The microRNA and the perspectives of miR-302
MiRNAs are naturally occurring, small, non-coding RNA molecules that post-transcriptionally regulate the expression of a large number of genes involved in various biological processes, either through mRNA degradation or through translation inhibition. MiRNAs play important roles in many aspects of p...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844018370415 |
| _version_ | 1818598086152290304 |
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| author | Emily Yen Yu Chen Jack S. Chen Shao-Yao Ying |
| author_facet | Emily Yen Yu Chen Jack S. Chen Shao-Yao Ying |
| author_sort | Emily Yen Yu Chen |
| collection | DOAJ |
| description | MiRNAs are naturally occurring, small, non-coding RNA molecules that post-transcriptionally regulate the expression of a large number of genes involved in various biological processes, either through mRNA degradation or through translation inhibition. MiRNAs play important roles in many aspects of physiology and pathology throughout the body, particularly in cancer, which have made miRNAs attractive tools and targets for translational research. The types of non-coding RNAs, biogenesis of miRNAs, circulating miRNAs, and direct delivery of miRNA were briefly reviewed. As a case of point, the role and perspective of miR-302, a family of ES-specific miRNA, on cancer, iPSCs, heart disease were presented. |
| first_indexed | 2024-12-16T11:58:06Z |
| format | Article |
| id | doaj.art-b09bc698abe34e85aae38ca22ec54124 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-16T11:58:06Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-b09bc698abe34e85aae38ca22ec541242022-12-21T22:32:31ZengElsevierHeliyon2405-84402019-01-0151e01167The microRNA and the perspectives of miR-302Emily Yen Yu Chen0Jack S. Chen1Shao-Yao Ying2Department of Integrative Anatomical Sciences, Keck School of Medicine, BMT-403, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA; WJWU & LYNN Institute for Stem Cell Research, Santa Fe Springs, CA 90670, USAWJWU & LYNN Institute for Stem Cell Research, Santa Fe Springs, CA 90670, USADepartment of Integrative Anatomical Sciences, Keck School of Medicine, BMT-403, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA; Corresponding author.MiRNAs are naturally occurring, small, non-coding RNA molecules that post-transcriptionally regulate the expression of a large number of genes involved in various biological processes, either through mRNA degradation or through translation inhibition. MiRNAs play important roles in many aspects of physiology and pathology throughout the body, particularly in cancer, which have made miRNAs attractive tools and targets for translational research. The types of non-coding RNAs, biogenesis of miRNAs, circulating miRNAs, and direct delivery of miRNA were briefly reviewed. As a case of point, the role and perspective of miR-302, a family of ES-specific miRNA, on cancer, iPSCs, heart disease were presented.http://www.sciencedirect.com/science/article/pii/S2405844018370415Biomedical engineeringBiochemistryBiotechnologyCancer researchCell biologyDevelopmental biology |
| spellingShingle | Emily Yen Yu Chen Jack S. Chen Shao-Yao Ying The microRNA and the perspectives of miR-302 Heliyon Biomedical engineering Biochemistry Biotechnology Cancer research Cell biology Developmental biology |
| title | The microRNA and the perspectives of miR-302 |
| title_full | The microRNA and the perspectives of miR-302 |
| title_fullStr | The microRNA and the perspectives of miR-302 |
| title_full_unstemmed | The microRNA and the perspectives of miR-302 |
| title_short | The microRNA and the perspectives of miR-302 |
| title_sort | microrna and the perspectives of mir 302 |
| topic | Biomedical engineering Biochemistry Biotechnology Cancer research Cell biology Developmental biology |
| url | http://www.sciencedirect.com/science/article/pii/S2405844018370415 |
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