Development of an M cell targeted nanocomposite system for effective oral protein delivery: preparation, in vitro and in vivo characterization

Development of an M cell targeted nanocomposite system for effective oral protein delivery: preparation, in vitro and in vivo characterization

Abstract Background There is a strong need for non-invasive and patient-friendly delivery systems of protein drugs for long-term therapy. However, oral delivery of protein drugs is a big challenge due to many barriers including instability in the gastrointestinal (GI) tract and low permeability. To...

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Bibliographic Details
Main Authors: Jae Geun Song, Sang Hoon Lee, Hyo-Kyung Han
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Nanobiotechnology
Subjects:
Insulin
Oral delivery system
M cell targeting
Nano-carrier
Aminoclay
Online Access:https://doi.org/10.1186/s12951-020-00750-y

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