Endovascular revascularisation versus surgical revascularisation in patients with lower limb atherosclerosis obliterans: a protocol for systematic review and meta-analysis with trial sequential analysis and meta-regression
Introduction The revascularisation strategy for lower limb atherosclerosis obliterans (ASO) remains controversial. In this meta-analysis, we will summarise existing evidence to compare the long-term and short-term outcomes between endovascular revascularisation and open revascularisation for patient...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/12/e066903.full |
| _version_ | 1797779138216460288 |
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| author | Peng Qiu Qun Huang Hongxin Shu Chuanfei Zeng Xiaowei Xiong Xinwu Lu |
| author_facet | Peng Qiu Qun Huang Hongxin Shu Chuanfei Zeng Xiaowei Xiong Xinwu Lu |
| author_sort | Peng Qiu |
| collection | DOAJ |
| description | Introduction The revascularisation strategy for lower limb atherosclerosis obliterans (ASO) remains controversial. In this meta-analysis, we will summarise existing evidence to compare the long-term and short-term outcomes between endovascular revascularisation and open revascularisation for patients with ASO.Methods Relevant randomised controlled trials (RCTs) and cohort studies are included from the following databases: MEDLINE/PubMed, Embase and the Cochrane Library. The last search time is 1 August 2022. Two reviewers will independently identify RCTs and cohort studies according to eligibility and exclusion criteria. The risk of bias of included cohort studies, and RCTs are assessed with the Newcastle-Ottawa Scale, Methodological Index of Non-randomized Studies and Cochrane Collaboration’s tool, respectively. The primary outcomes include overall survival, amputation-free survival and 30-day mortality. TSA Beta Software V.0.9.5.10 is used to perform the trial sequential analysis for primary outcomes. The Grades of Recommendations, Assessment, Development and Evaluation (GRADE) tool will be used to assess the level of evidence for outcome from RCTs. Stata V.17.0 software is used to pool primary outcomes.Ethics and dissemination This study will be disseminated through peer-reviewed journals or conference reports. No ethical approval requirements are required because the results presented in this study are conducted based on published data.PROSPERO registration number CRD42022359591 |
| first_indexed | 2024-03-12T23:27:26Z |
| format | Article |
| id | doaj.art-b09a5a9c988845eb88a8584002591bc3 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-12T23:27:26Z |
| publishDate | 2022-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-b09a5a9c988845eb88a8584002591bc32023-07-16T08:00:07ZengBMJ Publishing GroupBMJ Open2044-60552022-12-01121210.1136/bmjopen-2022-066903Endovascular revascularisation versus surgical revascularisation in patients with lower limb atherosclerosis obliterans: a protocol for systematic review and meta-analysis with trial sequential analysis and meta-regressionPeng Qiu0Qun Huang1Hongxin Shu2Chuanfei Zeng3Xiaowei Xiong4Xinwu Lu5Department of Vascular Surgery, Shanghai Ninth People`s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Vascular Surgery, Shanghai Ninth People`s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaThe Second Clinical Medical School, Nanchang University, Nanchang, ChinaDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Vascular Surgery, Nanchang First Hospital, Nanchang, Jiangxi, ChinaDepartment of Vascular Surgery, Shanghai Ninth People`s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaIntroduction The revascularisation strategy for lower limb atherosclerosis obliterans (ASO) remains controversial. In this meta-analysis, we will summarise existing evidence to compare the long-term and short-term outcomes between endovascular revascularisation and open revascularisation for patients with ASO.Methods Relevant randomised controlled trials (RCTs) and cohort studies are included from the following databases: MEDLINE/PubMed, Embase and the Cochrane Library. The last search time is 1 August 2022. Two reviewers will independently identify RCTs and cohort studies according to eligibility and exclusion criteria. The risk of bias of included cohort studies, and RCTs are assessed with the Newcastle-Ottawa Scale, Methodological Index of Non-randomized Studies and Cochrane Collaboration’s tool, respectively. The primary outcomes include overall survival, amputation-free survival and 30-day mortality. TSA Beta Software V.0.9.5.10 is used to perform the trial sequential analysis for primary outcomes. The Grades of Recommendations, Assessment, Development and Evaluation (GRADE) tool will be used to assess the level of evidence for outcome from RCTs. Stata V.17.0 software is used to pool primary outcomes.Ethics and dissemination This study will be disseminated through peer-reviewed journals or conference reports. No ethical approval requirements are required because the results presented in this study are conducted based on published data.PROSPERO registration number CRD42022359591https://bmjopen.bmj.com/content/12/12/e066903.full |
| spellingShingle | Peng Qiu Qun Huang Hongxin Shu Chuanfei Zeng Xiaowei Xiong Xinwu Lu Endovascular revascularisation versus surgical revascularisation in patients with lower limb atherosclerosis obliterans: a protocol for systematic review and meta-analysis with trial sequential analysis and meta-regression BMJ Open |
| title | Endovascular revascularisation versus surgical revascularisation in patients with lower limb atherosclerosis obliterans: a protocol for systematic review and meta-analysis with trial sequential analysis and meta-regression |
| title_full | Endovascular revascularisation versus surgical revascularisation in patients with lower limb atherosclerosis obliterans: a protocol for systematic review and meta-analysis with trial sequential analysis and meta-regression |
| title_fullStr | Endovascular revascularisation versus surgical revascularisation in patients with lower limb atherosclerosis obliterans: a protocol for systematic review and meta-analysis with trial sequential analysis and meta-regression |
| title_full_unstemmed | Endovascular revascularisation versus surgical revascularisation in patients with lower limb atherosclerosis obliterans: a protocol for systematic review and meta-analysis with trial sequential analysis and meta-regression |
| title_short | Endovascular revascularisation versus surgical revascularisation in patients with lower limb atherosclerosis obliterans: a protocol for systematic review and meta-analysis with trial sequential analysis and meta-regression |
| title_sort | endovascular revascularisation versus surgical revascularisation in patients with lower limb atherosclerosis obliterans a protocol for systematic review and meta analysis with trial sequential analysis and meta regression |
| url | https://bmjopen.bmj.com/content/12/12/e066903.full |
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