An update regarding the role of WNK kinases in cancer
Abstract Mammalian WNK kinases (WNKs) are serine/threonine kinases that contain four members, WNK1–4. They function to maintain ion homeostasis and regulate blood pressure in mammals. Recent studies have revealed that the dysregulation of WNKs contributes to tumor growth, metastasis, and angiogenesi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-09-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-022-05249-y |
| _version_ | 1798001483792252928 |
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| author | Mengxi Xiu Li Li Yandong Li Yong Gao |
| author_facet | Mengxi Xiu Li Li Yandong Li Yong Gao |
| author_sort | Mengxi Xiu |
| collection | DOAJ |
| description | Abstract Mammalian WNK kinases (WNKs) are serine/threonine kinases that contain four members, WNK1–4. They function to maintain ion homeostasis and regulate blood pressure in mammals. Recent studies have revealed that the dysregulation of WNKs contributes to tumor growth, metastasis, and angiogenesis through complex mechanisms, especially through phosphorylating kinase substrates SPS1-related proline/alanine-rich kinase (SPAK) and oxidative stress-responsive kinase 1 (OSR1). Here, we review and discuss the relationships between WNKs and several key factors/biological processes in cancer, including ion channels, cation chloride cotransporters, sodium bicarbonate cotransporters, signaling pathways, angiogenesis, autophagy, and non-coding RNAs. In addition, the potential drugs for targeting WNK-SPAK/OSR1 signaling have also been discussed. This review summarizes and discusses knowledge of the roles of WNKs in cancer, which provides a comprehensive reference for future studies. |
| first_indexed | 2024-04-11T11:38:11Z |
| format | Article |
| id | doaj.art-b099b0b0a379456baae9d9cdeab5c642 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-04-11T11:38:11Z |
| publishDate | 2022-09-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-b099b0b0a379456baae9d9cdeab5c6422022-12-22T04:25:55ZengNature Publishing GroupCell Death and Disease2041-48892022-09-0113911510.1038/s41419-022-05249-yAn update regarding the role of WNK kinases in cancerMengxi Xiu0Li Li1Yandong Li2Yong Gao3Department of Oncology, Shanghai East Hospital, Tongji University School of MedicineDepartment of Oncology, Shanghai East Hospital, Tongji University School of MedicineDepartment of Oncology, Shanghai East Hospital, Tongji University School of MedicineDepartment of Oncology, Shanghai East Hospital, Tongji University School of MedicineAbstract Mammalian WNK kinases (WNKs) are serine/threonine kinases that contain four members, WNK1–4. They function to maintain ion homeostasis and regulate blood pressure in mammals. Recent studies have revealed that the dysregulation of WNKs contributes to tumor growth, metastasis, and angiogenesis through complex mechanisms, especially through phosphorylating kinase substrates SPS1-related proline/alanine-rich kinase (SPAK) and oxidative stress-responsive kinase 1 (OSR1). Here, we review and discuss the relationships between WNKs and several key factors/biological processes in cancer, including ion channels, cation chloride cotransporters, sodium bicarbonate cotransporters, signaling pathways, angiogenesis, autophagy, and non-coding RNAs. In addition, the potential drugs for targeting WNK-SPAK/OSR1 signaling have also been discussed. This review summarizes and discusses knowledge of the roles of WNKs in cancer, which provides a comprehensive reference for future studies.https://doi.org/10.1038/s41419-022-05249-y |
| spellingShingle | Mengxi Xiu Li Li Yandong Li Yong Gao An update regarding the role of WNK kinases in cancer Cell Death and Disease |
| title | An update regarding the role of WNK kinases in cancer |
| title_full | An update regarding the role of WNK kinases in cancer |
| title_fullStr | An update regarding the role of WNK kinases in cancer |
| title_full_unstemmed | An update regarding the role of WNK kinases in cancer |
| title_short | An update regarding the role of WNK kinases in cancer |
| title_sort | update regarding the role of wnk kinases in cancer |
| url | https://doi.org/10.1038/s41419-022-05249-y |
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