Salivary Biomarkers: Future Approaches for Early Diagnosis of Neurodegenerative Diseases
Many neurological diseases are characterized by progressive neuronal degeneration. Early diagnosis and new markers are necessary for prompt therapeutic intervention. Several studies have aimed to identify biomarkers in different biological liquids. Furthermore, it is being considered whether saliva...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/4/245 |
| _version_ | 1797570048000262144 |
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| author | Giovanni Schepici Serena Silvestro Oriana Trubiani Placido Bramanti Emanuela Mazzon |
| author_facet | Giovanni Schepici Serena Silvestro Oriana Trubiani Placido Bramanti Emanuela Mazzon |
| author_sort | Giovanni Schepici |
| collection | DOAJ |
| description | Many neurological diseases are characterized by progressive neuronal degeneration. Early diagnosis and new markers are necessary for prompt therapeutic intervention. Several studies have aimed to identify biomarkers in different biological liquids. Furthermore, it is being considered whether saliva could be a potential biological sample for the investigation of neurodegenerative diseases. This work aims to provide an overview of the literature concerning biomarkers identified in saliva for the diagnosis of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Specifically, the studies have revealed that is possible to quantify beta-amyloid<sub>1–42</sub> and TAU protein from the saliva of AD patients. Instead, alpha-synuclein and protein deglycase (DJ-1) have been identified as new potential salivary biomarkers for the diagnosis of PD. Nevertheless, future studies will be needed to validate these salivary biomarkers in the diagnosis of neurological diseases. |
| first_indexed | 2024-03-10T20:20:34Z |
| format | Article |
| id | doaj.art-b09b1457fd974a44b302b2e9f785711f |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T20:20:34Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-b09b1457fd974a44b302b2e9f785711f2023-11-19T22:16:10ZengMDPI AGBrain Sciences2076-34252020-04-0110424510.3390/brainsci10040245Salivary Biomarkers: Future Approaches for Early Diagnosis of Neurodegenerative DiseasesGiovanni Schepici0Serena Silvestro1Oriana Trubiani2Placido Bramanti3Emanuela Mazzon4IRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, ItalyDepartment of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio” Chieti-Pescara, 66100 Chieti, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, ItalyMany neurological diseases are characterized by progressive neuronal degeneration. Early diagnosis and new markers are necessary for prompt therapeutic intervention. Several studies have aimed to identify biomarkers in different biological liquids. Furthermore, it is being considered whether saliva could be a potential biological sample for the investigation of neurodegenerative diseases. This work aims to provide an overview of the literature concerning biomarkers identified in saliva for the diagnosis of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Specifically, the studies have revealed that is possible to quantify beta-amyloid<sub>1–42</sub> and TAU protein from the saliva of AD patients. Instead, alpha-synuclein and protein deglycase (DJ-1) have been identified as new potential salivary biomarkers for the diagnosis of PD. Nevertheless, future studies will be needed to validate these salivary biomarkers in the diagnosis of neurological diseases.https://www.mdpi.com/2076-3425/10/4/245salivary biomarkersAlzheimer’s diseaseParkinson’s diseaseamyotrophic lateral sclerosismultiple sclerosis |
| spellingShingle | Giovanni Schepici Serena Silvestro Oriana Trubiani Placido Bramanti Emanuela Mazzon Salivary Biomarkers: Future Approaches for Early Diagnosis of Neurodegenerative Diseases Brain Sciences salivary biomarkers Alzheimer’s disease Parkinson’s disease amyotrophic lateral sclerosis multiple sclerosis |
| title | Salivary Biomarkers: Future Approaches for Early Diagnosis of Neurodegenerative Diseases |
| title_full | Salivary Biomarkers: Future Approaches for Early Diagnosis of Neurodegenerative Diseases |
| title_fullStr | Salivary Biomarkers: Future Approaches for Early Diagnosis of Neurodegenerative Diseases |
| title_full_unstemmed | Salivary Biomarkers: Future Approaches for Early Diagnosis of Neurodegenerative Diseases |
| title_short | Salivary Biomarkers: Future Approaches for Early Diagnosis of Neurodegenerative Diseases |
| title_sort | salivary biomarkers future approaches for early diagnosis of neurodegenerative diseases |
| topic | salivary biomarkers Alzheimer’s disease Parkinson’s disease amyotrophic lateral sclerosis multiple sclerosis |
| url | https://www.mdpi.com/2076-3425/10/4/245 |
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