Clinical Presentation and Management of a Dinutuximab Beta Extravasation in a Patient with Neuroblastoma

Clinical Presentation and Management of a Dinutuximab Beta Extravasation in a Patient with Neuroblastoma

Extravasation can present serious accidental complication of intravenous drug application. While monoclonal antibodies do not show the necrotic potential of cytotoxic chemotherapy drugs, considerable inflammatory toxicity can occur, necessitating standardized operating procedures for the management...

Full description

Bibliographic Details
Main Authors:	Michael Launspach, Marita Seif, Theresa M. Thole, Patrick Jesse, Joachim Schulz, Johannes H. Schulte, Susan Bischoff, Angelika Eggert, Hedwig E. Deubzer
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Series:	Children
Subjects:	cancer immunotherapy monoclonal antibody soft tissue inflammation
Online Access:	https://www.mdpi.com/2227-9067/8/2/91

Similar Items

Novel drug - dinutuximab for high-risk neuroblastoma
by: Supriya Kushwah, et al.
Published: (2018-01-01)

Nivolumab and dinutuximab beta in two patients with refractory neuroblastoma
by: Holger Lode, et al.
Published: (2020-05-01)

Early Use of Dinutuximab Beta in Patients with High-Risk Neuroblastoma
by: Neofit Spasov, et al.
Published: (2021-01-01)

GD2-directed bispecific trifunctional antibody outperforms dinutuximab beta in a murine model for aggressive metastasized neuroblastoma
by: Annette Künkele, et al.
Published: (2021-07-01)

Dinutuximab Beta in Children with High-Risk Neuroblastoma: Experience from a Single Center in Croatia
by: Jasminka Stepan Giljević, et al.
Published: (2022-06-01)

Rhombencephalitis and longitudinal extensive myelitis associated with dinutuximab use in high-risk neuroblastoma
by: Fırat Atak, et al.
Published: (2023-06-01)

Initiation of immunotherapy with activated natural killer cells and anti-GD2 antibody dinutuximab prior to resection of primary neuroblastoma prolongs survival in mice
by: Jianping Sun, et al.
Published: (2020-10-01)

Pharmacokinetics of doxorubicin following concomitant intravenous administration of olaratumab (IMC‐3G3) to patients with advanced soft tissue sarcoma
by: Victor M. Villalobos, et al.
Published: (2020-02-01)

Ketamine Infusion as an Adjunct to Opioid Analgesia in Pediatric Patients with High-Risk Neuroblastoma Undergoing Treatment with Dinutuximab: Adverse Effects and Safety in a Non-ICU Setting
by: Streby KA, et al.
Published: (2025-01-01)

Large-scale production of monoclonal antibodies in suspension culture /
by: 271860 Backer, M. P., et al.

Soft β-Separation Axioms in Soft Quad Topological Spaces
by: Arif Mehmood Khattak, et al.
Published: (2018-03-01)

Rituximab therapy after pediatric hematopoietic stem cell transplantation can cause prolonged B-cell impairment and increases the risk for infections - a retrospective matched cohort study
by: Michael Launspach, et al.
Published: (2022-09-01)

SOFT IDEALS OVER A SEMIGROUP GENERATED BY A SOFT SET
by: Ahmed Ramadan, et al.
Published: (2017-09-01)

Monoclonal antibodies : the second generation /
by: 186276 Zola, Heddy
Published: (1995)

On fuzzy soft $ \beta $-continuity and $ \beta $-irresoluteness: some new results
by: Ibtesam Alshammari, et al.
Published: (2024-03-01)

Dual-labeled anti-GD2 targeted probe for intraoperative molecular imaging of neuroblastoma
by: Lauren Taylor Rosenblum, et al.
Published: (2024-10-01)

Monoclonal antibodies against Mycobacterium tuberculosis, detecting the antigen in urine of the pulmonary tuberculosis patients
by: A. V. Onyan, et al.
Published: (2016-02-01)

Relative Quantitative RT-PCR Protocol for TrkB Expression in Neuroblastoma Using GAPD as an Internal Control
by: Angelika Eggert, et al.
Published: (2000-04-01)

Process scale purification of antibodies /
by: Gottschalk, Uwe
Published: (2009)

Development of antibody-based therapeutics : translational considerations /
by: Tabrizi, Mohammad A., et al.
Published: (c201)

Current trends in monoclonal antibody development and manufacturing /
by: Shire, Steven J.
Published: (2010)

Monoclonal antibodies : principles and practice : production and application of monoclonal antibodies in cell biology, biochemistry and immunology /
by: 250151 Goding, James W.
Published: (1996)

Monoclonal antibodies /
by: Peter, J. H., et al.
Published: (1992)

In vivo Extravasation Assay
by: Elisa Penna, et al.
Published: (2014-02-01)

Guidelines for the management of extravasation
by: Jung Tae Kim, et al.
Published: (2020-08-01)

Recombinant antibodies for immunotherapy /
by: Little, Melvyn
Published: (2009)

Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity
by: Maja C. Stöber, et al.
Published: (2024-09-01)

Identification and characterisation of candidate monoclonal antibody Ebolavirus therapeutics
by: Donnellan, FR
Published: (2021)

Localization of the antigenic sites of Newcastle disease virus nucleocapsid using a panel of monoclonal antibodies
by: Ahmad-Raus, Raha, et al.
Published: (2009)

The identification and correction of pseudohypercalcemia
by: Tongyong Yu, et al.
Published: (2024-10-01)

Documenting of extravasation of cytotoxic agents
by: Savić Maja, et al.
Published: (2020-01-01)

Investigation of cross-reactive antibodies against Plasmodium falciparum-infected erythrocytes
by: Tan, J
Published: (2016)

The use of continuous culture to enhance monoclonal antibody production /
by: 316412 Macmichael, Gregory J.

Monoclonal antibodies : principles and practice : production and application of monoclonal antibodies in cell biology, biochemistry, and immunology /
by: 250151 Goding, James W.
Published: (1986)

Monoclonal antibodies to Ia glycoproteins from rat thymus and spleen
by: McMaster, W, et al.
Published: (1979)

Monoclonal antibodies : a manual of techniques /
by: 186276 Zola, Heddy
Published: (1987)

Development of monoclonal antibodies against porcine blood for detection in fish-based products
by: Raja Nhari, Raja Mohd Hafidz
Published: (2017)

Monoclonal antibodies : methods and protocols /
by: Albitar, Maher
Published: (2007)

A structured kinetic modeling framework for the dynamics of hybridoma growth and monoclonal antibody production in continuous suspension cultures /
by: 305833 Batt, Brian C., et al.

Monoclonal antibodies in immunoscintigraphy /
by: Chatal, Jean-Francois
Published: (1989)