<i>COL12A1</i> Single Nucleotide Polymorphisms rs240736 and rs970547 Are Not Associated with Temporomandibular Joint Disc Displacement without Reduction
Temporomandibular disorders (TMDs) may affect up to 25% of the population, with almost 70% of these TMD cases developing malpositioning of the disc over time in what is known as internal derangement (ID). Despite significant efforts, the molecular mechanism underlying disease progression is not yet...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/5/690 |
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| author | Bartosz Dalewski Katarzyna Kaczmarek Anna Jakubowska Kamila Szczuchniak Łukasz Pałka Ewa Sobolewska |
| author_facet | Bartosz Dalewski Katarzyna Kaczmarek Anna Jakubowska Kamila Szczuchniak Łukasz Pałka Ewa Sobolewska |
| author_sort | Bartosz Dalewski |
| collection | DOAJ |
| description | Temporomandibular disorders (TMDs) may affect up to 25% of the population, with almost 70% of these TMD cases developing malpositioning of the disc over time in what is known as internal derangement (ID). Despite significant efforts, the molecular mechanism underlying disease progression is not yet very well known. In this study, the role of <i>COL12A1</i> rs970547 and rs240736 polymorphisms as potential genetic factors regulating ID was investigated. The study included 124 Caucasian patients of both sexes after disc displacement without reduction (DDwoR) in either one or two temporomandibular joints (TMJs), either of which meet the criteria for this condition. All patients underwent clinical examination and 3D digital imaging. The <i>COL12A1</i> rs970547 and rs240736 polymorphisms were evaluated. There were no statistically significant differences in the chi-square test between the study group and healthy controls. The examined <i>COL12A1</i> rs240736 and rs970547 polymorphisms do not contribute to DDwoR in Polish Caucasians. |
| first_indexed | 2024-03-10T11:42:38Z |
| format | Article |
| id | doaj.art-b099ea8863c240bebb43f504abe4e8e2 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T11:42:38Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-b099ea8863c240bebb43f504abe4e8e22023-11-21T18:24:26ZengMDPI AGGenes2073-44252021-05-0112569010.3390/genes12050690<i>COL12A1</i> Single Nucleotide Polymorphisms rs240736 and rs970547 Are Not Associated with Temporomandibular Joint Disc Displacement without ReductionBartosz Dalewski0Katarzyna Kaczmarek1Anna Jakubowska2Kamila Szczuchniak3Łukasz Pałka4Ewa Sobolewska5Department of Dental Prosthetics, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Genetics and Pathology, Pomeranian Medical University, 71-252 Szczecin, PolandDepartment of Genetics and Pathology, Pomeranian Medical University, 71-252 Szczecin, PolandDepartment of Dental Prosthetics, Outpatient Dental Clinic, Pomeranian Medical University, 70-111 Szczecin, PolandPrivate Dental Practice, 68-200 Żary, PolandDepartment of Dental Prosthetics, Pomeranian Medical University, 70-111 Szczecin, PolandTemporomandibular disorders (TMDs) may affect up to 25% of the population, with almost 70% of these TMD cases developing malpositioning of the disc over time in what is known as internal derangement (ID). Despite significant efforts, the molecular mechanism underlying disease progression is not yet very well known. In this study, the role of <i>COL12A1</i> rs970547 and rs240736 polymorphisms as potential genetic factors regulating ID was investigated. The study included 124 Caucasian patients of both sexes after disc displacement without reduction (DDwoR) in either one or two temporomandibular joints (TMJs), either of which meet the criteria for this condition. All patients underwent clinical examination and 3D digital imaging. The <i>COL12A1</i> rs970547 and rs240736 polymorphisms were evaluated. There were no statistically significant differences in the chi-square test between the study group and healthy controls. The examined <i>COL12A1</i> rs240736 and rs970547 polymorphisms do not contribute to DDwoR in Polish Caucasians.https://www.mdpi.com/2073-4425/12/5/690TMJDDwoRpolymorphismSNParticular discTMD |
| spellingShingle | Bartosz Dalewski Katarzyna Kaczmarek Anna Jakubowska Kamila Szczuchniak Łukasz Pałka Ewa Sobolewska <i>COL12A1</i> Single Nucleotide Polymorphisms rs240736 and rs970547 Are Not Associated with Temporomandibular Joint Disc Displacement without Reduction Genes TMJ DDwoR polymorphism SNP articular disc TMD |
| title | <i>COL12A1</i> Single Nucleotide Polymorphisms rs240736 and rs970547 Are Not Associated with Temporomandibular Joint Disc Displacement without Reduction |
| title_full | <i>COL12A1</i> Single Nucleotide Polymorphisms rs240736 and rs970547 Are Not Associated with Temporomandibular Joint Disc Displacement without Reduction |
| title_fullStr | <i>COL12A1</i> Single Nucleotide Polymorphisms rs240736 and rs970547 Are Not Associated with Temporomandibular Joint Disc Displacement without Reduction |
| title_full_unstemmed | <i>COL12A1</i> Single Nucleotide Polymorphisms rs240736 and rs970547 Are Not Associated with Temporomandibular Joint Disc Displacement without Reduction |
| title_short | <i>COL12A1</i> Single Nucleotide Polymorphisms rs240736 and rs970547 Are Not Associated with Temporomandibular Joint Disc Displacement without Reduction |
| title_sort | i col12a1 i single nucleotide polymorphisms rs240736 and rs970547 are not associated with temporomandibular joint disc displacement without reduction |
| topic | TMJ DDwoR polymorphism SNP articular disc TMD |
| url | https://www.mdpi.com/2073-4425/12/5/690 |
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