Predictors of Early Thrombotic Events in Adult Patients with Acute Myeloid Leukemia: A Real-World Experience
Information regarding the incidence and the prognostic impact of thrombotic events (TE) in non-promyelocytic acute myeloid leukemia (AML) is sparse. Although several risk factors associated with an increased risk of TE development have been recognized, we still lack universally approved guidelines f...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/22/5640 |
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| author | Giovangiacinto Paterno Raffaele Palmieri Vittorio Forte Valentina Del Prete Carmelo Gurnari Luca Guarnera Flavia Mallegni Maria Rosaria Pascale Elisa Buzzatti Valeria Mezzanotte Ilaria Cerroni Arianna Savi Francesco Buccisano Luca Maurillo Adriano Venditti Maria Ilaria Del Principe |
| author_facet | Giovangiacinto Paterno Raffaele Palmieri Vittorio Forte Valentina Del Prete Carmelo Gurnari Luca Guarnera Flavia Mallegni Maria Rosaria Pascale Elisa Buzzatti Valeria Mezzanotte Ilaria Cerroni Arianna Savi Francesco Buccisano Luca Maurillo Adriano Venditti Maria Ilaria Del Principe |
| author_sort | Giovangiacinto Paterno |
| collection | DOAJ |
| description | Information regarding the incidence and the prognostic impact of thrombotic events (TE) in non-promyelocytic acute myeloid leukemia (AML) is sparse. Although several risk factors associated with an increased risk of TE development have been recognized, we still lack universally approved guidelines for identification and management of these complications. We retrospectively analyzed 300 consecutive patients with newly diagnosed AML. Reporting the incidence of venous TE (VTE) and arterial TE (ATE) was the primary endpoint. Secondarily, we evaluated baseline patient- and disease-related characteristics with a possible influence of VTE-occurrence probability. Finally, we evaluated the impact of TE on survival. Overall, the VTE incidence was 12.3% and ATE incidence was 2.3%. We identified three independent predictors associated with early-VTE: comorbidities (<i>p</i> = 0.006), platelets count >50 × 10<sup>9</sup>/L (<i>p</i> = 0.006), and a previous history of VTE (<i>p</i> = 0.003). Assigning 1 point to each variable, we observed an overall cumulative incidence of VTE of 18.4% in the high-risk group (≥2 points) versus 6.4% in the low-risk group (0–1 point), log-rank = 0.002. Overall, ATE, but not VTE, was associated with poor prognosis (<i>p</i> < 0.001). In conclusion, TE incidence in AML patients is not negligible. We proposed an early-VTE risk score that could be useful for a proper management of VTE prophylaxis. |
| first_indexed | 2024-03-09T18:26:39Z |
| format | Article |
| id | doaj.art-b09bfc29a8054d518004d2dc78962f83 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T18:26:39Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b09bfc29a8054d518004d2dc78962f832023-11-24T07:54:22ZengMDPI AGCancers2072-66942022-11-011422564010.3390/cancers14225640Predictors of Early Thrombotic Events in Adult Patients with Acute Myeloid Leukemia: A Real-World ExperienceGiovangiacinto Paterno0Raffaele Palmieri1Vittorio Forte2Valentina Del Prete3Carmelo Gurnari4Luca Guarnera5Flavia Mallegni6Maria Rosaria Pascale7Elisa Buzzatti8Valeria Mezzanotte9Ilaria Cerroni10Arianna Savi11Francesco Buccisano12Luca Maurillo13Adriano Venditti14Maria Ilaria Del Principe15Hematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, ItalyInformation regarding the incidence and the prognostic impact of thrombotic events (TE) in non-promyelocytic acute myeloid leukemia (AML) is sparse. Although several risk factors associated with an increased risk of TE development have been recognized, we still lack universally approved guidelines for identification and management of these complications. We retrospectively analyzed 300 consecutive patients with newly diagnosed AML. Reporting the incidence of venous TE (VTE) and arterial TE (ATE) was the primary endpoint. Secondarily, we evaluated baseline patient- and disease-related characteristics with a possible influence of VTE-occurrence probability. Finally, we evaluated the impact of TE on survival. Overall, the VTE incidence was 12.3% and ATE incidence was 2.3%. We identified three independent predictors associated with early-VTE: comorbidities (<i>p</i> = 0.006), platelets count >50 × 10<sup>9</sup>/L (<i>p</i> = 0.006), and a previous history of VTE (<i>p</i> = 0.003). Assigning 1 point to each variable, we observed an overall cumulative incidence of VTE of 18.4% in the high-risk group (≥2 points) versus 6.4% in the low-risk group (0–1 point), log-rank = 0.002. Overall, ATE, but not VTE, was associated with poor prognosis (<i>p</i> < 0.001). In conclusion, TE incidence in AML patients is not negligible. We proposed an early-VTE risk score that could be useful for a proper management of VTE prophylaxis.https://www.mdpi.com/2072-6694/14/22/5640acute myeloid leukemiathrombosisvenous thromboembolismthrombosis risk scoresurvival |
| spellingShingle | Giovangiacinto Paterno Raffaele Palmieri Vittorio Forte Valentina Del Prete Carmelo Gurnari Luca Guarnera Flavia Mallegni Maria Rosaria Pascale Elisa Buzzatti Valeria Mezzanotte Ilaria Cerroni Arianna Savi Francesco Buccisano Luca Maurillo Adriano Venditti Maria Ilaria Del Principe Predictors of Early Thrombotic Events in Adult Patients with Acute Myeloid Leukemia: A Real-World Experience Cancers acute myeloid leukemia thrombosis venous thromboembolism thrombosis risk score survival |
| title | Predictors of Early Thrombotic Events in Adult Patients with Acute Myeloid Leukemia: A Real-World Experience |
| title_full | Predictors of Early Thrombotic Events in Adult Patients with Acute Myeloid Leukemia: A Real-World Experience |
| title_fullStr | Predictors of Early Thrombotic Events in Adult Patients with Acute Myeloid Leukemia: A Real-World Experience |
| title_full_unstemmed | Predictors of Early Thrombotic Events in Adult Patients with Acute Myeloid Leukemia: A Real-World Experience |
| title_short | Predictors of Early Thrombotic Events in Adult Patients with Acute Myeloid Leukemia: A Real-World Experience |
| title_sort | predictors of early thrombotic events in adult patients with acute myeloid leukemia a real world experience |
| topic | acute myeloid leukemia thrombosis venous thromboembolism thrombosis risk score survival |
| url | https://www.mdpi.com/2072-6694/14/22/5640 |
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