Inherited bradyarrhythmia: A diverse genetic background
Bradyarrhythmia is a common heart rhythm abnormality comprising number of diseases and is associated with decreased heart rate due to the failure of action potential generation and propagation at the sinus node. Permanent pacemaker implantation is often used therapeutically to compensate for decreas...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-10-01
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| Series: | Journal of Arrhythmia |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1880427615001350 |
| _version_ | 1818139933807738880 |
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| author | Taisuke Ishikawa, DVM, PhD Yukiomi Tsuji, MD, PhD Naomasa Makita, MD, PhD |
| author_facet | Taisuke Ishikawa, DVM, PhD Yukiomi Tsuji, MD, PhD Naomasa Makita, MD, PhD |
| author_sort | Taisuke Ishikawa, DVM, PhD |
| collection | DOAJ |
| description | Bradyarrhythmia is a common heart rhythm abnormality comprising number of diseases and is associated with decreased heart rate due to the failure of action potential generation and propagation at the sinus node. Permanent pacemaker implantation is often used therapeutically to compensate for decreased heart rate and cardiac output. The vast majority of bradyarrhythmia cases are attributable either to aging or to structural abnormalities of the cardiac conduction system, caused by underlying structural heart disease. However, there is a subset of bradyarrhythmia primarily caused by genetic defects in the absence of aging or underlying structural heart disease. These include several genes that play principal roles in cardiac electrophysiology, heart development, cardioprotection, and the structural integrity of the membrane and sarcomere. Recent advances in the functional analysis of mutations using a heterologous expression system and genetically engineered animal models have provided significant insights into the underlying molecular mechanisms responsible for inherited arrhythmia. In this review, current understandings of the genetic and molecular basis of inherited bradyarrhythmia are presented. |
| first_indexed | 2024-12-11T10:35:58Z |
| format | Article |
| id | doaj.art-b09c4cbadea9492cb0cbf1344fcfdcca |
| institution | Directory Open Access Journal |
| issn | 1880-4276 |
| language | English |
| last_indexed | 2024-12-11T10:35:58Z |
| publishDate | 2016-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Arrhythmia |
| spelling | doaj.art-b09c4cbadea9492cb0cbf1344fcfdcca2022-12-22T01:10:42ZengWileyJournal of Arrhythmia1880-42762016-10-0132535235810.1016/j.joa.2015.09.009Inherited bradyarrhythmia: A diverse genetic backgroundTaisuke Ishikawa, DVM, PhDYukiomi Tsuji, MD, PhDNaomasa Makita, MD, PhDBradyarrhythmia is a common heart rhythm abnormality comprising number of diseases and is associated with decreased heart rate due to the failure of action potential generation and propagation at the sinus node. Permanent pacemaker implantation is often used therapeutically to compensate for decreased heart rate and cardiac output. The vast majority of bradyarrhythmia cases are attributable either to aging or to structural abnormalities of the cardiac conduction system, caused by underlying structural heart disease. However, there is a subset of bradyarrhythmia primarily caused by genetic defects in the absence of aging or underlying structural heart disease. These include several genes that play principal roles in cardiac electrophysiology, heart development, cardioprotection, and the structural integrity of the membrane and sarcomere. Recent advances in the functional analysis of mutations using a heterologous expression system and genetically engineered animal models have provided significant insights into the underlying molecular mechanisms responsible for inherited arrhythmia. In this review, current understandings of the genetic and molecular basis of inherited bradyarrhythmia are presented.http://www.sciencedirect.com/science/article/pii/S1880427615001350BradyarrhythmiaGenome-wide association studiesIon channelSinus nodeCardiac conduction system |
| spellingShingle | Taisuke Ishikawa, DVM, PhD Yukiomi Tsuji, MD, PhD Naomasa Makita, MD, PhD Inherited bradyarrhythmia: A diverse genetic background Journal of Arrhythmia Bradyarrhythmia Genome-wide association studies Ion channel Sinus node Cardiac conduction system |
| title | Inherited bradyarrhythmia: A diverse genetic background |
| title_full | Inherited bradyarrhythmia: A diverse genetic background |
| title_fullStr | Inherited bradyarrhythmia: A diverse genetic background |
| title_full_unstemmed | Inherited bradyarrhythmia: A diverse genetic background |
| title_short | Inherited bradyarrhythmia: A diverse genetic background |
| title_sort | inherited bradyarrhythmia a diverse genetic background |
| topic | Bradyarrhythmia Genome-wide association studies Ion channel Sinus node Cardiac conduction system |
| url | http://www.sciencedirect.com/science/article/pii/S1880427615001350 |
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