Racial differences in quantitative optical coherence tomography angiography findings between older non-diabetics with co-morbidities. |
| title_sort | racial differences in quantitative optical coherence tomography angiography findings between older non diabetics with co morbidities |
| url | https://doi.org/10.1371/journal.pone.0285360 |
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