An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects.

An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects.

Acetyl coenzyme A carboxylase B gene (ACACB) single nucleotide polymorphism (SNP) rs2268388 is reproducibly associated with type 2 diabetes (T2DM)-associated nephropathy (DN). ACACB knock-out mice are also protected from obesity. This study assessed relationships between rs2268388, body mass index (...

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Bibliographic Details
Main Authors: Lijun Ma, Mariana Murea, James A Snipes, Alejandra Marinelarena, Jacqueline Krüger, Pamela J Hicks, Kurt A Langberg, Meredith A Bostrom, Jessica N Cooke, Daisuke Suzuki, Tetsuya Babazono, Takashi Uzu, Sydney C W Tang, Ashis K Mondal, Neeraj K Sharma, Sayuko Kobes, Peter A Antinozzi, Matthew Davis, Swapan K Das, Neda Rasouli, Philip A Kern, Nathan J Shores, Lawrence L Rudel, Matthias Blüher, Michael Stumvoll, Donald W Bowden, Shiro Maeda, John S Parks, Peter Kovacs, Robert L Hanson, Leslie J Baier, Steven C Elbein, Barry I Freedman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3584087?pdf=render

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