A Spanish Neuropsychological Battery Discriminates Between the Behavioral Variant of Frontotemporal Dementia and Primary Progressive Aphasia in a Colombian Sample
The differential diagnosis among the behavioral variant of frontotemporal dementia FTD (bvFTD) and the linguist one primary progressive aphasia (PPA) is challenging. Presentations of dementia type or variants dominated by personality change or aphasia are frequently misinterpreted as psychiatric ill...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.656478/full |
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| author | Lina Velilla Jonathan Hernández Margarita Giraldo-Chica Edmarie Guzmán-Vélez Yakeel Quiroz Yakeel Quiroz Francisco Lopera |
| author_facet | Lina Velilla Jonathan Hernández Margarita Giraldo-Chica Edmarie Guzmán-Vélez Yakeel Quiroz Yakeel Quiroz Francisco Lopera |
| author_sort | Lina Velilla |
| collection | DOAJ |
| description | The differential diagnosis among the behavioral variant of frontotemporal dementia FTD (bvFTD) and the linguist one primary progressive aphasia (PPA) is challenging. Presentations of dementia type or variants dominated by personality change or aphasia are frequently misinterpreted as psychiatric illness, stroke, or other conditions. Therefore, it is important to identify cognitive tests that can distinguish the distinct FTD variants to reduce misdiagnosis and best tailor interventions. We aim to examine the discriminative capacity of the most frequently used cognitive tests in their Spanish version for the context of dementia evaluation as well as the qualitative aspects of the neuropsychological performance such as the frequency and type of errors, perseverations, and false positives that can best discriminate between bvFTD and PPA. We also described mood and behavioral profiles of participants with mild to moderate probable bvFTD and PPA. A total of 55 subjects were included in this cross-sectional study: 20 with PPA and 35 with bvFTD. All participants underwent standard dementia screening that included a medical history and physical examination, brain MRI, a semistructured caregiver interview, and neuropsychological testing. We found that bvFTD patients had worse performance in executive function tests, and the PPA presented with the lower performance in language tests and the global score of Mini-Mental State Examination (MMSE). After running the linear discriminant model, we found three functions of cognitive test and subtests combination and three functions made by the Montreal Cognitive Assessment (MoCA) language subtest and performance errors that predicted group belonging. Those functions were more capable to classify bvFTD cases rather than PPA. In conclusion, our study supports that the combination of an individual test of executive function and language, MoCA's subtest, and performance errors as well have good accuracy to discriminate between bvFTD and PPA. |
| first_indexed | 2024-12-16T09:40:54Z |
| format | Article |
| id | doaj.art-b099449054094bfda2f676c195c659cf |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-16T09:40:54Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-b099449054094bfda2f676c195c659cf2022-12-21T22:36:17ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-07-011210.3389/fneur.2021.656478656478A Spanish Neuropsychological Battery Discriminates Between the Behavioral Variant of Frontotemporal Dementia and Primary Progressive Aphasia in a Colombian SampleLina Velilla0Jonathan Hernández1Margarita Giraldo-Chica2Edmarie Guzmán-Vélez3Yakeel Quiroz4Yakeel Quiroz5Francisco Lopera6Neuroscience Group of Antioquia, The University of Antioquia, Medellín, ColombiaPsychology Department, University Institution of Envigado, Envigado, ColombiaNeuroscience Group of Antioquia, The University of Antioquia, Medellín, ColombiaHarvard Medical School, Massachusetts General Hospital, Boston, MA, United StatesNeuroscience Group of Antioquia, The University of Antioquia, Medellín, ColombiaHarvard Medical School, Massachusetts General Hospital, Boston, MA, United StatesNeuroscience Group of Antioquia, The University of Antioquia, Medellín, ColombiaThe differential diagnosis among the behavioral variant of frontotemporal dementia FTD (bvFTD) and the linguist one primary progressive aphasia (PPA) is challenging. Presentations of dementia type or variants dominated by personality change or aphasia are frequently misinterpreted as psychiatric illness, stroke, or other conditions. Therefore, it is important to identify cognitive tests that can distinguish the distinct FTD variants to reduce misdiagnosis and best tailor interventions. We aim to examine the discriminative capacity of the most frequently used cognitive tests in their Spanish version for the context of dementia evaluation as well as the qualitative aspects of the neuropsychological performance such as the frequency and type of errors, perseverations, and false positives that can best discriminate between bvFTD and PPA. We also described mood and behavioral profiles of participants with mild to moderate probable bvFTD and PPA. A total of 55 subjects were included in this cross-sectional study: 20 with PPA and 35 with bvFTD. All participants underwent standard dementia screening that included a medical history and physical examination, brain MRI, a semistructured caregiver interview, and neuropsychological testing. We found that bvFTD patients had worse performance in executive function tests, and the PPA presented with the lower performance in language tests and the global score of Mini-Mental State Examination (MMSE). After running the linear discriminant model, we found three functions of cognitive test and subtests combination and three functions made by the Montreal Cognitive Assessment (MoCA) language subtest and performance errors that predicted group belonging. Those functions were more capable to classify bvFTD cases rather than PPA. In conclusion, our study supports that the combination of an individual test of executive function and language, MoCA's subtest, and performance errors as well have good accuracy to discriminate between bvFTD and PPA.https://www.frontiersin.org/articles/10.3389/fneur.2021.656478/fullfrontotemporal dementiaprimary progressive aphasiabehavioral variantneuropsychological testsdiscriminant analyses |
| spellingShingle | Lina Velilla Jonathan Hernández Margarita Giraldo-Chica Edmarie Guzmán-Vélez Yakeel Quiroz Yakeel Quiroz Francisco Lopera A Spanish Neuropsychological Battery Discriminates Between the Behavioral Variant of Frontotemporal Dementia and Primary Progressive Aphasia in a Colombian Sample Frontiers in Neurology frontotemporal dementia primary progressive aphasia behavioral variant neuropsychological tests discriminant analyses |
| title | A Spanish Neuropsychological Battery Discriminates Between the Behavioral Variant of Frontotemporal Dementia and Primary Progressive Aphasia in a Colombian Sample |
| title_full | A Spanish Neuropsychological Battery Discriminates Between the Behavioral Variant of Frontotemporal Dementia and Primary Progressive Aphasia in a Colombian Sample |
| title_fullStr | A Spanish Neuropsychological Battery Discriminates Between the Behavioral Variant of Frontotemporal Dementia and Primary Progressive Aphasia in a Colombian Sample |
| title_full_unstemmed | A Spanish Neuropsychological Battery Discriminates Between the Behavioral Variant of Frontotemporal Dementia and Primary Progressive Aphasia in a Colombian Sample |
| title_short | A Spanish Neuropsychological Battery Discriminates Between the Behavioral Variant of Frontotemporal Dementia and Primary Progressive Aphasia in a Colombian Sample |
| title_sort | spanish neuropsychological battery discriminates between the behavioral variant of frontotemporal dementia and primary progressive aphasia in a colombian sample |
| topic | frontotemporal dementia primary progressive aphasia behavioral variant neuropsychological tests discriminant analyses |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.656478/full |
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